Sci Rep:由钝性眼创伤引起的视网膜色素上皮细胞后遗症:发病、视觉效果及相关因素!

2017-11-04 cuiguizhong MedSci原创

韩国首尔汉阳大学医院眼科系的Ahn SJ 近日在Sci Rep杂志上发表了他们近期的一项工作,他们对由钝性眼创伤引起的视网膜色素上皮细胞后遗症的发病及相关因素进行了详细的研究。

韩国首尔汉阳大学医院眼科系的Ahn SJ 近日在Sci Rep杂志上发表了他们近期的一项工作,他们对由钝性眼创伤引起的视网膜色素上皮细胞后遗症的发病及相关因素进行了详细的研究。

眼睛的钝性眼部创伤也可能导致视力的丧失,但原因尚未完全阐明。在他们的钝性眼外伤患者中,他们遇到一例视网膜色素上皮(RPE)后遗症的病例,这个病例与永久性视力丧失相关,发生在钝性眼部创伤后。


他们对这例急性钝性眼创伤引起的129例视网膜异常的患者进行了多中心回顾性队列研究,调查了视网膜色素上皮(RPE)后遗症的发生率,并研究了与之相关的因素和视觉结果。他们发现,视网膜色素上皮(RPE)后遗症发生在创伤后1个月内的有29例(22.5%),这些后遗症患者呈现色素沉着过度的特征。光学相干断层扫描(OCT)显示,异常的视网膜色素上皮(RPE)的光感受器完全损失。最终的视觉结果表明,视力在有无视网膜色素上皮(RPE)后遗症患者之间存在着显著性的差异。Logistic回归分析显示,视网膜下部液体与RPE后遗症之间存在着显著的相关性。

总之,视网膜色素上皮(RPE)后遗症发生在钝性眼创伤患者中约占20%,并与永久性光感受器损伤和视力丧失有关。使用光学相干断层扫描(OCT)的临床诊断,有助于帮助患有钝性创伤的眼睛患者更好的预防患视网膜色素上皮(RPE)后遗症的风险。

 

原文出处:

Ahn, S.J., et al., Retinal Pigment Epithelium Sequelae Caused by Blunt Ocular Trauma: Incidence, Visual Outcome, and Associated Factors. Sci Rep, 2017. 7(1): p. 14184.

