BMC Musculoskelet Disord:新型的 "双股骨 "腓骨踝关节置换术治疗胫骨远端肿瘤相关的大骨缺损

2020-04-23 MedSci原创 MedSci原创

胫骨远端肿瘤广泛切除后的大骨性缺损的重建是困难的,最佳方案仍有争议。本研究针对这一问题,提出了一种新颖的 "双股骨 "腓骨踝关节置换术。

胫骨远端肿瘤广泛切除后的大骨性缺损的重建是困难的,最佳方案仍有争议。本研究针对这一问题,提出了一种新颖的 "双股骨 "腓骨踝关节置换术。

 

对9例胫骨远端恶性或侵袭性肿瘤的患者进行了新型 "双股骨 "腓骨踝关节宽大肿瘤切除术后的 "双股骨 "关节置换术进行了回顾性研究。我们从临床和影像学角度评估了骨结合时间、并发症和肿瘤结局。肌肉骨骼肿瘤协会(MSTS)评分和足部和踝关节结果评分(FAOS)用于评估功能结局。

 

平均随访时间为53±46个月。在该系列中未观察到深层感染或移植物骨折。一例发现内固定松动。在这些患者中,有八名在近端和远端交界处实现了愈合,而一名仅在远端实现了愈合。近端和远端的平均结合时间分别为10.5±1.6月和8.7±2.3月。术后平均MSTS评分为83%±8%。 FAOS量表显示最大的问题是运动和娱乐功能,平均评分为18±11,在最后一次随访中,其中一个(1/9,11%)出现软组织局部复发并再次切除手术,四名(4/9,44%)患者发生了肺转移。

 

综上所述,该研究结果表明,对于胫骨远端大的骨性缺损,这种新型的 "双股骨 "腓骨重建术是一种可行的选择,能够实现持久的踝关节融合和功能救治肢体,并发症率低。

 

原始出处:

 

Zhiqing ZhaoTaiqiang Yan, et al., Novel “double-strut” fibula ankle arthrodesis for large tumor-related bone defect of distal tibia. BMC Musculoskelet Disord. 2019; 20: 367. doi: 10.1186/s12891-019-2742-6

