Endocr Pract:住院期间高钠血症会增加死亡风险?

2016-09-21 Seven L 译 MedSci原创

老年住院患者中,伴有高钠血症与不伴高钠血症的患者相比,死亡率更高。 来自耶路撒冷Shaare Zedek医疗中心的Gabriel Munter博士和同事,对33名高钠血症(>70岁;入院时钠 > 150 meq/L)和30名非高钠血症的老年住院患者进行了研究。 收集参与者入院时的人口、功能和临床数据,以及血清和肽素水平(作为抗利尿激素分泌的标志物)。出院后随访30天。主要终点为死

老年住院患者中,伴有高钠血症与不伴高钠血症的患者相比,死亡率更高。

来自耶路撒冷Shaare Zedek医疗中心的Gabriel Munter博士和同事,对33名高钠血症(>70岁;入院时钠 > 150 meq/L)和30名非高钠血症的老年住院患者进行了研究。

收集参与者入院时的人口、功能和临床数据,以及血清和肽素水平(作为抗利尿激素分泌的标志物)。出院后随访30天。主要终点为死亡率和功能状态的改变。

入院时伴有高钠血症与不伴高钠血症的患者相比,基线功能和认知状态更低,白蛋白水平更低(P < .05),急性生理和慢性健康评估(APACHE)II评分更高(P < .01);入院到出院后30天内的死亡率更高(58% vs 32%; P < .05);和肽素水平更高(100.2 pmol/L vs. 66.5 pmol/L; P < .05)。

对所有患者进行评估,严重老年痴呆症患者有较高的和肽素水平。更高的死亡率与更高的和肽素水平有关。与出院且存活的患者相比,住院期间死亡和出院后30天内死亡的患者,有更高的和肽素水平(院内死亡:P < .05;出院后死亡:P < .01)。

研究人员写道:入院时的高钠血症可以作为老年住院患者高死亡率的预测因素,不过高钠血症与死亡率究竟是因果关系,还是高钠血症仅仅是高死亡率的标记物,目前仍不清楚。

与以往的研究相比,高钠血症患者往往有高的和肽素水平,并且和肽素水平和APACHE II评分之间具有强烈相关性。所以和肽素水平或许也可以作为老年患者疾病严重程度的标志物。

原始出处:

Liber M, et al. HYPERNATREMIA AND COPEPTIN LEVELS IN THE ELDERLY HOSPITALIZED PATIENT.Endocr Pract. 2016;doi:10.4158/EP161240.OR.

Hypernatremia increases mortality risk during hospitalization.Healio.eptember 20, 2016

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    2016-10-03 1e0ece0dm09(暂无匿称)

    学习了谢谢

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  2. [GetPortalCommentsPageByObjectIdResponse(id=139274, encodeId=ff271392e4aa, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K46ZAxBHmHsph32KkfsWGwmickB6RsCUD8KruE4vo5CpvXfdu16GBpp4ibh6WJu1o9iatP1LWKDmvmic/0, createdBy=be6f1940165, createdName=1e0ece0dm09(暂无匿称), createdTime=Mon Oct 03 00:23:11 CST 2016, time=2016-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=134658, encodeId=348f1346580a, content=有用的知识,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76f6105517, createdName=Jiangyh0406, createdTime=Sun Sep 25 03:49:00 CST 2016, time=2016-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=134087, encodeId=f9e413408e08, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cb571956164, createdName=187清风, createdTime=Sat Sep 24 08:06:00 CST 2016, time=2016-09-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1255590, encodeId=ae0a12555901f, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Fri Sep 23 06:09:00 CST 2016, time=2016-09-23, status=1, ipAttribution=)]
    2016-09-25 Jiangyh0406

    有用的知识,谢谢分享

    0

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    2016-09-24 187清风

    继续关注

    0

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