心血管

订阅

MedSci主页 / 所有栏目 / 心血管

PLoS One：FBN-1基因的遗传变异与胸主动脉夹层相关

2014-04-23 高晓方 译 医学论坛网

基因突变胸主动脉夹层
关注

美国耶鲁大学的一项研究表明，FBN-1基因单核苷酸多态性rs2118181与胸主动脉夹层(TAD)具有相关性。论文于4月17日在线发表于 PLoS ONE 。 近期，LeMaire等研究者发现，GWAS研究显示，在FBN-1基因中的两个单核苷酸多态性(rs2118181 和rs10519177)与胸主动脉夹层、胸主动脉瘤(TAA)和胸主动脉瘤或夹层(TAAD)有关。该研究旨在验证上述结果。 此

美国耶鲁大学的一项研究表明，FBN-1基因单核苷酸多态性rs2118181与胸主动脉夹层(TAD)具有相关性。论文于4月17日在线发表于 PLoS ONE 。【原文下载】

近期，LeMaire等研究者发现，GWAS研究显示，在FBN-1基因中的两个单核苷酸多态性(rs2118181 和rs10519177)与胸主动脉夹层、胸主动脉瘤(TAA)和胸主动脉瘤或夹层(TAAD)有关。该研究旨在验证上述结果。

此项研究共纳入637例TAAD患者和275例对照组，其中TAD和胸主动脉瘤(TAA)患者分别为140例和497例。确定受试者的rs2118181和rs10519177基因型。对性别、年龄、研究中心和高血压进行校正之后，利用Logistic回归模型评估基因型与TAD、TAA和TAAD的相关性。

结果显示，rs2118181与TAD具有相关性。与未携带者相比，rs2118181携带者的TAD未校正比值比为1.80;对性别、年龄、研究中心和高血压进行校正之后，TAD比值比为1.87。rs2118181风险变异携带者和未携带者在TAD潜在混淆因素主动脉大小方面并无显著差异(平均主动脉大小为5.56和5.48)。rs2118181与TAA和TAAD无相关性。rs10519177与TAD、TAA和TAAD均无相关性。

原始出处：


Iakoubova OA1, Tong CH1, Rowland CM1, Luke MM1, Garcia VE1, Catanese JJ1, Moomiaie RM2, Sotonyi P3, Ascady G3, Nikas D4, Dedelias P5, Tranquilli M2, Elefteriades JA2.Genetic Variants in FBN-1 and Risk for Thoracic Aortic Aneurysm and Dissection.PLoS One. 2014 Apr 17;9(4):e91437. doi: 10.1371/journal.pone.0091437. eCollection 2014. 【原文下载】

版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言
评论区 (6)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2003969, encodeId=2e9f2003969a5, content=<a href='/topic/show?id=cdac840e95e' target=_blank style='color:#2F92EE;'>#胸主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84079, encryptionId=cdac840e95e, topicName=胸主动脉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Tue Feb 03 09:25:00 CST 2015, time=2015-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1789590, encodeId=413e1e89590ee, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Thu Jun 05 21:25:00 CST 2014, time=2014-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342299, encodeId=da341342299e9, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Fri Apr 25 00:25:00 CST 2014, time=2014-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1377167, encodeId=0d8c13e716707, content=<a href='/topic/show?id=007d9506920' target=_blank style='color:#2F92EE;'>#遗传变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95069, encryptionId=007d9506920, topicName=遗传变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73a3403, createdName=weihongyv, createdTime=Fri Apr 25 00:25:00 CST 2014, time=2014-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414973, encodeId=e99814149e31c, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Fri Apr 25 00:25:00 CST 2014, time=2014-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1519500, encodeId=90da1519500c3, content=<a href='/topic/show?id=b63a3323558' target=_blank style='color:#2F92EE;'>#动脉夹层#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33235, encryptionId=b63a3323558, topicName=动脉夹层)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae5711287462, createdName=mhzhuang@stu.e, createdTime=Fri Apr 25 00:25:00 CST 2014, time=2014-04-25, status=1, ipAttribution=)]
    2015-02-03 智者为医08

    #胸主动脉#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2003969, encodeId=2e9f2003969a5, content=<a href='/topic/show?id=cdac840e95e' target=_blank style='color:#2F92EE;'>#胸主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84079, encryptionId=cdac840e95e, topicName=胸主动脉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Tue Feb 03 09:25:00 CST 2015, time=2015-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1789590, encodeId=413e1e89590ee, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Thu Jun 05 21:25:00 CST 2014, time=2014-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342299, encodeId=da341342299e9, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Fri Apr 25 00:25:00 CST 2014, time=2014-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1377167, encodeId=0d8c13e716707, content=<a href='/topic/show?id=007d9506920' target=_blank style='color:#2F92EE;'>#遗传变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95069, encryptionId=007d9506920, topicName=遗传变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73a3403, createdName=weihongyv, createdTime=Fri Apr 25 00:25:00 CST 2014, time=2014-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414973, encodeId=e99814149e31c, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Fri Apr 25 00:25:00 CST 2014, time=2014-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1519500, encodeId=90da1519500c3, content=<a href='/topic/show?id=b63a3323558' target=_blank style='color:#2F92EE;'>#动脉夹层#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33235, encryptionId=b63a3323558, topicName=动脉夹层)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae5711287462, createdName=mhzhuang@stu.e, createdTime=Fri Apr 25 00:25:00 CST 2014, time=2014-04-25, status=1, ipAttribution=)]
    2014-06-05 119337457

