J Periodontol: 原发性Sjogren综合征和类风湿性关节炎的临床牙周状况及炎性细胞因子

2018-08-19 MedSci MedSci原创

本研究的目的是比较原发性Sjogren综合征(pSS)和类风湿性关节炎(RA)受试者中临床牙周发现以及肿瘤坏死因子-α(TNF-α),白细胞介素-1β(IL-1β),干扰素γ(IFN)和caspase-1的龈沟液(GCF)和血浆水平。

本研究的目的是比较原发性Sjogren综合征(pSS)和类风湿性关节炎(RA)受试者中临床牙周发现以及肿瘤坏死因子-α(TNF-α),白细胞介素-1β(IL-1β),干扰素γ(IFN)和caspase-1的龈沟液(GCF)和血浆水平。

方法:收集对照研究血浆和GCF样本,在44名患有pSS的受试者,39名RA患者和30名健康受试者中进行包括菌斑指数(PI),探诊出血(BOP)和探诊深度(PD)的全口记录。通过酶联免疫吸附测定法测定血浆和GCF中 TNF-α,IL-1β,IFN-γ和半胱天冬酶-1水平。

结果:所有研究组的GCF和血浆中的IFN-γ和TNF-α水平无差异(p> 0.05)。 pSS组IL-1β的GCF水平高于健康组(p = 0.035)。 pSS组Caspase-1 的GCF水平显着高于RA组(p = 0.032)。与RA和健康组相比,在pSS中检测到最高的血浆IL-1β水平(p <0.001)。健康组的caspase-1血浆水平高于pSS和RA组(p <0.001)。

本研究显示,pSS患者的牙周状况与全身健康的受试者没有差异。还需要进一步研究,并制定标准化患者入选标准,以确认结果。

原始出处:

Ozgun Ozcaka, et al. Clinical periodontal status and inflammatory cytokines in primary Sjogren syndrome and rheumatoid arthritis. Journal of Periodontology. 2018 August. doi:10.1002/JPER.17-0730

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  5. 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channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Tue Aug 21 10:40:00 CST 2018, time=2018-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1483535, encodeId=14d21483535da, content=<a href='/topic/show?id=55a6100826cc' target=_blank style='color:#2F92EE;'>#风湿性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100826, encryptionId=55a6100826cc, topicName=风湿性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c237911872, createdName=ms1467340776200723, createdTime=Tue Aug 21 10:40:00 CST 2018, time=2018-08-21, status=1, ipAttribution=)]
    2018-08-21 lmm397
  6. 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  7. 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