CJASN:控制尿蛋白和血压是防止IgA肾病进展的关键

2014-02-18 佚名 医师报

北京大学第一医院肾内科吕继成教授等开展的一项前瞻性研究表明,对于我国IgA肾病患者,有效控制尿蛋白和血压是预防估算肾小球滤过率(eGFR)下降和终末期肾病的关键措施。 研究者指出,目前IgA肾病的治疗措施主要包括肾素-血管紧张素系统阻滞剂和激素。在该研究中,703例IgA肾病患者至少接受 12 个月随访,平均随访 45个月。受试者的eGFR年下降速度为3.12 m

北京大学第一医院肾内科吕继成教授等开展的一项前瞻性研究表明,对于我国IgA肾病患者,有效控制尿蛋白和血压是预防估算肾小球滤过率(eGFR)下降和终末期肾病的关键措施。

研究者指出,目前IgA肾病的治疗措施主要包括肾素-血管紧张素系统阻滞剂和激素。在该研究中,703例IgA肾病患者至少接受 12 个月随访,平均随访 45个月。受试者的eGFR年下降速度为3.12 ml/min/1.73 m2,终末期肾衰竭年发生率为2.3%。

多因素Cox回归分析显示,基线eGFR、6个月时尿蛋白和收缩压控制情况都与肾衰竭有关:基线eGFR每升高10 ml/min/1.73 m2,肾衰竭风险降低24%;尿蛋白每增加1 g/d,肾衰竭风险增加53%;收缩压每升高10 mm Hg,肾衰竭风险增加36%。

原始出处:

Li X, Liu Y, Lv J, Shi S, Liu L, Chen Y, Zhang H.Progression of IgA Nephropathy under Current Therapy Regimen in a Chinese Population.Clin J Am Soc Nephrol. 2014 Jan 9. 

