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Cell：MYC基因让人更长寿，更健康

2015-02-03 王姗编译 中国医学论坛报

MYC基因低表达小鼠更长寿更健康
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1月22日，《细胞》(Cell)杂志在线发表了由中国学者赵小艾等作为共同第一作者所完成的研究“MYC基因表达降低与长寿和长期健康相关”。 MYC是一种高度多效性的转录因子，其异常活化可促发癌症。该研究发现Myc杂合子(Myc+/-)雌雄小鼠与对照组正常Myc纯合子(Myc+/+)小鼠相比，寿命均有显著延长，其中雌性老鼠寿命延长20%，雄性老鼠寿命延长10%。此外，Myc杂合子小鼠较正常小

1月22日，《细胞》(Cell)杂志在线发表了由中国学者赵小艾等作为共同第一作者所完成的研究“MYC基因表达降低与长寿和长期健康相关”。


MYC是一种高度多效性的转录因子，其异常活化可促发癌症。该研究发现Myc杂合子(Myc+/-)雌雄小鼠与对照组正常Myc纯合子(Myc+/+)小鼠相比，寿命均有显著延长，其中雌性老鼠寿命延长20%，雄性老鼠寿命延长10%。此外，Myc杂合子小鼠较正常小鼠更为健康，与衰老相关的病理改变和疾病显著下降，包括骨质疏松、心脏纤维化和免疫衰老;其表现更为活跃，代谢率更高，脂代谢也更为健康，转录组学分析显示其代谢和免疫过程中的基因表达特征丰富。

研究者发现Myc杂合子小鼠的蛋白翻译速率明显变慢，认为其长寿很大程度上可被解释为Myc在蛋白翻译中起重要作用，因Myc直接调节的基因都直接调控核糖体的形成和蛋白质翻译。Myc杂合子小鼠的营养与能量传感通路亦有改变，包括血清胰岛素样生长因子(IGF)-1水平降低、单磷酸腺苷依赖的蛋白激酶(AMPK)活性增加以及蛋白激酶B(AKT)、雷帕霉素靶蛋白(TOR)和核糖体蛋白S6激酶(S6K)活性降低。与其他长寿模型相比，Myc杂合子小鼠未显示出压力管理通路的改善。

原始出处：

Hofmann JW1, Zhao X1, De Cecco M1, Peterson AL1, Pagliaroli L1, Manivannan J1, Hubbard GB2, Ikeno Y2, Zhang Y3, Feng B4, Li X5, Serre T5, Qi W2, Van Remmen H2, Miller RA6, Bath KG5, de Cabo R3, Xu H4, Neretti N1, Sedivy JM7.Reduced Expression of MYC Increases Longevity and Enhances Healthspan.Cell. 2015 Jan 29;160(3):477-88. doi: 10.1016/j.cell.2014.12.016. Epub 2015 Jan 22.

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1959264, encodeId=d3d4195926406, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Tue Aug 11 21:37:00 CST 2015, time=2015-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32170, encodeId=7e0d321e097, content=中国学者, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhRUzmFEmHvdIaOns4DmF3BicVffXjkOjBTiaMUIA4o7feGvE5IJ0SfSco4ib955Rx7bvWlib7j9V15xp/0, createdBy=814d1631326, createdName=cmn, createdTime=Thu Jul 09 21:03:00 CST 2015, time=2015-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1869013, encodeId=05b218690136d, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Jan 07 20:37:00 CST 2016, time=2016-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15374, encodeId=4684153e41f, content=犹如利剑，有利有弊。目前看弊大于利---, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=49.93.198.**, createdTime=Fri Feb 13 09:56:00 CST 2015, time=2015-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15367, encodeId=c0c31536e34, content=长知识！, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e4c1614170, createdName=hhcommandos, createdTime=Thu Feb 12 18:03:00 CST 2015, time=2015-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1274790, encodeId=b0a312e4790eb, content=<a href='/topic/show?id=1bbc12404ba' target=_blank style='color:#2F92EE;'>#MYC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12404, encryptionId=1bbc12404ba, topicName=MYC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Thu Feb 05 00:37:00 CST 2015, time=2015-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15014, encodeId=e3fb15014a5, content=在人组织内检测过该基因否？, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12e61613707, createdName=laogao, createdTime=Tue Feb 03 18:11:00 CST 2015, time=2015-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15008, encodeId=301a1500896, content=肿瘤，长寿，衰老是矛盾的。抗衰老就可能致癌！myc是原癌基因，但可令人长寿, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=223.104.5.**, createdTime=Tue Feb 03 17:27:00 CST 2015, time=2015-02-03, status=1, ipAttribution=)]
    2015-08-11 维他命

