Am Heart J :持续吸烟:STEMI年轻患者长期预后强独立预测因子

2015-03-18 张旭栋译 MedSci原创

来自希腊雅典University General Hospital "Attikon"的Loukianos S. Rallidis博士等人研究了早期发生过急性心肌梗死的年轻存活患者,吸烟对预后的影响,研究成果发表在3月份American heart journal期刊上。 背景:有关急性心肌梗死(AMI)年轻幸存者的长期预后数据非常少。研究探索了患过早期ST段抬高性心肌梗死患者的长期

来自希腊雅典University General Hospital "Attikon"的Loukianos S. Rallidis博士等人研究了早期发生过急性心肌梗死的年轻存活患者,吸烟对预后的影响,研究成果发表在3月份American heart journal期刊上。
 
背景:有关急性心肌梗死(AMI)年轻幸存者的长期预后数据非常少。研究探索了患过早期ST段抬高性心肌梗死患者的长期预后。
 
方法:研究招募了257例患者(首次发生急性心肌梗死年龄≤35years,并存活下来的患者)。为期进行了长达18年的随访。临床终点包括了所有主要冠脉不良事件(MACE):心源性猝死,急性冠脉综合征在住院,心律失常或因临床恶化而行冠状动脉血运重建。
 
结果:最主要的危险因素是吸烟(93.7%)。从237例患者(32.2±3.7年岁)中采集随访数据。中位随访时间为9.1年。在随访期间,有139例患者(58.6%)吸烟。91例患者(38.4%)再次发生主要冠脉不良事件(其中,13例患者死亡,59例患者诊断为急性冠脉综合征,2例患者心律失常,17例患者进行血运重建)。多元Cox回归分析显示,持续吸烟,左心室射血分数(LVEF),以及再灌注治疗(溶栓或主要冠状动脉成形术)主要冠脉不良事件的独立预测因子(调整传统风险因子)。持续吸烟仍然是主要的冠脉不良事件,其中:LVEF调整后,危险比为2.154,95%可信区间1.313-3.535,P = 0.002;或再灌注治疗调整后,危险比为2.327,95%可信区间1.423-3.804,P = 0.001 )。哈勒尔C统计结果显示,与LVEF或再灌注治疗模型相比,持续吸烟模型有着更好的区分能力。
 
结论:在他汀类药物和治疗再灌注的时代,对于早期发生AMI存活的年轻患者,持续吸烟是主要冠脉不良事件较强的独立预测因子。

原文出处:
 
Rallidis LS, Sakadakis EA, Tympas K, Varounis C, Zolindaki M, Dagres N, Lekakis J. The impact of smoking on long-term outcome of patients with premature (. American heart journal. 2015;169(3):356-62

