Heart:射血分数保留与降低的心力衰竭患者的预后和NT-proBNP

2020-03-19 MedSci原创 MedSci原创

我们评估了住院的急性失代偿性心力衰竭伴射血分数降低(HFpEF)与射血分数降低(HFrEF)的心力衰竭住院患者N端前B型钠尿肽(NT-proBNP)水平绝对和百分比改变的预后意义。

我们评估了住院的急性失代偿性心力衰竭伴射血分数降低(HFpEF)与射血分数降低(HFrEF)的心力衰竭住院患者N端前B型钠尿肽(NT-proBNP)水平绝对和百分比改变的预后意义。

 

左心室射血分数≥50%的患者归为HFpEF(n = 283),而左室射血分数<40%的患者归为HFrEF(n = 776)。通过多变量校正Cox回归分析,分别评估了HFpEF和HFrEF患者出院后6个月全因死亡率的NT-proBNP水平绝对值和百分比变化的预后价值。比较心力衰竭组之间的合并症。

 

结果显示,出院的NT-proBNP水平在HFpEF和HFrEF中的预测结果相似:NT-proBNP水平增加2.7个因素时,HFpEF的死亡率HR为2.14(95%CI 1.48-3.09),HFrEF的死亡率HR为1.96(95%CI 1.60-2.40)。与参考组中NT-proBNP水平降低> 60%的死亡率相比,NT-proBNP降低≤30%(HFpEF为HR 4.60,95%CI 1.47-14.40;HFrEF为HR 3.36,95%CI 1.93-5.85)和> 30%-60%(HR 3.28,95%CI 1.07-10.12和HR 1.79,95%CI 0.90.99-3.26),死亡率预测也同样可能。低(≤3000μpg/ mL)而非高(>3000μpg/ mL)NT-proBNP排放类别的HFpEF患者与预后相关合并症的发生率高于HFrEF患者。

 

总之,我们的研究强调了-在证明NT-proBNP水平在HFpEF中提供与HFrEF相同的相对风险信息之后-NT-proBNP水平较低的HFpEF患者合并症比HFrEF患者的合并症对预后的影响更大。

 

原始出处:

 

Khibar SalahSusan Stienen, et al., Prognosis and NT-proBNP in heart failure patients with preserved versus reduced ejection fraction. Heart. 2019 Aug; 105(15): 1182–1189. doi: 10.1136/heartjnl-2018-314173

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    2020-03-21 huiwelcome
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    2020-03-21 mjldent
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    2020-03-21 zhaojie88
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    2020-03-21 slcumt
  6. [GetPortalCommentsPageByObjectIdResponse(id=1746313, encodeId=2a491e463133d, content=<a href='/topic/show?id=699a46801f4' target=_blank style='color:#2F92EE;'>#射血分数保留#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46801, encryptionId=699a46801f4, topicName=射血分数保留)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c84e35706999, createdName=lixiao3338, createdTime=Sun Dec 20 14:45:07 CST 2020, time=2020-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1289337, encodeId=783f128933ef6, content=<a href='/topic/show?id=ede136018b' target=_blank style='color:#2F92EE;'>#BNP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3601, encryptionId=ede136018b, topicName=BNP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cd0d217, createdName=huiwelcome, createdTime=Sat Mar 21 09:45:07 CST 2020, time=2020-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1290359, encodeId=621912903595b, content=<a href='/topic/show?id=f6e513111bc' target=_blank style='color:#2F92EE;'>#NT-proBNP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13111, encryptionId=f6e513111bc, topicName=NT-proBNP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5662228, createdName=mjldent, createdTime=Sat Mar 21 09:45:07 CST 2020, time=2020-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357439, encodeId=a694135e43938, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Mar 21 09:45:07 CST 2020, time=2020-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563258, encodeId=de0a156325891, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Sat Mar 21 09:45:07 CST 2020, time=2020-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1602248, encodeId=22dd1602248da, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Sat Mar 21 09:45:07 CST 2020, time=2020-03-21, status=1, ipAttribution=)]
    2020-03-21 sunylz