日本借助3D打印导管成功让老鼠坐骨神经再生

2017-03-09 佚名 天工社

近日,在日本京都大学矫形外科学系教授Ryosuke Ikeguchi的领导下,13名日本研究人员成功地在老鼠身上测试了3D打印导管在神经再生中的功效。

近日,在日本京都大学矫形外科学系教授Ryosuke Ikeguchi的领导下,13名日本研究人员成功地在老鼠身上测试了3D打印导管在神经再生中的功效。


目前,医学界对周围神经损伤的普遍治疗方法是自体神经移植,医生会从患者身上的另一部位获取神经节段来修复神经系统中的病变间隙。这一方法被证明是有效的,但问题是医生并不是总能成功地从患者身上获取神经片段,此时如果患者找不到捐献者,那么疾病就无法被治疗。

日本借助3D打印导管成功让老鼠坐骨神经再生

A:预先设计好的3D管状结构    B:根据A制作的3D打印导管

据天工社了解,作为替代解决方案,Ikeguchi的研究团队测试了3D打印导管的功效。他们将正常人的皮肤成纤维细胞作为基础材料,用高性能3D生物打印机制造出无支架的导管作为神经组织。在实验过程中,研究人员在十二只成年雄性老鼠身上测试了这些3D打印导管的适应性。为了研究3D打印导管在再生神经组织和节段中的效果,他们收集了有免疫缺陷的老鼠,这些老鼠右侧坐骨神经的大腿中部处被切断。在一个与自体神经移植类似的过程中,研究人员用3D打印导管来连接老鼠的病变间隙。

日本借助3D打印导管成功让老鼠坐骨神经再生

A:植入3D打印导管    B:植入硅胶导管

在实验的第二阶段,研究人员收集了这些老鼠的数据,并将其与用硅胶导管进行治疗的一组老鼠进行比较。在一系列电生理研究中,研究人员发现使用3D打印导管的老鼠组更有可能做出高级复合肌肉动作

“我们确认,在老鼠坐骨神经实验中,完全由成纤维细胞构成的无支架生物3D导管能促进神经再生,”研究人员宣称。这再次展示了3D打印技术在复杂的临床手术中的灵活性。

日本借助3D打印导管成功让老鼠坐骨神经再生

A:使用3D打印导管的老鼠的神经再生情况    B:使用硅胶导管的老鼠的神经再生情况

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    2017-09-09 心欲无痕 无欲则刚

    太神奇了

    0

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    2017-03-11 智智灵药
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    2017-03-09 明天会更好!

    真的有这么神奇?

    0

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    2017-03-09 蔬菜

    是不是真的?一根导管竟有如此神效

    0

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