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Circulation：细胞因子样蛋白DKK3具有抗动脉粥样硬化作用

2017-07-04 xiangting MedSci原创

DKK3动脉粥样硬化动物模型心血管疾病内皮细胞
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这项研究提供了DKK3在抗动脉粥样硬化中作用的证据，其中涉及了内皮迁移和修复。

Dickkopf相关蛋白（DKK）3是一种参与调节心脏重塑和血管平滑肌细胞分化的分泌蛋白，但对其在动脉粥样硬化中的作用知之甚少。

研究人员使用流行病学和实验的方法验证DKK3具有抗动脉粥样硬化作用的假说。在2000年（n = 684）和2005年（n = 574）的Bruneck研究中检测血DKK3水平。DKK3缺陷小鼠与 ApoE -/-小鼠比较，以评估动脉粥样硬化发展和血管损伤诱导的新内膜形成。使用体外细胞培养模型研究内皮细胞迁移及其潜在机制。

在基于人群的前瞻性Bruneck研究中，血浆DKK3的水平与颈动脉内膜-中膜厚度和颈动脉粥样硬化的五年进展成反比，与动脉粥样硬化的标准危险因素无关。实验上，研究人员分析了 DKK3 -/- / ApoE-/-和 DKK3 +/+ / ApoE -/-小鼠动脉粥样硬化病变区域，股动脉损伤诱导的内皮细胞再生和新内膜的形成。证实DKK3缺乏加速动脉粥样硬化并延迟再内皮化，从而加剧新内膜形成。为了探索潜在的机制，使用培养的人内皮细胞进行跨槽和划痕迁移实验，其在DKK3刺激下细胞迁移中表现出显著的诱导作用。这种DKK3诱导的迁移与ROR2和DVL1活化，Rac1 GTP酶的激活和内皮细胞中上调的JNK和c-jun磷酸化有关。使用特异性siRNA敲除ROR2受体或在内皮细胞中转染负显性形式的Rac1显著抑制细胞迁移和下游JNK和c-jun磷酸化。

这项研究提供了DKK3在抗动脉粥样硬化中作用的证据，其中涉及了内皮迁移和修复，DKK3对动脉粥样硬化有很大的治疗潜力。

原始出处：
Baoqi Yu, Stefan Kiechl, Dan Qi，et al. A Cytokine-like Protein DKK3 Is Atheroprotective. Circulation. 3 July 2017.

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    2017-12-13 仁医06

    #胞因子#

    0

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    2017-10-02 1249857fm32暂无昵称

    #DKK3#

    0

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    2018-01-02 huangshifeng

    #粥样硬化#

    0

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    2017-07-10 大爰

    学习了谢谢分享！！

    0

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    2017-07-06 axin009

    #细胞因子#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1809546, encodeId=b02418095468c, content=<a href='/topic/show?id=6cd683e603b' target=_blank style='color:#2F92EE;'>#胞因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83760, encryptionId=6cd683e603b, topicName=胞因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Wed Dec 13 08:15:00 CST 2017, time=2017-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2005905, encodeId=c6b32005905e3, content=<a href='/topic/show?id=678260259a' target=_blank style='color:#2F92EE;'>#DKK3#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6025, encryptionId=678260259a, topicName=DKK3)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca282500032, createdName=1249857fm32暂无昵称, createdTime=Mon Oct 02 09:15:00 CST 2017, time=2017-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1944470, encodeId=aa8d19444e064, content=<a href='/topic/show?id=411de6300ad' target=_blank style='color:#2F92EE;'>#粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76300, encryptionId=411de6300ad, topicName=粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b30d401, createdName=huangshifeng, createdTime=Tue Jan 02 15:15:00 CST 2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220663, encodeId=82c1220663af, content=学习了谢谢分享！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Mon Jul 10 09:10:26 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1283580, encodeId=eecb12835809f, content=<a href='/topic/show?id=2c00e784416' target=_blank style='color:#2F92EE;'>#细胞因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77844, encryptionId=2c00e784416, topicName=细胞因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0ad8182, createdName=axin009, createdTime=Thu Jul 06 01:15:00 CST 2017, time=2017-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218501, encodeId=252b218501e5, content=好好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Tue Jul 04 13:21:24 CST 2017, time=2017-07-04, status=1, ipAttribution=)]
    2017-07-04 139****5926

    好好文章学习了

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