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Neurology：MRS标志物可预测轻度认知损害进展

2013-07-10 高晓方 译 cmt

认知损害MRI
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美国一项研究表明，在认知正常老人中，MRI和磁共振质子波谱（MRS）定量标志物可预测轻度认知损害（MCI）和认知减退。论文于6月12日在线发表于《神经病学》（Neurology）。 此项研究共纳入1156例认知正常的老年受试者，并至少进行一次年度临床随访。通过MRS对扣带回前区、海马体积和白质高信号体积加以定量，并通过MRI评估脑梗塞。利用Cox比例风险回归评估MRI和MRS标志物对MC

美国一项研究表明，在认知正常老人中，MRI和磁共振质子波谱（MRS）定量标志物可预测轻度认知损害（MCI）和认知减退。论文于6月12日在线发表于《神经病学》（Neurology）。

此项研究共纳入1156例认知正常的老年受试者，并至少进行一次年度临床随访。通过MRS对扣带回前区、海马体积和白质高信号体积加以定量，并通过MRI评估脑梗塞。利用Cox比例风险回归评估MRI和MRS标志物对MCI进展风险的影响，并利用线性混合效应模型评估其对认知减退的影响。

结果显示，中位随访2.8年之后，214例受试者进展为MCI或痴呆（估计发病率每年6.1%）。在单变量模型中，海马体积、白质高信号体积和N-乙酰天冬氨酸/肌醇为MCI的显著预测因素。在多变量模型中，仅海马体积减小和N-乙酰天冬氨酸/肌醇为MCI的独立预测因素。MCI的MRI/MRS预测因素以及脑梗塞均与认知减退相关（P< 0.05）。


MRI and MRS predictors of mild cognitive impairment in a population-based sample  

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    2013-10-12 ms1343860338762272

    #轻度认知损害#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1813759, encodeId=45dc1813e5991, content=<a href='/topic/show?id=184793615e5' target=_blank style='color:#2F92EE;'>#轻度认知损害#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93615, encryptionId=184793615e5, topicName=轻度认知损害)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKQBvJI9WesEs5nl29JIJ7mAquShibzBHQmTeHHwZMDlIzc5qoQUhTJOpOwiaxYa9UcibrZviaM7dL7aQ/132, createdBy=35cb2500499, createdName=ms1343860338762272, createdTime=Sat Oct 12 13:57:00 CST 2013, time=2013-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1840767, encodeId=f1791840e678b, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Tue Apr 08 14:57:00 CST 2014, time=2014-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2054843, encodeId=3430205484325, content=<a href='/topic/show?id=250012241d8' target=_blank style='color:#2F92EE;'>#mRS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12241, encryptionId=250012241d8, topicName=mRS)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/7F67E3BE360D6DD1D0A62E3E71E23CB6/100, createdBy=9d8a2500148, createdName=ms8888626721583891, createdTime=Mon May 12 07:57:00 CST 2014, time=2014-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1999314, encodeId=75d1199931490, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Sat Aug 17 10:57:00 CST 2013, time=2013-08-17, status=1, ipAttribution=)]
    2014-04-08 hukaixun

    #标志物#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1813759, encodeId=45dc1813e5991, content=<a href='/topic/show?id=184793615e5' target=_blank style='color:#2F92EE;'>#轻度认知损害#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93615, encryptionId=184793615e5, topicName=轻度认知损害)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKQBvJI9WesEs5nl29JIJ7mAquShibzBHQmTeHHwZMDlIzc5qoQUhTJOpOwiaxYa9UcibrZviaM7dL7aQ/132, createdBy=35cb2500499, createdName=ms1343860338762272, createdTime=Sat Oct 12 13:57:00 CST 2013, time=2013-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1840767, encodeId=f1791840e678b, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Tue Apr 08 14:57:00 CST 2014, time=2014-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2054843, encodeId=3430205484325, content=<a href='/topic/show?id=250012241d8' target=_blank style='color:#2F92EE;'>#mRS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12241, encryptionId=250012241d8, topicName=mRS)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/7F67E3BE360D6DD1D0A62E3E71E23CB6/100, createdBy=9d8a2500148, createdName=ms8888626721583891, createdTime=Mon May 12 07:57:00 CST 2014, time=2014-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1999314, encodeId=75d1199931490, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Sat Aug 17 10:57:00 CST 2013, time=2013-08-17, status=1, ipAttribution=)]
    2014-05-12 ms8888626721583891

    #mRS#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1813759, encodeId=45dc1813e5991, content=<a href='/topic/show?id=184793615e5' target=_blank style='color:#2F92EE;'>#轻度认知损害#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93615, encryptionId=184793615e5, topicName=轻度认知损害)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKQBvJI9WesEs5nl29JIJ7mAquShibzBHQmTeHHwZMDlIzc5qoQUhTJOpOwiaxYa9UcibrZviaM7dL7aQ/132, createdBy=35cb2500499, createdName=ms1343860338762272, createdTime=Sat Oct 12 13:57:00 CST 2013, time=2013-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1840767, encodeId=f1791840e678b, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Tue Apr 08 14:57:00 CST 2014, time=2014-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2054843, encodeId=3430205484325, content=<a href='/topic/show?id=250012241d8' target=_blank style='color:#2F92EE;'>#mRS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12241, encryptionId=250012241d8, topicName=mRS)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/7F67E3BE360D6DD1D0A62E3E71E23CB6/100, createdBy=9d8a2500148, createdName=ms8888626721583891, createdTime=Mon May 12 07:57:00 CST 2014, time=2014-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1999314, encodeId=75d1199931490, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Sat Aug 17 10:57:00 CST 2013, time=2013-08-17, status=1, ipAttribution=)]
    2013-08-17 yinhl1978

    #Neurol#

    0