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JASN : 输尿管细胞的发展史

2017-06-26 许奕晗 MedSci原创

UreterCellLineages
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大家都知道，哺乳动物的输尿管是由平滑肌细胞构成的间质壁、周围成纤维细胞的外膜和固有层、基底和中间层组成的上皮内衬和表层细胞组成。但是这些细胞是如何从多能干细胞发育而来呢？关于这一点却知之甚少。但近日在Journal of the American Society of Nephrology上发表的研究文章却揭示了输尿管细胞谱的发展史。

大家都知道，哺乳动物的输尿管是由平滑肌细胞构成的间质壁、周围成纤维细胞的外膜和固有层、基底和中间层组成的上皮内衬和表层细胞组成。但是这些细胞是如何从多能干细胞发育而来呢？关于这一点却知之甚少。但近日在Journal of the American Society of Nephrology上发表的研究文章却揭示了输尿管细胞谱的发展史。

该研究进行了标记分析、细胞增殖试验，为了确认间质细胞和上皮细胞类型在发育和成熟的小鼠输尿管的谱系关系和限制，还进行了遗传谱系追踪试验。

在胚胎天（E）12.5，间质前体池开始细分为内室和外室，分别在E13.5开始分别表达平滑肌前体和血管外膜成纤维细胞的标记物。平滑肌前体进一步直接向固有层细胞分化，与输尿管上皮和从E16.5开始分化的平滑肌细胞相邻。在E14.5未分化的输尿管上皮细胞分化为中间细胞。在E15.5分为两层和E18.5分为三层后，中间细胞分化成基底细胞和表层细胞。在平衡状态中，所有上皮和间充质细胞类型的增值仍然很低，但中间细胞引起了基底细胞的增值，而基底细胞只分化为基底细胞。

这些研究为进一步确定细胞分化在发育的输尿管中的分子机制奠定了一个框架。

原始出处：
Prof. Andreas Kispert. et al.Diversification of Cell Lineages in Ureter Development
.J Am SOC NEPHROL.2017.

本文系梅斯医学（MedSci）原创编译整理，转载需授权！


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评论区 (3)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1941324, encodeId=3843194132409, content=<a href='/topic/show?id=bd2f28e0e1' target=_blank style='color:#2F92EE;'>#ASN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2870, encryptionId=bd2f28e0e1, topicName=ASN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1777154, createdName=chenhongpeng, createdTime=Fri Jan 12 02:25:00 CST 2018, time=2018-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640830, encodeId=5978164083045, content=<a href='/topic/show?id=6ead93e7366' target=_blank style='color:#2F92EE;'>#输尿管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93773, encryptionId=6ead93e7366, topicName=输尿管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d9f722746129, createdName=12498bb3m97(暂无昵称), createdTime=Wed May 16 16:25:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=215668, encodeId=a22b215668f1, content=学习了 学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbkwiamQRUZ02EtNQ6eQflk4CHafHibKTV9ju5ia6AkEvQuZagYnTGsFTuibpHDwZUicuFmVBsIZ0qbJg/0, createdBy=bc812071404, createdName=xuyihan, createdTime=Mon Jun 26 18:52:16 CST 2017, time=2017-06-26, status=1, ipAttribution=)]
    2018-01-12 chenhongpeng

    #ASN#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1941324, encodeId=3843194132409, content=<a href='/topic/show?id=bd2f28e0e1' target=_blank style='color:#2F92EE;'>#ASN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2870, encryptionId=bd2f28e0e1, topicName=ASN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1777154, createdName=chenhongpeng, createdTime=Fri Jan 12 02:25:00 CST 2018, time=2018-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640830, encodeId=5978164083045, content=<a href='/topic/show?id=6ead93e7366' target=_blank style='color:#2F92EE;'>#输尿管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93773, encryptionId=6ead93e7366, topicName=输尿管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d9f722746129, createdName=12498bb3m97(暂无昵称), createdTime=Wed May 16 16:25:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=215668, encodeId=a22b215668f1, content=学习了 学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbkwiamQRUZ02EtNQ6eQflk4CHafHibKTV9ju5ia6AkEvQuZagYnTGsFTuibpHDwZUicuFmVBsIZ0qbJg/0, createdBy=bc812071404, createdName=xuyihan, createdTime=Mon Jun 26 18:52:16 CST 2017, time=2017-06-26, status=1, ipAttribution=)]
    2018-05-16 12498bb3m97(暂无昵称)

    #输尿管#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1941324, encodeId=3843194132409, content=<a href='/topic/show?id=bd2f28e0e1' target=_blank style='color:#2F92EE;'>#ASN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2870, encryptionId=bd2f28e0e1, topicName=ASN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1777154, createdName=chenhongpeng, createdTime=Fri Jan 12 02:25:00 CST 2018, time=2018-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640830, encodeId=5978164083045, content=<a href='/topic/show?id=6ead93e7366' target=_blank style='color:#2F92EE;'>#输尿管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93773, encryptionId=6ead93e7366, topicName=输尿管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d9f722746129, createdName=12498bb3m97(暂无昵称), createdTime=Wed May 16 16:25:00 CST 2018, time=2018-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=215668, encodeId=a22b215668f1, content=学习了 学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbkwiamQRUZ02EtNQ6eQflk4CHafHibKTV9ju5ia6AkEvQuZagYnTGsFTuibpHDwZUicuFmVBsIZ0qbJg/0, createdBy=bc812071404, createdName=xuyihan, createdTime=Mon Jun 26 18:52:16 CST 2017, time=2017-06-26, status=1, ipAttribution=)]
    2017-06-26 xuyihan

    学习了 学习了

    0