Free Radical Biology and Medicine:天然食品添加剂胭脂树橙可预防皮肤癌

2016-02-01 Mechront 译 MedSci原创

亚利桑那大学药学院的研究人员发现,天然食品添加剂中的一种化合物——胭脂树橙,可以防止小鼠癌细胞的形成和紫外线对皮肤的损伤。胭脂树橙是橙红色化合物,主要存在于红木、天然调味品和食品着色的胭脂树果实的种子;是拉丁美洲烹饪的常见成分。wondrak博士的实验室致力于找到食物中可以预防皮肤癌的小分子。张博士Nrf2转录因子领域的专家,该基因可以加强细胞对抗致癌物。wondrak博士偶尔间发现了胭脂树橙可以

亚利桑那大学药学院的研究人员发现,天然食品添加剂中的一种化合物——胭脂树橙,可以防止小鼠癌细胞的形成和紫外线对皮肤的损伤。

胭脂树橙是橙红色化合物,主要存在于红木、天然调味品和食品着色的胭脂树果实的种子;是拉丁美洲烹饪的常见成分。

wondrak博士的实验室致力于找到食物中可以预防皮肤癌的小分子。张博士是Nrf2转录因子领域的专家,该基因可以加强细胞对抗致癌物。wondrak博士偶尔间发现了胭脂树橙可以激活Nrf2通路,为确定胭脂树橙能否预防癌症,他俩进行了合作。

研究设计很简单,两组老鼠,一组腹腔注射胭脂树橙,一组为对照组未注射,同时暴露于相同的紫外线辐射下。研究者发现,注射胭脂树橙的老鼠,其皮肤损伤情况更轻。

wondrak博士认为这一发现是独一无二的,胭脂树橙是一种营养因素,不是涂在皮肤上的防晒霜,但是它可以防止紫外线对皮肤造成的伤害,通过诱导细胞产生抗氧化作用和修复因子作用。该化合物并没有杀死皮肤癌细胞,但防止其形成。wondrak博士和张博士的此篇研究尤其受人注目,因为它涉及到一个普遍食用的食物。

原始出处:

Systemic administration of the apocarotenoid bixin protects skin against solar UV-induced damage through activation of NRF2.. Tao S, Park SL, de la Vega MR, Zhang DD, Wondrak GT. Free Radical Biology and Medicine. DOI.10.1016/j.freeradbiomed. Published online December 2015.

University of Arizona researchers identify food additive that may prevent skin cancer

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[GetPortalCommentsPageByObjectIdResponse(id=1809805, encodeId=28781809805b7, content=<a href='/topic/show?id=237a8383ea9' target=_blank style='color:#2F92EE;'>#胭脂树橙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83837, encryptionId=237a8383ea9, topicName=胭脂树橙)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=72bf2500198, createdName=小小小向日葵, createdTime=Fri Apr 29 23:35:00 CST 2016, time=2016-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1774615, encodeId=58051e74615ac, content=<a href='/topic/show?id=0c0e1009e3a8' target=_blank style='color:#2F92EE;'>#食品添加剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100973, encryptionId=0c0e1009e3a8, topicName=食品添加剂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=512c38628435, createdName=liuhuangbo, createdTime=Mon Oct 03 05:35:00 CST 2016, time=2016-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1766997, encodeId=659e1e66997ed, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Thu Dec 08 15:35:00 CST 2016, time=2016-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1858656, encodeId=865518586567a, content=<a href='/topic/show?id=e0a9593596' target=_blank style='color:#2F92EE;'>#DIC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, 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objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sat Mar 19 08:35:00 CST 2016, time=2016-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1792939, encodeId=cdd31e9293914, content=<a href='/topic/show?id=b6cd15080b9' target=_blank style='color:#2F92EE;'>#Radical#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15080, encryptionId=b6cd15080b9, topicName=Radical)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJnkE6UvGFfMS41qV0RicWvVTTeLMicqibeZH5GqO4YhNicyl1Y9jFhylIUBn9ntPYy9jhk5hrfic5cRYw/132, createdBy=5f822500020, createdName=ms5236388012055669, createdTime=Wed Dec 28 11:35:00 CST 2016, time=2016-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577458, encodeId=b65b15e745872, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Wed Feb 03 07:35:00 CST 2016, time=2016-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606839, encodeId=0e0216068393a, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Wed Feb 03 07:35:00 CST 2016, time=2016-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1613770, encodeId=336d1613e7042, content=<a href='/topic/show?id=b34d662091f' target=_blank style='color:#2F92EE;'>#添加剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66209, encryptionId=b34d662091f, topicName=添加剂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2d9e19427308, createdName=ms6832696159214430, createdTime=Wed Feb 03 07:35:00 CST 2016, time=2016-02-03, status=1, ipAttribution=)]
    2016-07-06 jeanqiuqiu
  5. 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11:35:00 CST 2016, time=2016-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577458, encodeId=b65b15e745872, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Wed Feb 03 07:35:00 CST 2016, time=2016-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606839, encodeId=0e0216068393a, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Wed Feb 03 07:35:00 CST 2016, time=2016-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1613770, encodeId=336d1613e7042, content=<a href='/topic/show?id=b34d662091f' target=_blank style='color:#2F92EE;'>#添加剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66209, encryptionId=b34d662091f, topicName=添加剂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2d9e19427308, createdName=ms6832696159214430, createdTime=Wed Feb 03 07:35:00 CST 2016, time=2016-02-03, status=1, ipAttribution=)]
    2016-05-03 kalseyzl
  6. 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topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Wed Feb 03 07:35:00 CST 2016, time=2016-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1613770, encodeId=336d1613e7042, content=<a href='/topic/show?id=b34d662091f' target=_blank style='color:#2F92EE;'>#添加剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66209, encryptionId=b34d662091f, topicName=添加剂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2d9e19427308, createdName=ms6832696159214430, createdTime=Wed Feb 03 07:35:00 CST 2016, time=2016-02-03, status=1, ipAttribution=)]
    2016-03-19 sunylz
  7. 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  8. 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  9. 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