AJG: 新冠肺炎(COVID-19)感染的患者中胃肠道症状的患病率分析

2021-12-22 MedSci原创 MedSci原创

新冠肺炎一般指新型冠状病毒肺炎。 新型冠状病毒肺炎(Corona Virus Disease 2019,COVID-19),简称“新冠肺炎”,世界卫生组织命名为“2019冠状病毒病”。

新冠肺炎COVID-19)患者若出现胃肠症状将有更高几率发展为重症。虽然新冠病毒引起的疾病名称是肺炎,但该病毒的受体在全身几乎所有组织中都有表达,尤其在胃肠道有很高的表达。更为重要的是,研究发现,腹泻症状和新冠病毒感染重症、呼吸机的使用以及ICU病房的使用也有显著的相关。因此,本项研究旨在在住院患者中评估胃肠道(GI)症状的患病率、与其发生相关的因素以及 1 个月时的病情变化。

 

GI-COVID-19 是一项前瞻性、多中心、对照研究。研究人员招募了在入院时确诊和未确诊 COVID-19 的患者,并在入院时和 1 个月后使用经过验证的胃肠道症状评定量表问卷询问胃肠道症状,最后进行了相关性分析。

 

研究结果显示:该研究包括 2036 名住院患者,其中共包括 871 名患者(575 名 COVID-19+(阳性) 和 296 名 COVID-19-(阴性))。与对照组(43.2%;128/296 名患者)相比,COVID-19 患者(59.7%;343/575 名患者)的胃肠道症状发生频率更高(P < 0.001)。与对照组相比,COVID-19 患者抱怨恶心、腹泻、稀便和尿急的出现或程度更高。在 1 个月的随访中,发现住院时有胃肠道症状的 COVID-19 患者胃肠道症状的存在或强度有所降低,恶心仍然比对照组增加。与 COVID-19 中持续恶心显着相关的因素是女性、高体重指数、呼吸困难的存在和 C 反应蛋白水平升高。

 

本项研究证实:COVID-19 住院患者胃肠道症状的患病率高于对照组。全身和呼吸道症状通常与胃肠道不适有关,但是在 COVID-19 感染消退后,恶心可能会持续存在。

原始出处:

Marasco, Giovanni MD. Et al. Prevalence of Gastrointestinal Symptoms in Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Results of the Prospective Controlled Multinational GI-COVID-19 Study. The American Journal of Gastroenterology.2021.

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    2022-09-15 minzju5052
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    2021-12-24 黑暗独白

    好难

    0

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