Int Forum Allergy Rhinol:在过敏性鼻炎中,鼻通气功能是评估鼻一氧化氮诊断价值的重要因素

2018-01-31 AlexYang MedSci原创

鼻一氧化氮(NO)在过敏性鼻炎(AR)诊断中的作用是具有争议的。最近,有研究人员在AR病人中,鉴定了能够影响鼻NO水平的因素,并且评估了鼻NO在AR诊断中的作用。研究包括了75名AR病人和31名健康对照。研究发现,鼻阻塞得分、嗜酸细胞阳离子蛋白(ECP)和鼻气道阻力(NAR)与鼻NO独立相关。鼻NO在鼻阻塞得分小于7(轻度到中度阻塞)的患者中的水平与对照相比,具有显著的增加(282.1 ± 122

鼻一氧化氮(NO)在过敏性鼻炎(AR)诊断中的作用是具有争议的。最近,有研究人员在AR病人中,鉴定了能够影响鼻NO水平的因素,并且评估了鼻NO在AR诊断中的作用。研究包括了75名AR病人和31名健康对照。

研究发现,鼻阻塞得分、嗜酸细胞阳离子蛋白(ECP)和鼻气道阻力(NAR)与鼻NO独立相关。鼻NO在鼻阻塞得分小于7(轻度到中度阻塞)的患者中的水平与对照相比,具有显著的增加(282.1 ± 122.6 vs 150.7 ± 48.4 ppb; p < 0.001),并且在鼻阻塞得分不小于7(重度阻塞)的病人中显著减少(97.2 ± 52.2 vs 150.7 ± 48.4 ppb; p < 0.001)。在轻度到中度鼻阻塞病人中,鼻NO与ECP呈现正相关关系,但是在重度鼻阻塞病人中不存在正相关关系(r=0.077)。在NAR小于0.65 Pa/cm3 /s的病人中,NO和ECP的相关系数最高(r=0.685)。另外,在鼻阻塞得分小于7和NAR小于0.65 Pa/cm3 /s的病人中,鼻NO水平的接受者操作特征曲线下面积分别为0.878和0.939。

最后,研究人员指出,鼻腔开放情况能够显著的影响NO水平,并且能够反映在轻度到中度鼻阻塞病人中的AR鼻炎症情况,但是并不能反映重度阻塞病人的鼻炎症情况。

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    2018-02-02 膀胱癌
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    2018-01-31 弗洛伦蒂诺

    被鼻炎弄得很烦.好多年了

    0

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    2018-01-31 龙胆草

    学习谢谢分享

    0

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    2018-01-31 1ddf0692m34(暂无匿称)

    学习了.涨知识

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    2018-01-31 1e0f8808m18(暂无匿称)

    学习了.谢谢分享.

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