JAMA:舒张压较低与脑萎缩进展较快相关

2013-07-19 高晓方 译 JAMA

荷兰一项研究表明,在伴有动脉疾病表现的患者中,基线舒张压较低与脑皮质下萎缩进展较快具有相关性,并且与随访期间的血压进程无关。论文6月10日在线发表于《美国医学会 神经病学》杂志(JAMA Neurol)。 此项前瞻性研究共纳入663例伴有冠脉疾病、脑血管病、周围动脉病或腹主动脉瘤的患者(平均年龄57岁)。利用基线和随访时自动分段对脑实质分数、皮层灰质分数和脑室分数进行定量,以判断整体、

荷兰一项研究表明,在伴有动脉疾病表现的患者中,基线舒张压较低与脑皮质下萎缩进展较快具有相关性,并且与随访期间的血压进程无关。论文6月10日在线发表于《美国医学会 神经病学》杂志(JAMA Neurol)。

此项前瞻性研究共纳入663例伴有冠脉疾病、脑血管病、周围动脉病或腹主动脉瘤的患者(平均年龄57岁)。利用基线和随访时自动分段对脑实质分数、皮层灰质分数和脑室分数进行定量,以判断整体、皮质和皮质下脑萎缩进展。平均随访时间为3.9年。

结果显示,多变量校正回归分析表明,基线舒张压或平均动脉压较低的患者皮质下萎缩进展更显著。高、低舒张压患者的脑室分数变化平均差异为0.07%,高、低平均动脉压患者则为0.05%。此外,在基线血压(舒张压、平均动脉压或收缩压)较高的患者中,血压降低者随时间推移的皮质下萎缩进展轻于血压升高者。

原始出处:

Hadassa M. Jochemsen, MD; Majon Muller, MD, PhD; Frank L. Visseren, MD, PhD; Philip Scheltens, MD, PhD; Koen L. Vincken, PhD; Willem P. Mali, MD, PhD; Yolanda van der Graaf, MD, PhD; Mirjam I. Geerlings, PhD; for the SMART Study Group.Blood Pressure and Progression of Brain AtrophyThe SMART-MR Study,June 10, 2013.JAMA Neurol. 2013;():1-7. doi:10.1001/jamaneurol.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (3)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1695732, encodeId=61531695e32ad, content=<a href='/topic/show?id=03b98809697' target=_blank style='color:#2F92EE;'>#萎缩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88096, encryptionId=03b98809697, topicName=萎缩)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=53fc29868494, createdName=chendoc252, createdTime=Mon Mar 17 03:02:00 CST 2014, time=2014-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1323081, encodeId=59e613230819f, content=<a href='/topic/show?id=80ca865895e' target=_blank style='color:#2F92EE;'>#舒张压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86589, encryptionId=80ca865895e, topicName=舒张压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Sun Jul 21 05:02:00 CST 2013, time=2013-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401197, encodeId=6675140119e11, content=<a href='/topic/show?id=3405850e3f4' target=_blank style='color:#2F92EE;'>#脑萎缩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85073, encryptionId=3405850e3f4, topicName=脑萎缩)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/xdmCjlickSzn2cxg75bTZeYl2VYrTV6hibyMlic5XVFkibQbmFB7tK72afyxE4iclBhv7qd91qSk8Q6yicAcmErXRFxQ/132, createdBy=2c5d2304811, createdName=smartjoy, createdTime=Sun Jul 21 05:02:00 CST 2013, time=2013-07-21, status=1, ipAttribution=)]
    2014-03-17 chendoc252
  2. [GetPortalCommentsPageByObjectIdResponse(id=1695732, encodeId=61531695e32ad, content=<a href='/topic/show?id=03b98809697' target=_blank style='color:#2F92EE;'>#萎缩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88096, encryptionId=03b98809697, topicName=萎缩)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=53fc29868494, createdName=chendoc252, createdTime=Mon Mar 17 03:02:00 CST 2014, time=2014-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1323081, encodeId=59e613230819f, content=<a href='/topic/show?id=80ca865895e' target=_blank style='color:#2F92EE;'>#舒张压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86589, encryptionId=80ca865895e, topicName=舒张压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Sun Jul 21 05:02:00 CST 2013, time=2013-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401197, encodeId=6675140119e11, content=<a href='/topic/show?id=3405850e3f4' target=_blank style='color:#2F92EE;'>#脑萎缩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85073, encryptionId=3405850e3f4, topicName=脑萎缩)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/xdmCjlickSzn2cxg75bTZeYl2VYrTV6hibyMlic5XVFkibQbmFB7tK72afyxE4iclBhv7qd91qSk8Q6yicAcmErXRFxQ/132, createdBy=2c5d2304811, createdName=smartjoy, createdTime=Sun Jul 21 05:02:00 CST 2013, time=2013-07-21, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1695732, encodeId=61531695e32ad, content=<a href='/topic/show?id=03b98809697' target=_blank style='color:#2F92EE;'>#萎缩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88096, encryptionId=03b98809697, topicName=萎缩)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=53fc29868494, createdName=chendoc252, createdTime=Mon Mar 17 03:02:00 CST 2014, time=2014-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1323081, encodeId=59e613230819f, content=<a href='/topic/show?id=80ca865895e' target=_blank style='color:#2F92EE;'>#舒张压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86589, encryptionId=80ca865895e, topicName=舒张压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Sun Jul 21 05:02:00 CST 2013, time=2013-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401197, encodeId=6675140119e11, content=<a href='/topic/show?id=3405850e3f4' target=_blank style='color:#2F92EE;'>#脑萎缩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85073, encryptionId=3405850e3f4, topicName=脑萎缩)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/xdmCjlickSzn2cxg75bTZeYl2VYrTV6hibyMlic5XVFkibQbmFB7tK72afyxE4iclBhv7qd91qSk8Q6yicAcmErXRFxQ/132, createdBy=2c5d2304811, createdName=smartjoy, createdTime=Sun Jul 21 05:02:00 CST 2013, time=2013-07-21, status=1, ipAttribution=)]