PANCREATOLOGY:高脂血症在Covid-19相关的急性呼吸窘迫综合征患者中频繁发生

2021-04-08 MedSci原创 MedSci原创

新冠的罪魁祸首——冠状病毒病2019(Covid-19)是一种会引起呼吸系统急性呼吸窘迫症的冠状病毒2(SARS-CoV-2)。

      新冠的罪魁祸首——冠状病毒病2019(Covid-19)是一种会引起呼吸系统急性呼吸窘迫症的冠状病毒2(SARS-CoV-2)。它主要感染的部位是感染的主要部位是肺泡细胞,患者有5%的几率出现严重的急性呼吸窘迫综合征(ARDS),当出现此类症状时有71%的患者需要机械通气。但是,SARS-CoV-2也会影响其他器官,急性肾损伤,心肌炎和肝功能障碍是严重SARS-CoV-2感染的常见并发症。

      然而,到目前为止,尚未有研究评估SARS-CoV-2是否会影响胰腺并引起胰腺组织损伤。通过本项研究,研究人员旨在探究严重的SARS-CoV-2感染是否与急性胰腺炎有关,以及这些患者是否需要紧急治疗。

 

      研究人员前瞻性地收集了患有Covid-19并存在ARDS症状的患者的临床信息,并对该患者队列进行了急性胰腺炎体征的分析(例如脂肪酶活性是否高于上限值的3倍)。研究结果显示与Covid-19相关的ARDS的患者中有超过1/3的患者(12/38)的血清脂肪酶活性> 180 U / l,脂肪酶活性中位数为422 U / l(186-1127)。在影像学研究中,没有患者显示出急性胰腺炎的典型发现。肠胃炎或肾功能不全不能解释血脂血症的发生,它发生在病毒清除之前和之后以及首次出现症状后的16.1±6.0天。在35.8±8.3天的随访期内,没有患者出现严重的急性胰腺炎的发生。

图:新冠患者血脂变化水平

 

      通过本项研究证实没有典型的急性胰腺炎迹象的高血脂血症是Covid-19相关的ARDS的患者常见的并发症之一。应该要重视新冠肺炎患者血脂水平的监测。

 

 

原始出处:

Sebastian Rasch. Et al. High lipasemia is frequent in Covid-19 associated acute respiratory distress syndrome. Pancreatology.2021.

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    2022-05-26 屋顶瞄爱赏月

    签到学习

    0

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    2022-04-26 病毒猎手

    #高脂血症##Covid-19#相关的急性呼吸窘迫综合征患者中频繁发生

    0

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time=2021-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=955293, encodeId=d60a95529319, content=了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Thu Apr 08 20:44:01 CST 2021, time=2021-04-08, status=1, ipAttribution=)]
    2021-09-19 病毒猎手

    #急性呼吸窘迫综合征##ARDS#,这个研究值得思考

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1222550, encodeId=defd1222550f3, content=签到学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211111/81c0b64745c644319545ec26d7ef0b34/9ddb2864d5df4dd9bf4305e380bffc96.jpg, createdBy=c7835705079, createdName=屋顶瞄爱赏月, createdTime=Thu May 26 10:26:18 CST 2022, time=2022-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1214476, encodeId=d3e412144e66f, content=<a href='/topic/show?id=fc78102625d7' target=_blank style='color:#2F92EE;'>#高脂血症#</a>在<a href='/topic/show?id=f52851329b' target=_blank style='color:#2F92EE;'>#Covid-19#</a>相关的急性呼吸窘迫综合征患者中频繁发生, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102625, encryptionId=fc78102625d7, topicName=高脂血症), 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createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Sun Sep 19 18:46:07 CST 2021, time=2021-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=960762, encodeId=01d1960e6203, content=这个切入点还是很有意思的, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3c0a5411271, createdName=ms6000000263565386, createdTime=Mon Apr 26 22:03:45 CST 2021, time=2021-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1432037, encodeId=f4a4143203e2b, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, 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href='/topic/show?id=2bc1519579' target=_blank style='color:#2F92EE;'>#CRE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5195, encryptionId=2bc1519579, topicName=CRE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4ca216802819, createdName=HinsMax, createdTime=Sat Apr 10 11:13:37 CST 2021, time=2021-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1582283, encodeId=61ad1582283a5, content=<a href='/topic/show?id=e46f396832b' target=_blank style='color:#2F92EE;'>#呼吸窘迫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39683, encryptionId=e46f396832b, topicName=呼吸窘迫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=22be16898890, createdName=12498cf9m40(暂无昵称), createdTime=Sat Apr 10 11:13:37 CST 2021, time=2021-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=955293, encodeId=d60a95529319, content=了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Thu Apr 08 20:44:01 CST 2021, time=2021-04-08, status=1, ipAttribution=)]
    2021-04-26 ms6000000263565386