    #CEL#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1959264, encodeId=d3d4195926406, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Tue Aug 11 21:37:00 CST 2015, time=2015-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32170, encodeId=7e0d321e097, content=中国学者, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhRUzmFEmHvdIaOns4DmF3BicVffXjkOjBTiaMUIA4o7feGvE5IJ0SfSco4ib955Rx7bvWlib7j9V15xp/0, createdBy=814d1631326, createdName=cmn, createdTime=Thu Jul 09 21:03:00 CST 2015, time=2015-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1869013, encodeId=05b218690136d, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Jan 07 20:37:00 CST 2016, time=2016-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15374, encodeId=4684153e41f, content=犹如利剑，有利有弊。目前看弊大于利---, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=49.93.198.**, createdTime=Fri Feb 13 09:56:00 CST 2015, time=2015-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15367, encodeId=c0c31536e34, content=长知识！, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e4c1614170, createdName=hhcommandos, createdTime=Thu Feb 12 18:03:00 CST 2015, time=2015-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1274790, encodeId=b0a312e4790eb, content=<a href='/topic/show?id=1bbc12404ba' target=_blank style='color:#2F92EE;'>#MYC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12404, encryptionId=1bbc12404ba, topicName=MYC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Thu Feb 05 00:37:00 CST 2015, time=2015-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15014, encodeId=e3fb15014a5, content=在人组织内检测过该基因否？, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12e61613707, createdName=laogao, createdTime=Tue Feb 03 18:11:00 CST 2015, time=2015-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15008, encodeId=301a1500896, content=肿瘤，长寿，衰老是矛盾的。抗衰老就可能致癌！myc是原癌基因，但可令人长寿, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=223.104.5.**, createdTime=Tue Feb 03 17:27:00 CST 2015, time=2015-02-03, status=1, ipAttribution=)]
    2015-07-09 cmn

    中国学者

    0

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    2016-01-07 zhaozhouchifen

    #Cell#

    0

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    2015-02-13 49.93.198.**

    犹如利剑，有利有弊。目前看弊大于利---

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1959264, encodeId=d3d4195926406, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Tue Aug 11 21:37:00 CST 2015, time=2015-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32170, encodeId=7e0d321e097, content=中国学者, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhRUzmFEmHvdIaOns4DmF3BicVffXjkOjBTiaMUIA4o7feGvE5IJ0SfSco4ib955Rx7bvWlib7j9V15xp/0, createdBy=814d1631326, createdName=cmn, createdTime=Thu Jul 09 21:03:00 CST 2015, time=2015-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1869013, encodeId=05b218690136d, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Jan 07 20:37:00 CST 2016, time=2016-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15374, encodeId=4684153e41f, content=犹如利剑，有利有弊。目前看弊大于利---, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=49.93.198.**, createdTime=Fri Feb 13 09:56:00 CST 2015, time=2015-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15367, encodeId=c0c31536e34, content=长知识！, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e4c1614170, createdName=hhcommandos, createdTime=Thu Feb 12 18:03:00 CST 2015, time=2015-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1274790, encodeId=b0a312e4790eb, content=<a href='/topic/show?id=1bbc12404ba' target=_blank style='color:#2F92EE;'>#MYC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12404, encryptionId=1bbc12404ba, topicName=MYC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Thu Feb 05 00:37:00 CST 2015, time=2015-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15014, encodeId=e3fb15014a5, content=在人组织内检测过该基因否？, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12e61613707, createdName=laogao, createdTime=Tue Feb 03 18:11:00 CST 2015, time=2015-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15008, encodeId=301a1500896, content=肿瘤，长寿，衰老是矛盾的。抗衰老就可能致癌！myc是原癌基因，但可令人长寿, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=223.104.5.**, createdTime=Tue Feb 03 17:27:00 CST 2015, time=2015-02-03, status=1, ipAttribution=)]
    2015-02-12 hhcommandos

    长知识！

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1959264, encodeId=d3d4195926406, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Tue Aug 11 21:37:00 CST 2015, time=2015-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32170, encodeId=7e0d321e097, content=中国学者, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhRUzmFEmHvdIaOns4DmF3BicVffXjkOjBTiaMUIA4o7feGvE5IJ0SfSco4ib955Rx7bvWlib7j9V15xp/0, createdBy=814d1631326, createdName=cmn, createdTime=Thu Jul 09 21:03:00 CST 2015, time=2015-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1869013, encodeId=05b218690136d, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Jan 07 20:37:00 CST 2016, time=2016-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15374, encodeId=4684153e41f, content=犹如利剑，有利有弊。目前看弊大于利---, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=49.93.198.**, createdTime=Fri Feb 13 09:56:00 CST 2015, time=2015-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15367, encodeId=c0c31536e34, content=长知识！, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e4c1614170, createdName=hhcommandos, createdTime=Thu Feb 12 18:03:00 CST 2015, time=2015-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1274790, encodeId=b0a312e4790eb, content=<a href='/topic/show?id=1bbc12404ba' target=_blank style='color:#2F92EE;'>#MYC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12404, encryptionId=1bbc12404ba, topicName=MYC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Thu Feb 05 00:37:00 CST 2015, time=2015-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15014, encodeId=e3fb15014a5, content=在人组织内检测过该基因否？, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12e61613707, createdName=laogao, createdTime=Tue Feb 03 18:11:00 CST 2015, time=2015-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15008, encodeId=301a1500896, content=肿瘤，长寿，衰老是矛盾的。抗衰老就可能致癌！myc是原癌基因，但可令人长寿, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=223.104.5.**, createdTime=Tue Feb 03 17:27:00 CST 2015, time=2015-02-03, status=1, ipAttribution=)]
    2015-02-05 guihongzh