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    2015-08-06 sundong

    所以要控制好

    0

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    2015-02-27 xiaoai5777

    好文章,超赞

    0

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    2014-11-18 chenhongpeng
  5. [GetPortalCommentsPageByObjectIdResponse(id=35051, encodeId=4fd23505104, content=所以要控制好, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3ykRSkuxjt93yc9tvDWfIQItrwiaKSCps5kyrTyDlwic2FgoCWe88wR3ZiaggKYGueDIp26zVgnbzriaQ/0, createdBy=89d71602869, createdName=sundong, createdTime=Thu Aug 06 22:47:00 CST 2015, time=2015-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17173, encodeId=83f91e173f8, content=好文章,超赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Fri Feb 27 23:24:00 CST 2015, time=2015-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1808910, encodeId=8b5c18089107f, content=<a href='/topic/show?id=c5b68259068' target=_blank style='color:#2F92EE;'>#肾病进展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82590, encryptionId=c5b68259068, topicName=肾病进展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3eaf430, createdName=bsmagic9132, createdTime=Thu Jan 22 18:23:00 CST 2015, time=2015-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1941243, encodeId=a21519412431d, content=<a href='/topic/show?id=bd2f28e0e1' target=_blank style='color:#2F92EE;'>#ASN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2870, encryptionId=bd2f28e0e1, topicName=ASN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1777154, createdName=chenhongpeng, createdTime=Tue Nov 18 10:23:00 CST 2014, time=2014-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783227, encodeId=4a1d1e8322729, content=<a href='/topic/show?id=2f7d4e816b' target=_blank style='color:#2F92EE;'>#CJASN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4781, encryptionId=2f7d4e816b, topicName=CJASN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f34c147, createdName=ay2000fy, createdTime=Sat May 24 15:23:00 CST 2014, time=2014-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332278, encodeId=2b9f13322e808, content=<a href='/topic/show?id=33994e50466' target=_blank style='color:#2F92EE;'>#尿蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47504, encryptionId=33994e50466, topicName=尿蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8dca2500075, createdName=396094184_42047355, createdTime=Thu Feb 20 00:23:00 CST 2014, time=2014-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414592, encodeId=59d41414592d3, content=<a href='/topic/show?id=c83e94827d' target=_blank style='color:#2F92EE;'>#IgA肾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9482, encryptionId=c83e94827d, topicName=IgA肾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd7c3073380, createdName=huiwelcome, createdTime=Thu Feb 20 00:23:00 CST 2014, time=2014-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1503882, encodeId=48df1503882c5, content=<a href='/topic/show?id=641d94e7eb' target=_blank style='color:#2F92EE;'>#IgA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9477, encryptionId=641d94e7eb, topicName=IgA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c23f9697922, createdName=yibei, createdTime=Thu Feb 20 00:23:00 CST 2014, time=2014-02-20, status=1, ipAttribution=)]
    2014-05-24 ay2000fy
  6. [GetPortalCommentsPageByObjectIdResponse(id=35051, encodeId=4fd23505104, content=所以要控制好, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3ykRSkuxjt93yc9tvDWfIQItrwiaKSCps5kyrTyDlwic2FgoCWe88wR3ZiaggKYGueDIp26zVgnbzriaQ/0, createdBy=89d71602869, createdName=sundong, createdTime=Thu Aug 06 22:47:00 CST 2015, time=2015-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17173, encodeId=83f91e173f8, content=好文章,超赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Fri Feb 27 23:24:00 CST 2015, time=2015-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1808910, encodeId=8b5c18089107f, content=<a href='/topic/show?id=c5b68259068' target=_blank style='color:#2F92EE;'>#肾病进展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82590, encryptionId=c5b68259068, topicName=肾病进展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3eaf430, createdName=bsmagic9132, createdTime=Thu Jan 22 18:23:00 CST 2015, time=2015-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1941243, encodeId=a21519412431d, content=<a href='/topic/show?id=bd2f28e0e1' target=_blank style='color:#2F92EE;'>#ASN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2870, encryptionId=bd2f28e0e1, topicName=ASN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1777154, createdName=chenhongpeng, createdTime=Tue Nov 18 10:23:00 CST 2014, time=2014-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783227, encodeId=4a1d1e8322729, content=<a href='/topic/show?id=2f7d4e816b' target=_blank style='color:#2F92EE;'>#CJASN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4781, encryptionId=2f7d4e816b, topicName=CJASN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f34c147, createdName=ay2000fy, createdTime=Sat May 24 15:23:00 CST 2014, time=2014-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332278, encodeId=2b9f13322e808, content=<a href='/topic/show?id=33994e50466' target=_blank style='color:#2F92EE;'>#尿蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47504, encryptionId=33994e50466, topicName=尿蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8dca2500075, createdName=396094184_42047355, createdTime=Thu Feb 20 00:23:00 CST 2014, time=2014-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414592, encodeId=59d41414592d3, content=<a href='/topic/show?id=c83e94827d' target=_blank style='color:#2F92EE;'>#IgA肾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9482, encryptionId=c83e94827d, topicName=IgA肾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd7c3073380, createdName=huiwelcome, createdTime=Thu Feb 20 00:23:00 CST 2014, time=2014-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1503882, encodeId=48df1503882c5, content=<a href='/topic/show?id=641d94e7eb' target=_blank style='color:#2F92EE;'>#IgA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9477, encryptionId=641d94e7eb, topicName=IgA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c23f9697922, createdName=yibei, createdTime=Thu Feb 20 00:23:00 CST 