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    2016-01-21 kellerni

    心梗年轻化,吸烟脱不了干系

    0

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    2015-03-20 medcardio

    燃烧的是生命哦

    0

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  5. [GetPortalCommentsPageByObjectIdResponse(id=58619, encodeId=a4ab586191d, content=心梗年轻化,吸烟脱不了干系, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c8c11605398, createdName=kellerni, createdTime=Thu Jan 21 10:40:00 CST 2016, time=2016-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1645553, encodeId=65bb16455533d, content=<a href='/topic/show?id=79d99e04630' target=_blank style='color:#2F92EE;'>#长期预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97046, encryptionId=79d99e04630, topicName=长期预后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0e4823226485, createdName=ymljack, createdTime=Fri Apr 17 17:08:00 CST 2015, time=2015-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=18577, encodeId=eeda185e771, content=燃烧的是生命哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Fri Mar 20 23:29:00 CST 2015, time=2015-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1310598, encodeId=2b861310598ff, content=<a href='/topic/show?id=25dc1002255e' target=_blank style='color:#2F92EE;'>#预测因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100225, encryptionId=25dc1002255e, topicName=预测因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6105386, createdName=宋威, createdTime=Fri Mar 20 06:08:00 CST 2015, time=2015-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355978, encodeId=256413559e807, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Mar 20 06:08:00 CST 2015, time=2015-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481858, encodeId=007e1481858d8, content=<a href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Fri Mar 20 06:08:00 CST 2015, time=2015-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1525681, encodeId=32911525681e8, content=<a href='/topic/show?id=e96e489842a' target=_blank style='color:#2F92EE;'>#年轻患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48984, encryptionId=e96e489842a, topicName=年轻患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aab511654279, createdName=minzju5056, createdTime=Fri Mar 20 06:08:00 CST 2015, time=2015-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562303, encodeId=6a25156230384, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Fri Mar 20 06:08:00 CST 2015, time=2015-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=18473, encodeId=e0c7184e395, content=抽的不是烟啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=drhqh240, createdTime=Wed Mar 18 20:49:00 CST 2015, time=2015-03-18, status=1, ipAttribution=)]
    2015-03-20 zhaojie88
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  7. [GetPortalCommentsPageByObjectIdResponse(id=58619, encodeId=a4ab586191d, content=心梗年轻化,吸烟脱不了干系, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c8c11605398, createdName=kellerni, createdTime=Thu Jan 21 10:40:00 CST 2016, time=2016-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1645553, encodeId=65bb16455533d, content=<a href='/topic/show?id=79d99e04630' target=_blank style='color:#2F92EE;'>#长期预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97046, encryptionId=79d99e04630, topicName=长期预后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0e4823226485, createdName=ymljack, createdTime=Fri Apr 17 17:08:00 CST 2015, time=2015-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=18577, encodeId=eeda185e771, content=燃烧的是生命哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Fri Mar 20 23:29:00 CST 2015, time=2015-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1310598, encodeId=2b861310598ff, content=<a href='/topic/show?id=25dc1002255e' target=_blank style='color:#2F92EE;'>#预测因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100225, encryptionId=25dc1002255e, topicName=预测因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6105386, createdName=宋威, createdTime=Fri Mar 20 06:08:00 CST 2015, time=2015-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355978, encodeId=256413559e807, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Mar 20 06:08:00 CST 2015, time=2015-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481858, encodeId=007e1481858d8, content=<a href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Fri Mar 20 06:08:00 CST 2015, time=2015-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1525681, encodeId=32911525681e8, content=<a href='/topic/show?id=e96e489842a' target=_blank style='color:#2F92EE;'>#年轻患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48984, encryptionId=e96e489842a, topicName=年轻患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aab511654279, createdName=minzju5056, createdTime=Fri Mar 20 06:08:00 CST 2015, time=2015-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562303, encodeId=6a25156230384, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Fri Mar 20 06:08:00 CST 2015, time=2015-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=18473, encodeId=e0c7184e395, content=抽的不是烟啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=drhqh240, createdTime=Wed Mar 18 20:49:00 CST 2015, time=2015-03-18, status=1, ipAttribution=)]
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    2015-03-20 slcumt
  9. [GetPortalCommentsPageByObjectIdResponse(id=58619, encodeId=a4ab586191d, content=心梗年轻化,吸烟脱不了干系, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c8c11605398, createdName=kellerni, createdTime=Thu Jan 21 10:40:00 CST 2016, time=2016-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1645553, encodeId=65bb16455533d, content=<a href='/topic/show?id=79d99e04630' target=_blank style='color:#2F92EE;'>#长期预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97046, encryptionId=79d99e04630, topicName=长期预后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0e4823226485, createdName=ymljack, createdTime=Fri Apr 17 17:08:00 CST 2015, time=2015-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=18577, encodeId=eeda185e771, content=燃烧的是生命哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Fri Mar 20 23:29:00 CST 2015, time=2015-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1310598, encodeId=2b861310598ff, content=<a href='/topic/show?id=25dc1002255e' target=_blank style='color:#2F92EE;'>#预测因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100225, encryptionId=25dc1002255e, topicName=预测因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6105386, createdName=宋威, createdTime=Fri Mar 20 06:08:00 CST 2015, time=2015-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1355978, encodeId=256413559e807, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Mar 20 06:08:00 CST 2015, time=2015-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481858, encodeId=007e1481858d8, content=<a href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Fri Mar 20 06:08:00 CST 2015, time=2015-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1525681, encodeId=32911525681e8, content=<a href='/topic/show?id=e96e489842a' target=_blank style='color:#2F92EE;'>#年轻患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48984, encryptionId=e96e489842a, topicName=年轻患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aab511654279, createdName=minzju5056, createdTime=Fri Mar 20 06:08:00 CST 2015, time=2015-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562303, encodeId=6a25156230384, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Fri Mar 20 06:08:00 CST 2015, time=2015-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=18473, encodeId=e0c7184e395, content=抽的不是烟啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=drhqh240, createdTime=Wed Mar 18 20:49:00 CST 2015, time=2015-03-18, status=1, ipAttribution=)]
    2015-03-18 drhqh240

    抽的不是烟啊

    0

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