Annals of Surgery:中性粒细胞/淋巴细胞比值预测IPMN相关侵袭癌

2016-09-27 MedSci MedSci原创

目的:评估中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞比值(PLR),和导管内乳头状黏液性肿瘤(IPMN)患者存在侵袭癌之间的关系。背景:NLR和PLR是与侵袭性恶性肿瘤(包括胰腺癌)患者的总生存率相关的炎症标志物。方法:我们对1997年1月到2015年7月,病例证实IPMN、进行手术切除的272例患者,进行了回顾性分析。计算了NLR和PLR,结合人口、临床和影像数据,对IPMN相关侵袭癌

目的:评估中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞比值(PLR),和导管内乳头状黏液性肿瘤(IPMN)患者存在侵袭癌之间的关系。

背景:NLR和PLR是与侵袭性恶性肿瘤(包括胰腺癌)患者的总生存率相关的炎症标志物。

方法:我们对1997年1月到2015年7月,病例证实IPMN、进行手术切除的272例患者,进行了回顾性分析。计算了NLR和PLR,结合人口、临床和影像数据,对IPMN相关侵袭癌的可能性进行评估。

结果:在IPMN相关侵袭癌患者中,NLR和PLR显著升高(P < 0.001)。多变量分析显示,NLR值大于4(P<0.001)、IPMN囊肿尺寸>3cm (P < 0.001)、影像学上可见增强的固体成分(P = 0.014)、主胰管扩张超过5 mm (P < 0.001)和黄疸(P<0.001)是具有统计学意义的变量。开发的预测统计模型其预测指数为0.895。在预测列线图中使用具有统计学意义的变量,可以预测是否存在IPMN相关侵袭癌。

结论:NLR是存在IPMN相关侵袭癌的独立预测指标。需要进一步的前瞻性研究来评估NLR的预测能力,以及如何将研究发现运用到临床上。

原始出处:

Gemenetzis, Georgios MD;et al.Neutrophil-to-lymphocyte Ratio is a Predictive Marker for Invasive Malignancy in Intraductal Papillary Mucinous Neoplasms of the Pancreas.Annals of Surgery: September 14, 2016

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    2017-08-01 huangdf
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    2017-09-04 chg121
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