2014, time=2014-02-20, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=35051, encodeId=4fd23505104, content=所以要控制好, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3ykRSkuxjt93yc9tvDWfIQItrwiaKSCps5kyrTyDlwic2FgoCWe88wR3ZiaggKYGueDIp26zVgnbzriaQ/0, createdBy=89d71602869, createdName=sundong, createdTime=Thu Aug 06 22:47:00 CST 2015, time=2015-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17173, encodeId=83f91e173f8, content=好文章,超赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Fri Feb 27 23:24:00 CST 2015, time=2015-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1808910, encodeId=8b5c18089107f, content=<a href='/topic/show?id=c5b68259068' target=_blank style='color:#2F92EE;'>#肾病进展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82590, encryptionId=c5b68259068, topicName=肾病进展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3eaf430, createdName=bsmagic9132, createdTime=Thu Jan 22 18:23:00 CST 2015, time=2015-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1941243, encodeId=a21519412431d, content=<a href='/topic/show?id=bd2f28e0e1' target=_blank style='color:#2F92EE;'>#ASN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2870, encryptionId=bd2f28e0e1, topicName=ASN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1777154, createdName=chenhongpeng, createdTime=Tue Nov 18 10:23:00 CST 2014, time=2014-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783227, encodeId=4a1d1e8322729, content=<a href='/topic/show?id=2f7d4e816b' target=_blank style='color:#2F92EE;'>#CJASN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4781, encryptionId=2f7d4e816b, topicName=CJASN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f34c147, createdName=ay2000fy, createdTime=Sat May 24 15:23:00 CST 2014, time=2014-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332278, encodeId=2b9f13322e808, content=<a href='/topic/show?id=33994e50466' target=_blank style='color:#2F92EE;'>#尿蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47504, encryptionId=33994e50466, topicName=尿蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8dca2500075, createdName=396094184_42047355, createdTime=Thu Feb 20 00:23:00 CST 2014, time=2014-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414592, encodeId=59d41414592d3, content=<a href='/topic/show?id=c83e94827d' target=_blank style='color:#2F92EE;'>#IgA肾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9482, encryptionId=c83e94827d, topicName=IgA肾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd7c3073380, createdName=huiwelcome, createdTime=Thu Feb 20 00:23:00 CST 2014, time=2014-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1503882, encodeId=48df1503882c5, content=<a href='/topic/show?id=641d94e7eb' target=_blank style='color:#2F92EE;'>#IgA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9477, encryptionId=641d94e7eb, topicName=IgA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c23f9697922, createdName=yibei, createdTime=Thu Feb 20 00:23:00 CST 2014, time=2014-02-20, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=35051, encodeId=4fd23505104, content=所以要控制好, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3ykRSkuxjt93yc9tvDWfIQItrwiaKSCps5kyrTyDlwic2FgoCWe88wR3ZiaggKYGueDIp26zVgnbzriaQ/0, createdBy=89d71602869, createdName=sundong, createdTime=Thu Aug 06 22:47:00 CST 2015, time=2015-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17173, encodeId=83f91e173f8, content=好文章,超赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=36a81612921, createdName=xiaoai5777, createdTime=Fri Feb 27 23:24:00 CST 2015, time=2015-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1808910, encodeId=8b5c18089107f, content=<a href='/topic/show?id=c5b68259068' target=_blank style='color:#2F92EE;'>#肾病进展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82590, encryptionId=c5b68259068, topicName=肾病进展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3eaf430, createdName=bsmagic9132, createdTime=Thu Jan 22 18:23:00 CST 2015, time=2015-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1941243, encodeId=a21519412431d, content=<a href='/topic/show?id=bd2f28e0e1' target=_blank style='color:#2F92EE;'>#ASN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2870, encryptionId=bd2f28e0e1, topicName=ASN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1777154, createdName=chenhongpeng, createdTime=Tue Nov 18 10:23:00 CST 2014, time=2014-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783227, encodeId=4a1d1e8322729, content=<a href='/topic/show?id=2f7d4e816b' target=_blank style='color:#2F92EE;'>#CJASN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4781, encryptionId=2f7d4e816b, topicName=CJASN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f34c147, createdName=ay2000fy, createdTime=Sat May 24 15:23:00 CST 2014, time=2014-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1332278, encodeId=2b9f13322e808, content=<a href='/topic/show?id=33994e50466' target=_blank style='color:#2F92EE;'>#尿蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47504, encryptionId=33994e50466, topicName=尿蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8dca2500075, createdName=396094184_42047355, createdTime=Thu Feb 20 00:23:00 CST 2014, time=2014-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1414592, encodeId=59d41414592d3, content=<a href='/topic/show?id=c83e94827d' target=_blank style='color:#2F92EE;'>#IgA肾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9482, encryptionId=c83e94827d, topicName=IgA肾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd7c3073380, createdName=huiwelcome, createdTime=Thu Feb 20 00:23:00 CST 2014, time=2014-02-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1503882, encodeId=48df1503882c5, content=<a href='/topic/show?id=641d94e7eb' target=_blank style='color:#2F92EE;'>#IgA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9477, encryptionId=641d94e7eb, topicName=IgA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c23f9697922, createdName=yibei, createdTime=Thu Feb 20 00:23:00 CST 2014, time=2014-02-20, status=1, ipAttribution=)]
    2014-02-20 yibei

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2型糖尿病患者,任何程度可测的尿蛋白排泄,即使是在被认为是正常范围内也会增加患者出现心脏问题的风险,据一项发表在Journal of the American Society of Nephrology (JASN)杂志上的最新研究证实,这一发现可能有助于确定哪些人应被视为需服用心脏保护药物的患者。 有些2型糖尿病患者会出现一些肾脏问题,导致他们的尿液白蛋白排泄量增加,这种情况称为蛋白尿。这些病