    #MYC#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1959264, encodeId=d3d4195926406, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Tue Aug 11 21:37:00 CST 2015, time=2015-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32170, encodeId=7e0d321e097, content=中国学者, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhRUzmFEmHvdIaOns4DmF3BicVffXjkOjBTiaMUIA4o7feGvE5IJ0SfSco4ib955Rx7bvWlib7j9V15xp/0, createdBy=814d1631326, createdName=cmn, createdTime=Thu Jul 09 21:03:00 CST 2015, time=2015-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1869013, encodeId=05b218690136d, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Jan 07 20:37:00 CST 2016, time=2016-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15374, encodeId=4684153e41f, content=犹如利剑，有利有弊。目前看弊大于利---, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=49.93.198.**, createdTime=Fri Feb 13 09:56:00 CST 2015, time=2015-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15367, encodeId=c0c31536e34, content=长知识！, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e4c1614170, createdName=hhcommandos, createdTime=Thu Feb 12 18:03:00 CST 2015, time=2015-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1274790, encodeId=b0a312e4790eb, content=<a href='/topic/show?id=1bbc12404ba' target=_blank style='color:#2F92EE;'>#MYC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12404, encryptionId=1bbc12404ba, topicName=MYC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Thu Feb 05 00:37:00 CST 2015, time=2015-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15014, encodeId=e3fb15014a5, content=在人组织内检测过该基因否？, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12e61613707, createdName=laogao, createdTime=Tue Feb 03 18:11:00 CST 2015, time=2015-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15008, encodeId=301a1500896, content=肿瘤，长寿，衰老是矛盾的。抗衰老就可能致癌！myc是原癌基因，但可令人长寿, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=223.104.5.**, createdTime=Tue Feb 03 17:27:00 CST 2015, time=2015-02-03, status=1, ipAttribution=)]
    2015-02-03 laogao

    在人组织内检测过该基因否？

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1959264, encodeId=d3d4195926406, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Tue Aug 11 21:37:00 CST 2015, time=2015-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=32170, encodeId=7e0d321e097, content=中国学者, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhRUzmFEmHvdIaOns4DmF3BicVffXjkOjBTiaMUIA4o7feGvE5IJ0SfSco4ib955Rx7bvWlib7j9V15xp/0, createdBy=814d1631326, createdName=cmn, createdTime=Thu Jul 09 21:03:00 CST 2015, time=2015-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1869013, encodeId=05b218690136d, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Jan 07 20:37:00 CST 2016, time=2016-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15374, encodeId=4684153e41f, content=犹如利剑，有利有弊。目前看弊大于利---, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=49.93.198.**, createdTime=Fri Feb 13 09:56:00 CST 2015, time=2015-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15367, encodeId=c0c31536e34, content=长知识！, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e4c1614170, createdName=hhcommandos, createdTime=Thu Feb 12 18:03:00 CST 2015, time=2015-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1274790, encodeId=b0a312e4790eb, content=<a href='/topic/show?id=1bbc12404ba' target=_blank style='color:#2F92EE;'>#MYC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12404, encryptionId=1bbc12404ba, topicName=MYC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Thu Feb 05 00:37:00 CST 2015, time=2015-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15014, encodeId=e3fb15014a5, content=在人组织内检测过该基因否？, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12e61613707, createdName=laogao, createdTime=Tue Feb 03 18:11:00 CST 2015, time=2015-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=15008, encodeId=301a1500896, content=肿瘤，长寿，衰老是矛盾的。抗衰老就可能致癌！myc是原癌基因，但可令人长寿, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=223.104.5.**, createdTime=Tue Feb 03 17:27:00 CST 2015, time=2015-02-03, status=1, ipAttribution=)]
    2015-02-03 223.104.5.**

    肿瘤，长寿，衰老是矛盾的。抗衰老就可能致癌！myc是原癌基因，但可令人长寿

    0