Clin Gastroenterol Hepatol：大肠癌筛查的新血液生物标志物

2014-10-28 佚名生物谷

在搜寻可以用于筛查大肠癌（CRC）的血源性生物标志物过程中，研究人员发现两个有前途的候选标志物有望用于开发新的血液测试。科学家们一直在探究参与CRC发展的分子机制，并且已确定异常的DNA甲基化模式和microRNAs的存在是大肠癌发生发展过程的主要参与者。在22nd United European Gastroenterology Week (UEG Week 2014)上，西班牙巴塞罗那消

在搜寻可以用于筛查大肠癌（CRC）的血源性生物标志物过程中，研究人员发现两个有前途的候选标志物有望用于开发新的血液测试。

科学家们一直在探究参与CRC发展的分子机制，并且已确定异常的DNA甲基化模式和microRNAs的存在是大肠癌发生发展过程的主要参与者。在22nd United European Gastroenterology Week (UEG Week 2014)上，西班牙巴塞罗那消化病医院临床研究所Antoni Castells博士说：我们现在能更好地了解参加CRC发展的分子事件，并且新的研究发现提供了有价值的靶标，其可以用于大肠癌的早期发现和新疗法的开发。

大肠癌是世界第三大常见癌症，在西方世界，是癌症相关死亡的第二大原因。在欧洲，参与大肠癌筛查项目的人数低得令人担心，Castells博士说：但一个简单的血液测试将鼓励更多的人挺身而出进行筛选，有可能每年挽救成千上万人的生命。

癌症生物标志物通常涉及到DNA、RNA或蛋白质表达改变，虽然有一些蛋白质生物标志物已被确定，然而，没有合适的标志物用于CRC筛查。直到最近，研究人员调查了CRC病人血液DNA，观察到异常的DNA甲基化模式，特别是DNA SEPT9异常甲基化，提示基于DNA的生物标志物是潜在的新筛查标志物。

由Castells博士列出的第二个潜在筛查方法包括评估microRNAs，microRNAs已被证明在CRC患者血浆中增加，由博士及其同事进行最近的一项研究中，他们发现CRC或晚期腺瘤患者的microRNA表达模式显著不同于健康人，研究小组得出结论：血浆microRNA的检测是CRC一种很有前途的筛选试验，值得进一步研究。

在这项初步研究中，大肠癌筛查的这两个潜在新标志物已经显示出潜力，应该在更大的患者群体中进一步探讨。

原始出处

Giráldez MD1, Lozano JJ, Ramírez G, Hijona E, Bujanda L, Castells A, Gironella M.Circulating microRNAs as biomarkers of colorectal cancer: results from a genome-wide profiling and validation study.Clin Gastroenterol Hepatol. 2013 Jun

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2015-09-28 jktdtl

#Gastroenterol#

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2015-06-09 ms24272190615788285182

#AST#

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2015-08-08 许安

#GAS#

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2015-06-12 hukaixun

#标志物#

30 0
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2014-10-30 智智灵药

#EPA#

21 0
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2014-10-30 zhu_jun9842

#生物标志#

18 0
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2014-10-30 zhu_jun9842

#生物标志#

24 0

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