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createdBy=050736663344, createdName=apoenzyme, createdTime=Sat Jul 25 19:26:19 CST 2020, time=2020-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1975018, encodeId=7c2d19e5018c1, content=<a href='/topic/show?id=f145355379' target=_blank style='color:#2F92EE;'>#BMC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3553, encryptionId=f145355379, topicName=BMC)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Tue Mar 09 10:26:19 CST 2021, time=2021-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1784422, encodeId=4ca31e84422a1, content=<a href='/topic/show?id=a727600194' target=_blank style='color:#2F92EE;'>#Disord#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6001, encryptionId=a727600194, topicName=Disord)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aad0444, createdName=cmsvly, createdTime=Tue Sep 29 22:26:19 CST 2020, time=2020-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1742702, encodeId=3a451e42702dc, content=<a href='/topic/show?id=39cae96626f' target=_blank style='color:#2F92EE;'>#置换#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79662, encryptionId=39cae96626f, topicName=置换)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3a7c35056336, createdName=yxch48, createdTime=Sat Oct 10 15:26:19 CST 2020, time=2020-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1412181, encodeId=476b141218147, content=<a href='/topic/show?id=504a83820a0' target=_blank style='color:#2F92EE;'>#胫骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83820, encryptionId=504a83820a0, topicName=胫骨)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5c442828835, createdName=yb6561, createdTime=Sat Apr 25 08:26:19 CST 2020, time=2020-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419342, encodeId=ead4141934212, content=<a href='/topic/show?id=2e2e10182602' target=_blank style='color:#2F92EE;'>#骨缺损#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101826, encryptionId=2e2e10182602, topicName=骨缺损)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=51173492599, createdName=lfcmxl, createdTime=Sat Apr 25 08:26:19 CST 2020, time=2020-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1464017, encodeId=9162146401ed8, content=<a href='/topic/show?id=87b99316273' target=_blank style='color:#2F92EE;'>#踝关节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93162, encryptionId=87b99316273, topicName=踝关节)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21ff6562509, createdName=qilu_qi, createdTime=Sat Apr 25 08:26:19 CST 2020, time=2020-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1529743, encodeId=8c831529e4324, content=<a href='/topic/show?id=70ff81e9156' target=_blank style='color:#2F92EE;'>#股骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81791, encryptionId=70ff81e9156, topicName=股骨)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9d3011964327, createdName=wangyang7962, createdTime=Sat Apr 25 08:26:19 CST 2020, time=2020-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1576771, encodeId=92d915e677127, content=<a href='/topic/show?id=48fee966468' target=_blank style='color:#2F92EE;'>#置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79664, encryptionId=48fee966468, topicName=置换术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=054816326830, createdName=ms117281293605716, createdTime=Sat Apr 25 08:26:19 CST 2020, time=2020-04-25, status=1, ipAttribution=)]
    2020-09-29 cmsvly
  5. [GetPortalCommentsPageByObjectIdResponse(id=2013317, encodeId=cca1201331ea8, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sun Dec 20 09:26:19 CST 2020, time=2020-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1754220, encodeId=00ff1e542204f, content=<a href='/topic/show?id=7d3330135ac' target=_blank style='color:#2F92EE;'>#关节置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30135, encryptionId=7d3330135ac, topicName=关节置换术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=050736663344, createdName=apoenzyme, createdTime=Sat Jul 25 19:26:19 CST 2020, time=2020-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1975018, encodeId=7c2d19e5018c1, content=<a href='/topic/show?id=f145355379' target=_blank style='color:#2F92EE;'>#BMC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3553, encryptionId=f145355379, topicName=BMC)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Tue Mar 09 10:26:19 CST 2021, time=2021-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1784422, encodeId=4ca31e84422a1, content=<a href='/topic/show?id=a727600194' target=_blank style='color:#2F92EE;'>#Disord#</a>, beContent=null, objectType=article, channel=null, 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href='/topic/show?id=504a83820a0' target=_blank style='color:#2F92EE;'>#胫骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83820, encryptionId=504a83820a0, topicName=胫骨)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5c442828835, createdName=yb6561, createdTime=Sat Apr 25 08:26:19 CST 2020, time=2020-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419342, encodeId=ead4141934212, content=<a href='/topic/show?id=2e2e10182602' target=_blank style='color:#2F92EE;'>#骨缺损#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101826, encryptionId=2e2e10182602, topicName=骨缺损)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=51173492599, createdName=lfcmxl, createdTime=Sat Apr 25 08:26:19 CST 2020, time=2020-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1464017, encodeId=9162146401ed8, content=<a href='/topic/show?id=87b99316273' target=_blank style='color:#2F92EE;'>#踝关节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93162, encryptionId=87b99316273, topicName=踝关节)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21ff6562509, createdName=qilu_qi, createdTime=Sat Apr 25 08:26:19 CST 2020, time=2020-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1529743, encodeId=8c831529e4324, content=<a href='/topic/show?id=70ff81e9156' target=_blank style='color:#2F92EE;'>#股骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81791, encryptionId=70ff81e9156, topicName=股骨)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9d3011964327, createdName=wangyang7962, createdTime=Sat Apr 25 08:26:19 CST 2020, time=2020-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1576771, encodeId=92d915e677127, content=<a href='/topic/show?id=48fee966468' target=_blank style='color:#2F92EE;'>#置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79664, encryptionId=48fee966468, topicName=置换术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=054816326830, createdName=ms117281293605716, createdTime=Sat Apr 25 08:26:19 CST 2020, time=2020-04-25, status=1, ipAttribution=)]
