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Mol Aspects Med：PDGF-C和PDGF-D在眼部疾病中的作用！

2017-11-17 MedSci MedSci原创

PDGF-CPDGF-D眼部疾病
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中山大学中山眼科中心眼科国家重点实验室的Kumar A近日在Mol Aspects Med杂志上发表了他们近期的一篇综述，系统性的总结了PDGF-C和PDGF-D在生物学和一些相关眼部疾病中的最新研究进展。

中山大学中山眼科中心眼科国家重点实验室的Kumar A近日在Mol Aspects Med杂志上发表了他们近期的一篇综述，系统性的总结了PDGF-C和PDGF-D在生物学和一些相关眼部疾病中的最新研究进展。

PDGF及其受体是许多组织和器官（包括眼睛）的重要调节因子。大量的研究表明，PDGF及其受体在许多眼新生血管疾病中起关键的作用，如新生血管的年龄相关性黄斑变性、早产儿视网膜病变和增生性玻璃体视网膜病变。此外，PDGF和PDGFR对于视网膜神经元和血管细胞的病变具有重要的作用，例如青光眼和色素性视网膜炎病变。由于PDGF和PDGFR在许多致盲性眼部疾病的发病机理中具有关键作用，因此，PDGF和PDGFR被认为是治疗眼睛疾病的重要靶分子。

PDGF-C和PDGF-D是PDGF家族的新成员，对于血管生成和存活具有重要的作用。最近的研究表明，它们在不同类型的眼睛疾病中起重要作用。因此，调节PDGF-C和PDGF-D的活性对于治疗眼新生血管和退行性疾病具有治疗价值。这篇综述主要总结了PDGF-C和PDGF-D在生物学和一些相关眼部疾病中的最新进展。

原文出处：

Kumar， A. and X. Li  PDGF-C and PDGF-D in ocular diseases. Mol Aspects Med， 2017.

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    2018-01-14 huiwelcome

    #眼部#

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    2018-01-02 liye789132259

    #ASPECTS#

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    2018-09-08 feather89

    #PE#

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CST 2017, time=2017-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=262102, encodeId=e81426210237, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Fri Nov 17 22:52:47 CST 2017, time=2017-11-17, status=1, ipAttribution=)]
    2018-09-17 slcumt

    #眼部疾病#

    0

  5. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sat Nov 18 07:15:35 CST 2017, time=2017-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=262104, encodeId=21ab2621041a, content=大量的研究表明.PDGF及其受体在许多眼新生血管疾病中起关键的作用.如新生血管的年龄相关性黄斑变性.早产儿视网膜病变和增生性玻璃体视网膜病变, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Fri Nov 17 22:58:08 CST 2017, time=2017-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=262102, encodeId=e81426210237, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Fri Nov 17 22:52:47 CST 2017, time=2017-11-17, status=1, ipAttribution=)]
    2017-11-19 docwu2019

    #CTS#

    0

  6. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sat Nov 18 07:15:35 CST 2017, time=2017-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=262104, encodeId=21ab2621041a, content=大量的研究表明.PDGF及其受体在许多眼新生血管疾病中起关键的作用.如新生血管的年龄相关性黄斑变性.早产儿视网膜病变和增生性玻璃体视网膜病变, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Fri Nov 17 22:58:08 CST 2017, time=2017-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=262102, encodeId=e81426210237, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Fri Nov 17 22:52:47 CST 2017, time=2017-11-17, status=1, ipAttribution=)]
    2017-11-19 一叶知秋

    #Med#

    0

  7. 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topicList=[TopicDto(id=72926, encryptionId=cccee2926dc, topicName=眼部疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f9279, createdName=slcumt, createdTime=Mon Sep 17 23:49:00 CST 2018, time=2018-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461946, encodeId=36931461946d1, content=<a href='/topic/show?id=10bf5438bc' target=_blank style='color:#2F92EE;'>#CTS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5438, encryptionId=10bf5438bc, topicName=CTS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sun Nov 19 12:49:00 CST 2017, time=2017-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608263, encodeId=deb916082633e, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sat Nov 18 07:15:35 CST 2017, time=2017-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=262104, encodeId=21ab2621041a, content=大量的研究表明.PDGF及其受体在许多眼新生血管疾病中起关键的作用.如新生血管的年龄相关性黄斑变性.早产儿视网膜病变和增生性玻璃体视网膜病变, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Fri Nov 17 22:58:08 CST 2017, time=2017-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=262102, encodeId=e81426210237, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Fri Nov 17 22:52:47 CST 2017, time=2017-11-17, status=1, ipAttribution=)]
    2017-11-18 执着追梦

    学习.谢谢分享

    0

  8. 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objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sun Nov 19 12:49:00 CST 2017, time=2017-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=262202, encodeId=15be262202fd, content=学习.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Sat Nov 18 08:05:31 CST 2017, time=2017-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=262166, encodeId=b401262166f5, content=特意看看不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sat Nov 18 07:15:35 CST 2017, time=2017-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=262104, encodeId=21ab2621041a, content=大量的研究表明.PDGF及其受体在许多眼新生血管疾病中起关键的作用.如新生血管的年龄相关性黄斑变性.早产儿视网膜病变和增生性玻璃体视网膜病变, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Fri Nov 17 22:58:08 CST 2017, time=2017-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=262102, encodeId=e81426210237, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Fri Nov 17 22:52:47 CST 2017, time=2017-11-17, status=1, ipAttribution=)]
    2017-11-18 飛歌

    特意看看不错

    0

  9. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sat Nov 18 07:15:35 CST 2017, time=2017-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=262104, encodeId=21ab2621041a, content=大量的研究表明.PDGF及其受体在许多眼新生血管疾病中起关键的作用.如新生血管的年龄相关性黄斑变性.早产儿视网膜病变和增生性玻璃体视网膜病变, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Fri Nov 17 22:58:08 CST 2017, time=2017-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=262102, encodeId=e81426210237, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Fri Nov 17 22:52:47 CST 2017, time=2017-11-17, status=1, ipAttribution=)]
    2017-11-17 有备才能无患

    大量的研究表明.PDGF及其受体在许多眼新生血管疾病中起关键的作用.如新生血管的年龄相关性黄斑变性.早产儿视网膜病变和增生性玻璃体视网膜病变

    0

  10. 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topicList=[TopicDto(id=72926, encryptionId=cccee2926dc, topicName=眼部疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f9279, createdName=slcumt, createdTime=Mon Sep 17 23:49:00 CST 2018, time=2018-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461946, encodeId=36931461946d1, content=<a href='/topic/show?id=10bf5438bc' target=_blank style='color:#2F92EE;'>#CTS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5438, encryptionId=10bf5438bc, topicName=CTS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sun Nov 19 12:49:00 CST 2017, time=2017-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608263, encodeId=deb916082633e, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sat Nov 18 07:15:35 CST 2017, time=2017-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=262104, encodeId=21ab2621041a, content=大量的研究表明.PDGF及其受体在许多眼新生血管疾病中起关键的作用.如新生血管的年龄相关性黄斑变性.早产儿视网膜病变和增生性玻璃体视网膜病变, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Fri Nov 17 22:58:08 CST 2017, time=2017-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=262102, encodeId=e81426210237, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Fri Nov 17 22:52:47 CST 2017, time=2017-11-17, status=1, ipAttribution=)]
    2017-11-17 1e1b8538m79(暂无匿称)

    不错的文章值得推荐

    0

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