JAMA Ophthalmol:寨卡病毒感染眼部病变临床表现

2017-04-14 MedSci MedSci原创

寨卡病毒感染眼部后遗症表现为局灶性色素斑,黄斑区脉络膜视网膜萎缩、先天性青光眼、视神经发育不全和视盘异常等

寨卡病毒感染眼部后遗症的临床表现目前很清楚。最近,世界卫生组织认定寨卡病毒为公共卫生紧急事件并制定了长期工作计划应对病毒爆发导致的胎儿小头畸形。这种变化表明迫使研究人员对寨卡病毒感染眼部后遗症进行评估和处置。研究者为此研究了在哥伦比亚和委内瑞拉报告的先天性小头畸形寨卡综合征及其眼部病变表现情况。

这项前瞻性病例评估在哥伦比亚和委内瑞拉2个眼科中心进行,从2015年10月1日起至2016年6月30日,共确诊43例先天性病毒综合征病人,包括20例西班牙裔;13例非洲裔;8例白人和2例美洲原住民。对所有婴儿进行眼科和全身评估和血清学试验,眼科检测包括患者眼外检查、散瞳眼底检查;血清学试验排除弓形虫病,风疹,巨细胞病毒,梅毒和人类免疫缺陷病毒。

研究涉及的患儿中,28名女婴,15名男婴,平均月龄2.1个月(SD 1.5)。所有患儿的母亲均无眼科疾病且在怀孕期间未报告眼部症状。所有患儿均有双侧眼部病变,其中5名患儿(11.6%)有先天性视神经发育不全、27名患儿(63%)患有轻度到重度色素斑性黄斑病变、3人(6.9%)患有腔隙性黄斑病变、3人有视网膜脉络膜瘢痕(7%)、11人(26%)有后极合并病变、5人(12%)确诊为先天性青光眼。数据表明,12%(95% CI 5%-24%)先天性畸形寨卡患儿存在眼前节异常;88%(95% CI 76%-94%)先天性畸形有寨卡患儿有严重的黄斑和视神经异常。这些眼部病变的视觉后遗症目前尚不知晓。

研究表明目前寨卡病毒感染眼部后遗症表现为局灶性色素斑,黄斑区脉络膜视网膜萎缩、先天性青光眼、视神经发育不全和视盘异常等。

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    2018-03-30 huiwelcome
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    2017-05-01 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

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    2017-04-26 往日如昨

    学习了谢谢分享

    0

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  6. [GetPortalCommentsPageByObjectIdResponse(id=1776053, encodeId=59a81e7605375, content=<a href='/topic/show?id=508ae2913d6' target=_blank style='color:#2F92EE;'>#眼部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72913, encryptionId=508ae2913d6, topicName=眼部)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=126338864246, createdName=huiwelcome, createdTime=Fri Mar 30 13:39:00 CST 2018, time=2018-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192395, encodeId=11be19239561, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Mon May 01 07:16:23 CST 2017, time=2017-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190728, encodeId=a79e190e2860, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Wed Apr 26 10:11:09 CST 2017, time=2017-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1360069, encodeId=7eaf13600690c, content=<a href='/topic/show?id=6783466083f' target=_blank style='color:#2F92EE;'>#寨卡病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46608, encryptionId=6783466083f, topicName=寨卡病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=583c133, createdName=yuandd, createdTime=Sun Apr 16 00:39:00 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512915, encodeId=560e1512915de, content=<a href='/topic/show?id=f0364660360' target=_blank style='color:#2F92EE;'>#寨卡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46603, encryptionId=f0364660360, topicName=寨卡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d79610514526, createdName=12498710m14暂无昵称, createdTime=Sun Apr 16 00:39:00 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1541188, encodeId=3928154118840, content=<a href='/topic/show?id=5c961e37307' target=_blank style='color:#2F92EE;'>#THA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17373, encryptionId=5c961e37307, topicName=THA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=615b13300589, createdName=1249842em13(暂无昵称), createdTime=Sun Apr 16 00:39:00 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187365, encodeId=aab618e365ad, content=mark, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/02/48d1fec880a796cc2ad284d7b18e6017.jpg, createdBy=43e51704272, createdName=九天., createdTime=Fri Apr 14 14:10:07 CST 2017, time=2017-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187360, encodeId=97e918e360f1, content=mark, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/02/48d1fec880a796cc2ad284d7b18e6017.jpg, createdBy=43e51704272, createdName=九天., createdTime=Fri Apr 14 14:07:01 CST 2017, time=2017-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187317, encodeId=7b3e18e31747, content=学习,受益匪浅!, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Fri Apr 14 10:17:47 CST 2017, time=2017-04-14, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1776053, encodeId=59a81e7605375, content=<a href='/topic/show?id=508ae2913d6' target=_blank style='color:#2F92EE;'>#眼部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72913, encryptionId=508ae2913d6, topicName=眼部)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=126338864246, createdName=huiwelcome, createdTime=Fri Mar 30 13:39:00 CST 2018, time=2018-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=192395, encodeId=11be19239561, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Mon May 01 07:16:23 CST 2017, time=2017-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190728, encodeId=a79e190e2860, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Wed Apr 26 10:11:09 CST 2017, time=2017-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1360069, encodeId=7eaf13600690c, content=<a href='/topic/show?id=6783466083f' target=_blank style='color:#2F92EE;'>#寨卡病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46608, encryptionId=6783466083f, topicName=寨卡病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=583c133, createdName=yuandd, createdTime=Sun Apr 16 00:39:00 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512915, encodeId=560e1512915de, content=<a href='/topic/show?id=f0364660360' target=_blank style='color:#2F92EE;'>#寨卡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46603, encryptionId=f0364660360, topicName=寨卡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d79610514526, createdName=12498710m14暂无昵称, createdTime=Sun Apr 16 00:39:00 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1541188, encodeId=3928154118840, content=<a href='/topic/show?id=5c961e37307' target=_blank style='color:#2F92EE;'>#THA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17373, encryptionId=5c961e37307, topicName=THA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=615b13300589, createdName=1249842em13(暂无昵称), createdTime=Sun Apr 16 00:39:00 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187365, encodeId=aab618e365ad, content=mark, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/02/48d1fec880a796cc2ad284d7b18e6017.jpg, createdBy=43e51704272, createdName=九天., createdTime=Fri Apr 14 14:10:07 CST 2017, time=2017-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187360, encodeId=97e918e360f1, content=mark, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/02/48d1fec880a796cc2ad284d7b18e6017.jpg, createdBy=43e51704272, createdName=九天., createdTime=Fri Apr 14 14:07:01 CST 2017, time=2017-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187317, encodeId=7b3e18e31747, content=学习,受益匪浅!, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Fri Apr 14 10:17:47 CST 2017, time=2017-04-14, status=1, ipAttribution=)]
    2017-04-14 九天.

    mark

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    2017-04-14 九天.

    mark

    0

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    2017-04-14 执着追梦

    学习,受益匪浅!

    0

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