    #Plos one#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2003969, encodeId=2e9f2003969a5, content=<a href='/topic/show?id=cdac840e95e' target=_blank style='color:#2F92EE;'>#胸主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84079, encryptionId=cdac840e95e, topicName=胸主动脉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Tue Feb 03 09:25:00 CST 2015, time=2015-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1789590, encodeId=413e1e89590ee, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Thu Jun 05 21:25:00 CST 2014, time=2014-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342299, encodeId=da341342299e9, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Fri Apr 25 00:25:00 CST 2014, time=2014-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1377167, encodeId=0d8c13e716707, content=<a href='/topic/show?id=007d9506920' target=_blank style='color:#2F92EE;'>#遗传变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95069, encryptionId=007d9506920, topicName=遗传变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73a3403, createdName=weihongyv, createdTime=Fri Apr 25 00:25:00 CST 2014, time=2014-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414973, encodeId=e99814149e31c, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Fri Apr 25 00:25:00 CST 2014, time=2014-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1519500, encodeId=90da1519500c3, content=<a href='/topic/show?id=b63a3323558' target=_blank style='color:#2F92EE;'>#动脉夹层#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33235, encryptionId=b63a3323558, topicName=动脉夹层)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae5711287462, createdName=mhzhuang@stu.e, createdTime=Fri Apr 25 00:25:00 CST 2014, time=2014-04-25, status=1, ipAttribution=)]
    2014-04-25 12498dabm77暂无昵称

    #变异#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2003969, encodeId=2e9f2003969a5, content=<a href='/topic/show?id=cdac840e95e' target=_blank style='color:#2F92EE;'>#胸主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84079, encryptionId=cdac840e95e, topicName=胸主动脉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Tue Feb 03 09:25:00 CST 2015, time=2015-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1789590, encodeId=413e1e89590ee, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Thu Jun 05 21:25:00 CST 2014, time=2014-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342299, encodeId=da341342299e9, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Fri Apr 25 00:25:00 CST 2014, time=2014-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1377167, encodeId=0d8c13e716707, content=<a href='/topic/show?id=007d9506920' target=_blank style='color:#2F92EE;'>#遗传变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95069, encryptionId=007d9506920, topicName=遗传变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73a3403, createdName=weihongyv, createdTime=Fri Apr 25 00:25:00 CST 2014, time=2014-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414973, encodeId=e99814149e31c, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Fri Apr 25 00:25:00 CST 2014, time=2014-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1519500, encodeId=90da1519500c3, content=<a href='/topic/show?id=b63a3323558' target=_blank style='color:#2F92EE;'>#动脉夹层#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33235, encryptionId=b63a3323558, topicName=动脉夹层)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae5711287462, createdName=mhzhuang@stu.e, createdTime=Fri Apr 25 00:25:00 CST 2014, time=2014-04-25, status=1, ipAttribution=)]
    2014-04-25 weihongyv

    #遗传变异#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2003969, encodeId=2e9f2003969a5, content=<a href='/topic/show?id=cdac840e95e' target=_blank style='color:#2F92EE;'>#胸主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84079, encryptionId=cdac840e95e, topicName=胸主动脉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Tue Feb 03 09:25:00 CST 2015, time=2015-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1789590, encodeId=413e1e89590ee, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Thu Jun 05 21:25:00 CST 2014, time=2014-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342299, encodeId=da341342299e9, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Fri Apr 25 00:25:00 CST 2014, time=2014-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1377167, encodeId=0d8c13e716707, content=<a href='/topic/show?id=007d9506920' target=_blank style='color:#2F92EE;'>#遗传变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95069, encryptionId=007d9506920, topicName=遗传变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73a3403, createdName=weihongyv, createdTime=Fri Apr 25 00:25:00 CST 2014, time=2014-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414973, encodeId=e99814149e31c, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Fri Apr 25 00:25:00 CST 2014, time=2014-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1519500, encodeId=90da1519500c3, content=<a href='/topic/show?id=b63a3323558' target=_blank style='color:#2F92EE;'>#动脉夹层#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33235, encryptionId=b63a3323558, topicName=动脉夹层)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae5711287462, createdName=mhzhuang@stu.e, createdTime=Fri Apr 25 00:25:00 CST 2014, time=2014-04-25, status=1, ipAttribution=)]
    2014-04-25 circumcision

