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Diabetes Care：瘦素替代治疗对胰岛素分泌或β-细胞功能无显著影响

2014-02-11 高晓方 译 医学论坛网

瘦素替代治疗胰岛素分泌β-细胞功能
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美国一项研究表明，在伴有脂肪代谢障碍的瘦素缺陷患者中，瘦素替代治疗未显著影响胰岛素分泌或β-细胞功能。论文于2月4日在线发表于《糖尿病护理》(Diabetes Care)。【原文下载】 此项前瞻性开放标签研究共纳入13例先天性或获得性脂营养不良患者。在基线和瘦素替代治疗16～20周后于口服糖耐量试验(OGTT)期间测定血糖和C-肽水平;利用C-肽重叠法计算胰岛素分泌率(ISR)。利用OG

美国一项研究表明，在伴有脂肪代谢障碍的瘦素缺陷患者中，瘦素替代治疗未显著影响胰岛素分泌或β-细胞功能。论文于2月4日在线发表于《糖尿病护理》(Diabetes Care)。【原文下载】

此项前瞻性开放标签研究共纳入13例先天性或获得性脂营养不良患者。在基线和瘦素替代治疗16～20周后于口服糖耐量试验(OGTT)期间测定血糖和C-肽水平;利用C-肽重叠法计算胰岛素分泌率(ISR)。利用OGTT数学模型计算β-细胞葡萄糖敏感性和率敏感性。

结果显示，瘦素治疗后甘油三酯、游离脂肪酸和糖化血红蛋白(A1C)均显著降低。脂营养不良患者空腹及葡萄糖刺激后ISR均较高。然而，瘦素治疗对空腹ISR、OGTT期间总胰岛素分泌、β-细胞葡萄糖敏感性、率敏感性或胰岛素清除均无显著影响。

原始出处：

Muniyappa R, Brown RJ, Mari A, Joseph J, Warren MA, Cochran EK, Skarulis MC, Gorden P.Effects of Leptin Replacement Therapy on Pancreatic β-Cell Function in Patients With Lipodystrophy.Diabetes Care. 2014 Feb 4. 【原文下载】

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    2014-08-25 gwc392

    #分泌#

    0

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    2014-03-18 智智灵药

    #BET#

    0

  3. 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    2014-06-01 木头人513

    #Diabetes#

    0

  4. 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    2014-04-27 wfang555

    #替代治疗#

    0

  5. 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    2014-04-18 ms9608593228839890

    #DIA#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1682168, encodeId=d0ab168216888, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Mon Aug 25 08:38:00 CST 2014, time=2014-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1759401, encodeId=18e51e59401c2, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Tue Mar 18 06:38:00 CST 2014, time=2014-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1901177, encodeId=953a19011e79b, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Sun Jun 01 01:38:00 CST 2014, time=2014-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1692821, encodeId=ebc6169282118, content=<a href='/topic/show?id=e6d86032ee8' target=_blank style='color:#2F92EE;'>#替代治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60327, encryptionId=e6d86032ee8, topicName=替代治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b79d29305168, createdName=wfang555, createdTime=Sun Apr 27 09:38:00 CST 2014, time=2014-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1636809, encodeId=0d031636809c4, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Fri Apr 18 08:38:00 CST 2014, time=2014-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1749464, encodeId=011b1e49464cb, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Fri Aug 15 03:38:00 CST 2014, time=2014-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1366608, encodeId=11f913666083d, content=<a href='/topic/show?id=5065e125368' target=_blank style='color:#2F92EE;'>#瘦素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71253, encryptionId=5065e125368, topicName=瘦素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6cc1239, createdName=sodoo, createdTime=Thu Feb 13 02:38:00 CST 2014, time=2014-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1393474, encodeId=86f013934e4cb, content=<a href='/topic/show?id=6162838e390' target=_blank style='color:#2F92EE;'>#胰岛素分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83873, encryptionId=6162838e390, topicName=胰岛素分泌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e3e72500135, createdName=jingyanzhu715_39486101, createdTime=Thu Feb 13 02:38:00 CST 2014, time=2014-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1586776, encodeId=3f721586e76f3, content=<a href='/topic/show?id=a6d1e7821de' target=_blank style='color:#2F92EE;'>#细胞功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77821, encryptionId=a6d1e7821de, topicName=细胞功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ec517387980, createdName=般若傻瓜, createdTime=Thu Feb 13 02:38:00 CST 2014, time=2014-02-13, status=1, ipAttribution=)]
    2014-08-15 baoya

    #胰岛#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1682168, encodeId=d0ab168216888, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Mon Aug 25 08:38:00 CST 2014, time=2014-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1759401, encodeId=18e51e59401c2, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Tue Mar 18 06:38:00 CST 2014, time=2014-03-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1901177, encodeId=953a19011e79b, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, encryptionId=c097591ed5, topicName=Diabetes)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Sun Jun 01 01:38:00 CST 2014, time=2014-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1692821, encodeId=ebc6169282118, content=<a href='/topic/show?id=e6d86032ee8' target=_blank style='color:#2F92EE;'>#替代治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60327, encryptionId=e6d86032ee8, topicName=替代治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b79d29305168, createdName=wfang555, createdTime=Sun Apr 27 09:38:00 CST 2014, time=2014-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1636809, encodeId=0d031636809c4, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Fri Apr 18 08:38:00 CST 2014, time=2014-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1749464, encodeId=011b1e49464cb, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Fri Aug 15 03:38:00 CST 2014, time=2014-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1366608, encodeId=11f913666083d, content=<a href='/topic/show?id=5065e125368' target=_blank style='color:#2F92EE;'>#瘦素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71253, encryptionId=5065e125368, topicName=瘦素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6cc1239, createdName=sodoo, createdTime=Thu Feb 13 02:38:00 CST 2014, time=2014-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1393474, encodeId=86f013934e4cb, content=<a href='/topic/show?id=6162838e390' target=_blank style='color:#2F92EE;'>#胰岛素分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83873, encryptionId=6162838e390, topicName=胰岛素分泌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e3e72500135, createdName=jingyanzhu715_39486101, createdTime=Thu Feb 13 02:38:00 CST 2014, time=2014-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1586776, encodeId=3f721586e76f3, content=<a href='/topic/show?id=a6d1e7821de' target=_blank style='color:#2F92EE;'>#细胞功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77821, encryptionId=a6d1e7821de, topicName=细胞功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2ec517387980, createdName=般若傻瓜, createdTime=Thu Feb 13 02:38:00 CST 2014, time=2014-02-13, status=1, ipAttribution=)]
    2014-02-13 sodoo

    #瘦素#

    0

  8. 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    2014-02-13 jingyanzhu715_39486101

    #胰岛素分泌#

    0

  9. 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    2014-02-13 般若傻瓜

    #细胞功能#

    0