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createdBy=570f404, createdName=xlxchina, createdTime=Wed Mar 21 18:23:00 CST 2018, time=2018-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1810948, encodeId=2f7d181094854, content=<a href='/topic/show?id=bf4486e08be' target=_blank style='color:#2F92EE;'>#色素上皮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86708, encryptionId=bf4486e08be, topicName=色素上皮)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73a3403, createdName=weihongyv, createdTime=Sat Dec 23 09:23:00 CST 2017, time=2017-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1269967, encodeId=c071126996e3f, content=<a href='/topic/show?id=979690e33bd' target=_blank style='color:#2F92EE;'>#视网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90733, encryptionId=979690e33bd, topicName=视网膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Mon Nov 06 12:23:00 CST 2017, time=2017-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1335186, encodeId=7c7e13351864a, content=<a href='/topic/show?id=e7cc32022c7' target=_blank style='color:#2F92EE;'>#创伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32022, encryptionId=e7cc32022c7, topicName=创伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa5a2500103, createdName=ms920641618706883, createdTime=Mon Nov 06 12:23:00 CST 2017, time=2017-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1418782, encodeId=ced21418e829d, content=<a href='/topic/show?id=da8839121bb' target=_blank style='color:#2F92EE;'>#后遗症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39121, encryptionId=da8839121bb, topicName=后遗症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=615b3422729, createdName=huirong, createdTime=Mon Nov 06 12:23:00 CST 2017, time=2017-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1457476, encodeId=02f1145e476ab, content=<a href='/topic/show?id=4159e25296d' target=_blank style='color:#2F92EE;'>#相关因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72529, encryptionId=4159e25296d, topicName=相关因素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=19655942413, createdName=zzc2213, createdTime=Mon Nov 06 12:23:00 CST 2017, time=2017-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481087, encodeId=97b0148108ec8, content=<a href='/topic/show?id=c592908329c' target=_blank style='color:#2F92EE;'>#视觉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90832, encryptionId=c592908329c, topicName=视觉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=adcf7732830, createdName=zywlvao, createdTime=Mon Nov 06 12:23:00 CST 2017, time=2017-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1533839, encodeId=26cc153383935, content=<a href='/topic/show?id=4be9200308c' target=_blank style='color:#2F92EE;'>#上皮细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20030, encryptionId=4be9200308c, topicName=上皮细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a5d12492718, createdName=lizhou0208, createdTime=Mon Nov 06 12:23:00 CST 2017, time=2017-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1568412, encodeId=7dc6156841273, content=<a href='/topic/show?id=9fec9080901' target=_blank style='color:#2F92EE;'>#视网膜色素上皮细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90809, encryptionId=9fec9080901, topicName=视网膜色素上皮细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b1be15374853, createdName=wetgdt, createdTime=Mon Nov 06 12:23:00 CST 2017, time=2017-11-06, status=1, ipAttribution=)]
    2017-11-06 zutt
  5. [GetPortalCommentsPageByObjectIdResponse(id=1680463, encodeId=788a16804635b, content=<a href='/topic/show?id=9e5c86e0712' target=_blank style='color:#2F92EE;'>#色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86707, encryptionId=9e5c86e0712, topicName=色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=343027846633, createdName=sunylz, createdTime=Tue Dec 26 16:23:00 CST 2017, time=2017-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1810979, encodeId=6c8a18109e955, content=<a href='/topic/show?id=560e86e092b' target=_blank style='color:#2F92EE;'>#色素上皮细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86709, encryptionId=560e86e092b, topicName=色素上皮细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=570f404, createdName=xlxchina, createdTime=Wed Mar 21 18:23:00 CST 2018, time=2018-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1810948, encodeId=2f7d181094854, content=<a href='/topic/show?id=bf4486e08be' target=_blank style='color:#2F92EE;'>#色素上皮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86708, encryptionId=bf4486e08be, topicName=色素上皮)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73a3403, createdName=weihongyv, createdTime=Sat Dec 23 09:23:00 CST 2017, time=2017-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1269967, encodeId=c071126996e3f, content=<a href='/topic/show?id=979690e33bd' target=_blank style='color:#2F92EE;'>#视网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90733, encryptionId=979690e33bd, topicName=视网膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Mon Nov 06 12:23:00 CST 2017, time=2017-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1335186, encodeId=7c7e13351864a, content=<a href='/topic/show?id=e7cc32022c7' target=_blank style='color:#2F92EE;'>#创伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32022, encryptionId=e7cc32022c7, topicName=创伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa5a2500103, createdName=ms920641618706883, createdTime=Mon Nov 06 12:23:00 CST 2017, time=2017-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1418782, encodeId=ced21418e829d, content=<a href='/topic/show?id=da8839121bb' target=_blank style='color:#2F92EE;'>#后遗症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39121, encryptionId=da8839121bb, topicName=后遗症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=615b3422729, createdName=huirong, createdTime=Mon Nov 06 12:23:00 CST 2017, time=2017-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1457476, encodeId=02f1145e476ab, content=<a href='/topic/show?id=4159e25296d' target=_blank style='color:#2F92EE;'>#相关因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72529, encryptionId=4159e25296d, topicName=相关因素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=19655942413, createdName=zzc2213, createdTime=Mon Nov 06 12:23:00 CST 2017, time=2017-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481087, encodeId=97b0148108ec8, content=<a 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1568412, encodeId=7dc6156841273, content=<a href='/topic/show?id=9fec9080901' target=_blank style='color:#2F92EE;'>#视网膜色素上皮细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90809, encryptionId=9fec9080901, topicName=视网膜色素上皮细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b1be15374853, createdName=wetgdt, createdTime=Mon Nov 06 12:23:00 CST 2017, time=2017-11-06, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1680463, encodeId=788a16804635b, content=<a href='/topic/show?id=9e5c86e0712' target=_blank style='color:#2F92EE;'>#色素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86707, encryptionId=9e5c86e0712, topicName=色素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=343027846633, createdName=sunylz, createdTime=Tue Dec 26 16:23:00 CST 2017, time=2017-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1810979, encodeId=6c8a18109e955, content=<a href='/topic/show?id=560e86e092b' target=_blank style='color:#2F92EE;'>#色素上皮细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86709, encryptionId=560e86e092b, topicName=色素上皮细胞)], attachment=null, authenticateStatus=null, createdAvatar=, 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channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39121, encryptionId=da8839121bb, topicName=后遗症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=615b3422729, createdName=huirong, createdTime=Mon Nov 06 12:23:00 CST 2017, time=2017-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1457476, encodeId=02f1145e476ab, content=<a href='/topic/show?id=4159e25296d' target=_blank style='color:#2F92EE;'>#相关因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72529, encryptionId=4159e25296d, topicName=相关因素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=19655942413, createdName=zzc2213, createdTime=Mon Nov 06 12:23:00 CST 2017, time=2017-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481087, encodeId=97b0148108ec8, content=<a href='/topic/show?id=c592908329c' target=_blank style='color:#2F92EE;'>#视觉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90832, encryptionId=c592908329c, topicName=视觉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=adcf7732830, createdName=zywlvao, createdTime=Mon Nov 06 12:23:00 CST 2017, time=2017-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1533839, encodeId=26cc153383935, content=<a href='/topic/show?id=4be9200308c' target=_blank style='color:#2F92EE;'>#上皮细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20030, encryptionId=4be9200308c, topicName=上皮细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a5d12492718, createdName=lizhou0208, createdTime=Mon Nov 06 12:23:00 CST 2017, time=2017-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1568412, encodeId=7dc6156841273, content=<a href='/topic/show?id=9fec9080901' target=_blank style='color:#2F92EE;'>#视网膜色素上皮细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90809, encryptionId=9fec9080901, topicName=视网膜色素上皮细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b1be15374853, createdName=wetgdt, createdTime=Mon Nov 06 12:23:00 CST 2017, time=2017-11-06, status=1, ipAttribution=)]
    2017-11-06 huirong
  7. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1568412, encodeId=7dc6156841273, content=<a href='/topic/show?id=9fec9080901' target=_blank style='color:#2F92EE;'>#视网膜色素上皮细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90809, encryptionId=9fec9080901, topicName=视网膜色素上皮细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b1be15374853, createdName=wetgdt, createdTime=Mon Nov 06 12:23:00 CST 2017, time=2017-11-06, status=1, ipAttribution=)]
  8. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1568412, encodeId=7dc6156841273, content=<a href='/topic/show?id=9fec9080901' target=_blank style='color:#2F92EE;'>#视网膜色素上皮细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90809, encryptionId=9fec9080901, topicName=视网膜色素上皮细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b1be15374853, createdName=wetgdt, createdTime=Mon Nov 06 12:23:00 CST 2017, time=2017-11-06, status=1, ipAttribution=)]
    2017-11-06 zywlvao
  9. 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  10. 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