    #主动脉#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2003969, encodeId=2e9f2003969a5, content=<a href='/topic/show?id=cdac840e95e' target=_blank style='color:#2F92EE;'>#胸主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84079, encryptionId=cdac840e95e, topicName=胸主动脉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Tue Feb 03 09:25:00 CST 2015, time=2015-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1789590, encodeId=413e1e89590ee, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Thu Jun 05 21:25:00 CST 2014, time=2014-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342299, encodeId=da341342299e9, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Fri Apr 25 00:25:00 CST 2014, time=2014-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1377167, encodeId=0d8c13e716707, content=<a href='/topic/show?id=007d9506920' target=_blank style='color:#2F92EE;'>#遗传变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95069, encryptionId=007d9506920, topicName=遗传变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73a3403, createdName=weihongyv, createdTime=Fri Apr 25 00:25:00 CST 2014, time=2014-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414973, encodeId=e99814149e31c, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Fri Apr 25 00:25:00 CST 2014, time=2014-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1519500, encodeId=90da1519500c3, content=<a href='/topic/show?id=b63a3323558' target=_blank style='color:#2F92EE;'>#动脉夹层#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33235, encryptionId=b63a3323558, topicName=动脉夹层)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae5711287462, createdName=mhzhuang@stu.e, createdTime=Fri Apr 25 00:25:00 CST 2014, time=2014-04-25, status=1, ipAttribution=)]
    2014-04-25 mhzhuang@stu.e

    #动脉夹层#

    0

相关资讯

Cell：H5N1被发现仅需5次基因突变便能人际传播

荷兰研究人员近日发现，H5N1禽流感病毒只需经5次基因突变就能像普通流感一样，通过咳嗽和打喷嚏进行空气传播。 该项研究刊登在周四《细胞》杂志中。荷兰鹿特丹市伊拉斯姆斯大学医学中心的病毒学家Ron Fouchier称，这并不代表H5N1病毒会更有可能成为人感染人的流行性疾病，但同时也不能排除这种可能性的存在。 Ron的团队曾在雪貂身上做测试，发现病毒株需经9次以上的基因突变才

Nat Genet：癌基因组独特印记的根源

所有的致癌过程都会在患者的基因组上留下独特的突变印记。来自韦尔科姆基金会桑格学院研究所（Wellcome Trust Sanger Institute）的一个研究小组发现了一个重要的生物学证据，支持了一组抗病毒基因在癌症形成中起作用。由这一基因家族驱动的致癌过程所留下的突变标记存在于一半的癌症类型之中。 我们对于引起癌症的生物过程所知有限。紫外线和吸烟是众所周知的两个致癌过程。暴露于其中任一

Nat Genet：罕见基因突变可防止患II型糖尿病

据美国媒体报道，新发表的一项研究发现，一种罕见的基因突变可以防止人们患上II型糖尿病，可将患病风险降低了三分之二，如此显着的效果为制药公司开辟了一个新的前景：开发一种药物来模仿这种基因突变的效果。据报道，这项新研究是以15万人的基因测试结果为基础进行的。产生胰岛素的胰细胞使用的一个基因遭到这种突变的破坏。有这种基因变异的人产生的胰岛素比正常人略多，一生中的血糖水平都较普通人略低。美国两家公司表示，

PNAS：乳腺癌基因涉及大脑尺寸控制

一项研究提出，一个涉及乳腺和卵巢癌风险的基因BRCA1可能在控制哺乳动物的大脑尺寸方面起到了作用。乳腺癌易感基因1（BRCA1）是一个肿瘤抑制基因，已知它能够影响乳腺和卵巢癌风险，但是能帮助修复DNA损伤的BRCA1蛋白质在胚胎的频繁分裂的神经上皮细胞和干细胞中高度表达。 为了确定BRCA1在胚胎神经前体中的功能重要性，Inder Verma及其同事培育出了胚胎大脑缺乏BRCA1的转基因小鼠

Cancer Cell：致癌突变的关键执行者

科学家们发现，肠癌中的许多重要致癌基因都通过一种microRNA起作用，这一核心分子将成为相关药物开发的关键。文章于四月十四日发表在Cancer Cell杂志上。研究指出，靶标这种microRNA的药物可以同时阻断多个致癌突变的影响，此外这种分子的水平还可以帮助人们预测肠癌的侵袭性。格拉斯哥大学和俄亥俄州立大学的研究人员，检测了485名肠癌患者体内的microRNA 135b水平。他们发现，这种分

Nature：癌症研究正处于十字路口

自 20 世纪 70 年代发现第一个致癌基因以来，人们一直渴望列出所有会引发癌症的突变。每一个这样的突变都可能拓展我们对癌症病因的理解，进而推动癌症的治疗。现在，癌症研究正处于关键的十字路口，对此本期 Nature 杂志特别发表了编辑文章，展望了癌症基因组研究的未来。 上周，有 18400 人参加了在加州召开的美国癌症研究学会（AACR）年会。研究人员在会上展示，突变模式可以帮助人们追溯它们的成