Eur Ann Allergy Clin Immunol:来自意大利的代表性的多中心调查:维他命D和过敏性疾病

2017-04-08 AlexYang MedSci原创

在过去的二十年中,人们对维生素D(VD)在过敏性疾病中的作用的兴趣日益增加。除了维生素D在骨代谢中的著名作用,最近的研究表明了它可能有过敏免疫调控子的角色。最近,研究人员就VD水平与过敏性的关系进行了探索。研究是在意大利本土中进行的,研究人员评估了血清中VD的水平与诊断性过敏疾病(鼻炎/哮喘、食物过敏和过敏性皮肤炎)可能的联系。另外,VD是在医师诊断的过敏性疾病中进行评估的。该研究的地点为公立医院

在过去的二十年中,人们对维生素D(VD)在过敏性疾病中的作用的兴趣日益增加。除了维生素D在骨代谢中的著名作用,最近的研究表明了它可能有过敏免疫调控子的角色。

最近,研究人员就VD水平与过敏性的关系进行了探索。研究是在意大利本土中进行的,研究人员评估了血清中VD的水平与诊断性过敏疾病(鼻炎/哮喘、食物过敏和过敏性皮肤炎)可能的联系。另外,VD是在医师诊断的过敏性疾病中进行评估的。

该研究的地点为公立医院和私人医院,时间为2012年11月到2013年3月,总共有18个中心参与。研究群体为成人并且参与者至少有一种阳性皮刺测试。诊断程序和资料收集在不同的中心是标准化的,并且VD水平在同一个实验室进行检测。

研究群体包括了309名病人,其中有132名男性,平均年龄为37.5 ±17。研究结果表明,在该研究群体中,40%报道具有阳性家族过敏历史(哮喘/鼻炎),47%的病人表现鼻炎和哮喘,15%病人表现为过敏性皮肤炎,食物过敏相同的临床历史结合阳性皮肤测试占25%。VD水平和年龄、性别、家族历史、鼻炎或者食物过敏没有显着的关联。VD水平在哮喘和鼻炎病人中较低,但是没有统计学显着性。而在患有或不患有过敏性皮炎的病人中,VD水平具有显着的差异。另外,VD与季节性过敏没有关系,但是与房间尘螨和狗毛皮屑呈显着的负相关关系。最后,研究人员指出,他们的过敏性病人的代表性研究数据与目前文献的报道只有部分吻合,并且VD水平与过敏的关系似乎较弱。研究人员表示,更大群体的研究是需要的,从而更好的确定VD与过敏的关系。

原始出处:

Lombardi C, Passalacqua G,Italian Vitamin D Allergy Group. Vitamin D levels and allergic diseases. An italian cross-sectional multicenter survey. Eur Ann Allergy Clin Immunol. March 2017.

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    2017-04-26 往日如昨

    学习了谢谢分享

    0

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    2017-04-12 Chongyang Zhang