    2020-10-10 yxch48
  6. [GetPortalCommentsPageByObjectIdResponse(id=2013317, encodeId=cca1201331ea8, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sun Dec 20 09:26:19 CST 2020, time=2020-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1754220, encodeId=00ff1e542204f, content=<a href='/topic/show?id=7d3330135ac' target=_blank style='color:#2F92EE;'>#关节置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30135, encryptionId=7d3330135ac, topicName=关节置换术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=050736663344, createdName=apoenzyme, createdTime=Sat Jul 25 19:26:19 CST 2020, time=2020-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1975018, encodeId=7c2d19e5018c1, content=<a href='/topic/show?id=f145355379' target=_blank style='color:#2F92EE;'>#BMC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3553, encryptionId=f145355379, topicName=BMC)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Tue Mar 09 10:26:19 CST 2021, time=2021-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1784422, encodeId=4ca31e84422a1, content=<a href='/topic/show?id=a727600194' target=_blank style='color:#2F92EE;'>#Disord#</a>, beContent=null, objectType=article, channel=null, 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href='/topic/show?id=504a83820a0' target=_blank style='color:#2F92EE;'>#胫骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83820, encryptionId=504a83820a0, topicName=胫骨)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5c442828835, createdName=yb6561, createdTime=Sat Apr 25 08:26:19 CST 2020, time=2020-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419342, encodeId=ead4141934212, content=<a href='/topic/show?id=2e2e10182602' target=_blank style='color:#2F92EE;'>#骨缺损#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101826, encryptionId=2e2e10182602, topicName=骨缺损)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=51173492599, createdName=lfcmxl, createdTime=Sat Apr 25 08:26:19 CST 2020, time=2020-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1464017, encodeId=9162146401ed8, content=<a href='/topic/show?id=87b99316273' target=_blank style='color:#2F92EE;'>#踝关节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93162, encryptionId=87b99316273, topicName=踝关节)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21ff6562509, createdName=qilu_qi, createdTime=Sat Apr 25 08:26:19 CST 2020, time=2020-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1529743, encodeId=8c831529e4324, content=<a href='/topic/show?id=70ff81e9156' target=_blank style='color:#2F92EE;'>#股骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81791, encryptionId=70ff81e9156, topicName=股骨)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9d3011964327, createdName=wangyang7962, createdTime=Sat Apr 25 08:26:19 CST 2020, time=2020-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1576771, encodeId=92d915e677127, content=<a href='/topic/show?id=48fee966468' target=_blank style='color:#2F92EE;'>#置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79664, encryptionId=48fee966468, topicName=置换术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=054816326830, createdName=ms117281293605716, createdTime=Sat Apr 25 08:26:19 CST 2020, time=2020-04-25, status=1, ipAttribution=)]
    2020-04-25 yb6561
  7. [GetPortalCommentsPageByObjectIdResponse(id=2013317, encodeId=cca1201331ea8, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sun Dec 20 09:26:19 CST 2020, time=2020-12-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1754220, encodeId=00ff1e542204f, content=<a href='/topic/show?id=7d3330135ac' target=_blank style='color:#2F92EE;'>#关节置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30135, encryptionId=7d3330135ac, topicName=关节置换术)], attachment=null, authenticateStatus=null, createdAvatar=null, 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1464017, encodeId=9162146401ed8, content=<a href='/topic/show?id=87b99316273' target=_blank style='color:#2F92EE;'>#踝关节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93162, encryptionId=87b99316273, topicName=踝关节)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21ff6562509, createdName=qilu_qi, createdTime=Sat Apr 25 08:26:19 CST 2020, time=2020-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1529743, encodeId=8c831529e4324, content=<a href='/topic/show?id=70ff81e9156' target=_blank style='color:#2F92EE;'>#股骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81791, encryptionId=70ff81e9156, topicName=股骨)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9d3011964327, createdName=wangyang7962, createdTime=Sat Apr 25 08:26:19 CST 2020, time=2020-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1576771, encodeId=92d915e677127, content=<a href='/topic/show?id=48fee966468' target=_blank style='color:#2F92EE;'>#置换术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79664, encryptionId=48fee966468, topicName=置换术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=054816326830, createdName=ms117281293605716, createdTime=Sat Apr 25 08:26:19 CST 2020, time=2020-04-25, status=1, ipAttribution=)]
    2020-04-25 lfcmxl
  8. 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    2020-04-25 qilu_qi
  9. 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在牙周治疗中,根分叉缺损仍然是一个具有挑战性的课题。骨碎补(Dryfaria fortunei,Df)是骨科和创伤学领域中常见的中草药。体外和组织工程研究表明,Df诱导成骨细胞增殖并促进人牙周膜细胞的分化。本研究使用引导组织再生(GTR)和与β-磷酸三钙(β-TCP)同种异体混合的Df颗粒研究犬II类根分叉缺损的处理。

J Clin Periodontol:微创非手术治疗骨内缺损的长期稳定性

本研究旨在评估微创非手术治疗(MINST)和支持性牙周治疗(SPT)两种方法治疗牙周骨内缺损随时间的稳定性。

Biomed Pharmacother:血管生成素2促进组织工程骨中的血管生成,并通过诱导自噬改善骨缺损的修复

血管生成在组织工程骨修复大节段性骨缺损中起关键作用。然而,目前还未有有效的方法促进组织工程骨中的血管生成。研究已经证实血管生成素2(Ang2)和自噬均与血管生成有关,但其在组织工程骨的血管生成中的作用仍然未知。 体内研究中,使用新西兰白兔制造桡骨缺损,植入羟基磷灰石/胶原支架然后注射不同浓度的Ang2来治疗。通过蛋白质印迹法测量自噬调节剂微管相关蛋白1轻链3(LC3),Beclin-1和SQ