PLOS ONE:Roux-en-Y胃旁路手术后体重下降有新解释

2015-08-12 崔倩 译 MedSci原创

胃旁路手术往往导致持续体重下降。Sahlgrenska学院的研究人员已经找到了部分的解释:手术增强能量消耗,例如,实际上吃饭就有助于人们的体重损失。   持续体重损失是一个棘手的问题。手术具有长期效果是病态肥胖的情况下首选的方法。胃旁路手术改变并重新变更了食物经过胃和直接十二指肠到小肠的途径。人们变得吃饱更快,并且倾向于吃更多的有营养的食品。总体影响是有效的减肥。但热量摄入减少

胃旁路手术往往导致持续体重下降。Sahlgrenska学院的研究人员已经找到了部分的解释:手术增强能量消耗,例如,实际上吃饭就有助于人们的体重损失。
   
持续体重损失是一个棘手的问题。手术具有长期效果是病态肥胖的情况下首选的方法。胃旁路手术改变并重新变更了食物经过胃和直接十二指肠到小肠的途径。人们变得吃饱更快,并且倾向于吃更多的有营养的食品。

总体影响是有效的减肥。但热量摄入减少并不能对胃旁路患者长期保持体重下降进行完整的解释。

一项由Sahlgrenska学院的研究人员领导的研究发表在PLoS ONE上,已经解开了这个谜团:该手术会导致能量消耗增加进餐。

“胃旁路手术后小肠的部分变得更加活跃,并且需要额外的营养,”Sahlgrenska研究员Malin Werling说。“这样一来,血液吸收的营养成分较少储存为脂肪。你也许会说,人们可能会通过吃来燃烧卡路里。”

该研究通过在手术前和手术后长达两年的代谢室检查进行了分析。参与者在室内共24小时,这就像配备了一个小酒店房间,为了让研究人员研究他们的新陈代谢细节。

大家都已经知道在饭后人体的能量需求增加。胃肠道需要能量来分解和吸收养分。据Sahlgrenska学院的Lars Fändriks教授,研究人员并没有意识到,胃旁路手术强化了这一过程,是这个过程导致体重持续下降。

进一步的研究将跟踪这些胃旁路手术后因能量需求而增加食物摄入量的具体机制。研究人员希望某天这一手段可以通过药物来增加,而不是必须经常由手术来进行。

原始出处:

Malin Werling, Lars Fändriks, Torsten Olbers, Marco Bueter, Lars Sjöström, Hans Lönroth, Ville Wallenius, Kaj Stenlöf, Carel W. le Roux. Roux-en-Y Gastric Bypass Surgery Increases Respiratory Quotient and Energy Expenditure during Food Intake,PLOS ONE, 2015.8.11

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    2015-08-14 shuaijing1986

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