    签到学习了很多。

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1903913, encodeId=4d60190391393, content=<a href='/topic/show?id=7d454302945' target=_blank style='color:#2F92EE;'>#多中心#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43029, encryptionId=7d454302945, topicName=多中心)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=02f5179, createdName=luoxiaog, createdTime=Fri Jan 12 16:32:00 CST 2018, time=2018-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2046819, encodeId=81132046819a2, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Sat Mar 17 02:32:00 CST 2018, time=2018-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190729, encodeId=59af190e2979, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Wed Apr 26 10:11:47 CST 2017, time=2017-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186846, encodeId=aaa7186846c5, content=签到学习了很多。, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/A3E53E62691178E2F18D7B999FD22131/100, createdBy=f44d2003846, createdName=Chongyang Zhang, createdTime=Wed Apr 12 09:41:58 CST 2017, time=2017-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1328931, encodeId=39321328931a1, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Mon Apr 10 05:32:00 CST 2017, time=2017-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1385396, encodeId=013b1385396d8, content=<a href='/topic/show?id=c31c5322844' target=_blank style='color:#2F92EE;'>#意大利#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53228, encryptionId=c31c5322844, topicName=意大利)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Mon Apr 10 05:32:00 CST 2017, time=2017-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186019, encodeId=ceea186019be, content=讲的非常好非常棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eo2GMhevabZrvYIDhcYQOadp8uNxP2luzicRh5E0OHqMU9kYxib3dV5Qsd9UASTrkcc9ibiaN90Zwo1Tw/132, createdBy=275f1684782, createdName=wang_shengli, createdTime=Sat Apr 08 19:09:24 CST 2017, time=2017-04-08, status=1, ipAttribution=)]
    2017-04-10 膀胱癌
  6. [GetPortalCommentsPageByObjectIdResponse(id=1903913, encodeId=4d60190391393, content=<a href='/topic/show?id=7d454302945' target=_blank style='color:#2F92EE;'>#多中心#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43029, encryptionId=7d454302945, topicName=多中心)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=02f5179, createdName=luoxiaog, createdTime=Fri Jan 12 16:32:00 CST 2018, time=2018-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2046819, encodeId=81132046819a2, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Sat Mar 17 02:32:00 CST 2018, time=2018-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190729, encodeId=59af190e2979, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Wed Apr 26 10:11:47 CST 2017, time=2017-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186846, encodeId=aaa7186846c5, content=签到学习了很多。, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/A3E53E62691178E2F18D7B999FD22131/100, createdBy=f44d2003846, createdName=Chongyang Zhang, createdTime=Wed Apr 12 09:41:58 CST 2017, time=2017-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1328931, encodeId=39321328931a1, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Mon Apr 10 05:32:00 CST 2017, time=2017-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1385396, encodeId=013b1385396d8, content=<a href='/topic/show?id=c31c5322844' target=_blank style='color:#2F92EE;'>#意大利#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53228, encryptionId=c31c5322844, topicName=意大利)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Mon Apr 10 05:32:00 CST 2017, time=2017-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186019, encodeId=ceea186019be, content=讲的非常好非常棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eo2GMhevabZrvYIDhcYQOadp8uNxP2luzicRh5E0OHqMU9kYxib3dV5Qsd9UASTrkcc9ibiaN90Zwo1Tw/132, createdBy=275f1684782, createdName=wang_shengli, createdTime=Sat Apr 08 19:09:24 CST 2017, time=2017-04-08, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1903913, encodeId=4d60190391393, content=<a href='/topic/show?id=7d454302945' target=_blank style='color:#2F92EE;'>#多中心#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43029, encryptionId=7d454302945, topicName=多中心)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=02f5179, createdName=luoxiaog, createdTime=Fri Jan 12 16:32:00 CST 2018, time=2018-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2046819, encodeId=81132046819a2, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Sat Mar 17 02:32:00 CST 2018, time=2018-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190729, encodeId=59af190e2979, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Wed Apr 26 10:11:47 CST 2017, time=2017-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186846, encodeId=aaa7186846c5, content=签到学习了很多。, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/A3E53E62691178E2F18D7B999FD22131/100, createdBy=f44d2003846, createdName=Chongyang Zhang, createdTime=Wed Apr 12 09:41:58 CST 2017, time=2017-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1328931, encodeId=39321328931a1, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Mon Apr 10 05:32:00 CST 2017, time=2017-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1385396, encodeId=013b1385396d8, content=<a href='/topic/show?id=c31c5322844' target=_blank style='color:#2F92EE;'>#意大利#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53228, encryptionId=c31c5322844, topicName=意大利)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Mon Apr 10 05:32:00 CST 2017, time=2017-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186019, encodeId=ceea186019be, content=讲的非常好非常棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eo2GMhevabZrvYIDhcYQOadp8uNxP2luzicRh5E0OHqMU9kYxib3dV5Qsd9UASTrkcc9ibiaN90Zwo1Tw/132, createdBy=275f1684782, createdName=wang_shengli, createdTime=Sat Apr 08 19:09:24 CST 2017, time=2017-04-08, status=1, ipAttribution=)]
    2017-04-08 wang_shengli

    讲的非常好非常棒

    0