PLoS One:关于临床上单侧剥脱综合征患者两个眼睛之间视网膜血管直径和青光眼参数的比较

2017-06-24 cuiguizhong MedSci原创

剥脱综合征(PEX)是开角型青光眼最常见的致病原因,并且可能会影响视网膜血流动力学。PE的沉积可引起视网膜小动脉和小静脉中的血管变窄。

近日,来自岛根大学医学教育部眼科系Ohira A教授及其团队在PLoS One上发表了他们的最近研究:关于临床上单侧剥脱综合征患者两个眼睛之间视网膜血管直径和青光眼参数的比较。

剥脱综合征(PEX)是开角型青光眼最常见的致病原因,并且可能会影响视网膜血流动力学。为了回答这一问题,作者们比较了临床上单侧剥脱综合征患者眼睛的视网膜血管直径和青光眼相关参数。

研究中对30个日本国民的医疗记录进行了回顾性分析。对他们的视网膜血管直径进行测定,并使用标准化软件处理中央视网膜动脉当量(CRAE)和视网膜中央小静脉当量(CRVE)。在统计数据中,作者们记录了青光眼相关参数,包括眼内压(IOP)、视野平均偏差(MD)值、垂直C / D比率、视网膜神经纤维层厚度(cpRNFLT )和谱域光学相干断层扫描测得的的内部视网膜黄斑厚度、前房耀斑(ACF)、角膜内皮细胞密度(CECD)和抗青光眼药物的数量。

与PE-眼睛相比,CRAE、CRVE、MD、cpRNFLT、MIRT和CECD在PE +眼睛中显着降低;而眼压,垂直C / D比率、抗青光眼药物的数量和ACF 在PE +眼睛中则显着升高(P <0.0001)。CRAE、cpRNFLT和MD彼此呈正相关关系(ρ= 0.456-0.499,P <0.0001-0.0002),但是和IOP呈负相关关系(ρ= -0.562-0432,P <0.0001-0.0006)。垂直C / D比率和IOP呈正相关关系(ρ= 0.483,P <0.0001),而和CRAE、cpRNFLT、MD呈负相关关系(ρ= -0745-0479,P <0.0001-0.0001)。

综合以上结果,作者们得出结论:PE的沉积可引起视网膜小动脉和小静脉中的血管变窄。青光眼引起视网膜血管变窄的原因和病理机制尚待阐明。

原文出处:


本文系梅斯医学(MedSci)原创编译整理,转载需授权!

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (3)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1789987, encodeId=bc691e8998783, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Sun Aug 20 01:22:00 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1269897, encodeId=5fc5126989e21, content=<a href='/topic/show?id=979690e33bd' target=_blank style='color:#2F92EE;'>#视网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90733, encryptionId=979690e33bd, topicName=视网膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Mon Jun 26 12:22:00 CST 2017, time=2017-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1430865, encodeId=bc6b1430865b4, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Jun 26 12:22:00 CST 2017, time=2017-06-26, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1789987, encodeId=bc691e8998783, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Sun Aug 20 01:22:00 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1269897, encodeId=5fc5126989e21, content=<a href='/topic/show?id=979690e33bd' target=_blank style='color:#2F92EE;'>#视网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90733, encryptionId=979690e33bd, topicName=视网膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Mon Jun 26 12:22:00 CST 2017, time=2017-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1430865, encodeId=bc6b1430865b4, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Jun 26 12:22:00 CST 2017, time=2017-06-26, status=1, ipAttribution=)]
    2017-06-26 zutt
  3. [GetPortalCommentsPageByObjectIdResponse(id=1789987, encodeId=bc691e8998783, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Sun Aug 20 01:22:00 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1269897, encodeId=5fc5126989e21, content=<a href='/topic/show?id=979690e33bd' target=_blank style='color:#2F92EE;'>#视网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90733, encryptionId=979690e33bd, topicName=视网膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Mon Jun 26 12:22:00 CST 2017, time=2017-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1430865, encodeId=bc6b1430865b4, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Jun 26 12:22:00 CST 2017, time=2017-06-26, status=1, ipAttribution=)]