    这个切入点还是很有意思的

    0

  5. 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  6. 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time=2021-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=955293, encodeId=d60a95529319, content=了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Thu Apr 08 20:44:01 CST 2021, time=2021-04-08, status=1, ipAttribution=)]
    2021-04-10 pcw111
  7. 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href='/topic/show?id=2bc1519579' target=_blank style='color:#2F92EE;'>#CRE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5195, encryptionId=2bc1519579, topicName=CRE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4ca216802819, createdName=HinsMax, createdTime=Sat Apr 10 11:13:37 CST 2021, time=2021-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1582283, encodeId=61ad1582283a5, content=<a href='/topic/show?id=e46f396832b' target=_blank style='color:#2F92EE;'>#呼吸窘迫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39683, encryptionId=e46f396832b, topicName=呼吸窘迫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=22be16898890, createdName=12498cf9m40(暂无昵称), createdTime=Sat Apr 10 11:13:37 CST 2021, time=2021-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=955293, encodeId=d60a95529319, content=了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Thu Apr 08 20:44:01 CST 2021, time=2021-04-08, status=1, ipAttribution=)]
    2021-04-10 HinsMax
  8. [GetPortalCommentsPageByObjectIdResponse(id=1222550, encodeId=defd1222550f3, content=签到学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211111/81c0b64745c644319545ec26d7ef0b34/9ddb2864d5df4dd9bf4305e380bffc96.jpg, createdBy=c7835705079, createdName=屋顶瞄爱赏月, createdTime=Thu May 26 10:26:18 CST 2022, time=2022-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1214476, encodeId=d3e412144e66f, content=<a href='/topic/show?id=fc78102625d7' target=_blank style='color:#2F92EE;'>#高脂血症#</a>在<a href='/topic/show?id=f52851329b' target=_blank style='color:#2F92EE;'>#Covid-19#</a>相关的急性呼吸窘迫综合征患者中频繁发生, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102625, encryptionId=fc78102625d7, topicName=高脂血症), TopicDto(id=5132, encryptionId=f52851329b, topicName=Covid-19)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Tue Apr 26 13:25:50 CST 2022, time=2022-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1053067, encodeId=77ef105306e7b, content=<a href='/topic/show?id=c7bc52238cf' target=_blank style='color:#2F92EE;'>#急性呼吸窘迫综合征#</a><a href='/topic/show?id=b0082e3590' target=_blank style='color:#2F92EE;'>#ARDS#</a>,这个研究值得思考, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52238, encryptionId=c7bc52238cf, topicName=急性呼吸窘迫综合征), TopicDto(id=2735, encryptionId=b0082e3590, topicName=ARDS)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=病毒猎手, createdTime=Sun Sep 19 18:46:07 CST 2021, time=2021-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=960762, encodeId=01d1960e6203, content=这个切入点还是很有意思的, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3c0a5411271, createdName=ms6000000263565386, createdTime=Mon Apr 26 22:03:45 CST 2021, time=2021-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1432037, encodeId=f4a4143203e2b, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, 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href='/topic/show?id=2bc1519579' target=_blank style='color:#2F92EE;'>#CRE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5195, encryptionId=2bc1519579, topicName=CRE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4ca216802819, createdName=HinsMax, createdTime=Sat Apr 10 11:13:37 CST 2021, time=2021-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1582283, encodeId=61ad1582283a5, content=<a href='/topic/show?id=e46f396832b' target=_blank style='color:#2F92EE;'>#呼吸窘迫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39683, encryptionId=e46f396832b, topicName=呼吸窘迫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=22be16898890, createdName=12498cf9m40(暂无昵称), createdTime=Sat Apr 10 11:13:37 CST 2021, time=2021-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=955293, encodeId=d60a95529319, content=了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Thu Apr 08 20:44:01 CST 2021, time=2021-04-08, status=1, ipAttribution=)]
  9. 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time=2021-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=955293, encodeId=d60a95529319, content=了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Thu Apr 08 20:44:01 CST 2021, time=2021-04-08, status=1, ipAttribution=)]
    2021-04-08 wxl882001

    了解

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