Radiology:磁化转移MR成像在Crohn病肠壁纤维化程度的价值

2018-02-02 shaosai MedSci原创

本研究旨在评价磁化转移(MT)磁共振(MR)成像在显示Crohn病(CD)肠壁纤维化程度及鉴别其与炎症改变的价值,并将结果发表在Radiology上。

本研究旨在评价磁化转移(MT)磁共振(MR)成像在显示Crohn病(CD)肠壁纤维化程度及鉴别其与炎症改变的价值,并将结果发表在Radiology上。

本研究共纳入了31例行术前腹部MR成像、对比增强成像和扩散加权成像的CD患者。肠壁MT比通过与骨骼肌标准化,计算表观扩散系数(ADC)和强化比值;各部位与手术标本相对应来验证组织学上纤维化和炎症的程度。在另外5例患者中验证MT成像的价值。利用单方向方差分析、Spearman等级相关和ROC曲线进行统计学分析。

结果为,标准化MT比与纤维化评分具有明显的相关性(r = 0.769; P = .000),而与炎症评分无明显相关性(r = -0.034; P = .740)。在非纤维化、轻度纤维化、中度纤维化和中度纤维化肠壁中,标准化MT比具有显着差异性(F = 49.002; P = .000)。具有纤维化和炎症的肠壁标准化MT比要明显高于只有炎症的肠壁MT比(t = -8.52; P = .000)。标准化MT比鉴别中重度肠壁纤维化与无及轻度肠壁纤维化的准确率较高,ROC曲线下面积(AUC)为0.919 (P = .000),其次为ADC (AUC, 0.747; P = .001)和强化比(AUC, 0.592; P = .209)。在验证组MT成像诊断中重度纤维化的敏感性、特异性及AUC分布为80% (12/15)、 100% (3/3),、0.9 (P = .033)。

本研究表明MR成像在检出及鉴别有无合并炎症的不同程度肠壁纤维化的能力要优于ADC及对比增强成像。MT成像有望成为鉴别CD患者肠壁纤维化与炎症的一种有效方法。

原始出处:


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    2018-02-05 虈亣靌

    非常好.谢谢分享

    0

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    2018-02-03 cscdliu

    学习了.谢谢

    0