Invest Radiol:高分辨磁共振神经成像在诊断臂丛神经损伤的价值

2017-08-31 shaosai MedSci原创

臂丛神经损伤(brachial plexus,BP)是周围神经损伤的一个常见类型,对臂从损伤(brachial plexus injury)的认识,最早是1768年Smeillie首次描述的1例臂丛产瘫麻痹。此后Ducheme(1861)、Erb(1874)描述了上干型产瘫,Klumpke(1885)描述了下干型产瘫。1874年Flaubert首次报道成人外伤性臂丛损伤,1886年Thorburn

臂丛神经损伤(brachial plexus,BP)是周围神经损伤的一个常见类型,对臂从损伤(brachial plexus injury)的认识,最早是1768年Smeillie首次描述的1例臂丛产瘫麻痹。此后Ducheme(1861)、Erb(1874)描述了上干型产瘫,Klumpke(1885)描述了下干型产瘫。1874年Flaubert首次报道成人外伤性臂丛损伤,1886年Thorburn首次进行了臂丛损伤手术修复。但直至1966年SICOT巴黎会议,臂丛损伤修复的疗效一直令人失望。随着臂丛显微外科修复技术尤其是神经移位术的开展,臂丛损伤的疗效逐步提高,这一领域我国顾玉东、瑞士Narakas等做出了重大贡献。本研究旨在评价高分辨臂丛(BP)磁共振神经成像(MRN)在(1)检出压迫性神经病变和非压迫性神经病变的价值,(2)鉴别压迫性神经病变和非压迫性神经病变的价值和(3)发现臂丛神经筋膜损伤的价值,并将结果发表在Invest Radiol上。

本研究共纳入了36例临床症状、神经传导检查和肌电图诊断臂丛神经损伤的患者和36例年龄和性别相匹配的健康志愿者,并行BP高分辨MRN。由两名神经放射学医师独立地在BP神经干、束水平评价病变的性质和位置。

通过在高分辨MRN图像上定义臂丛病变的标准,经两位神经放射学医生独立并采用盲法分析,所有患者发现受累臂丛病变,然而有34/36健康志愿者诊断为正常臂丛神经结构,两观察者间一致性良好。在所有病例中,压迫性BP病变(n = 12)准确地从非压迫性炎性臂丛病变(n = 24)中鉴别出来。根据病变从干延续到束水平的病理解剖学上的连续性可以区分出不同躯体定位的神经病变,后者与临床症状和电生理检查结果密切相关。

本研究结果为,臂丛神经MRN能够准确地鉴别症状性神经丛病变和健康志愿者,并且能够鉴别压迫性和非压迫性神经丛病变。另外,BP MRN对BP躯体定位组构具有指导意义。因此,作为电生理检查结果和解剖信息之外的功能性信息,BP MRN有助于患者诊疗的有效性和准确性。

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    2017-10-31 lsndxfj
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