如何预测急性硬膜下血肿患者的癫痫发生率?

2017-02-22 冯亮 中华医学网

癫痫临床发作或亚临床发作是急性硬膜下血肿(acute subdural hematoma,aSDH)患者的较为常见的并发症。然而,目前关于癫痫与aSDH关系的研究却少之又少。来自德国法兰克福歌德大学的Sae-Yeon Won等开展了一项回顾性临床研究,旨在探究aSDH患者癫痫的发生率和预测因子,并制定一个评分系统以指导预防性抗癫痫药物的使用,结果发表在2017年2月14日的World Neuros

癫痫临床发作或亚临床发作是急性硬膜下血肿(acute subdural hematoma,aSDH)患者的较为常见的并发症。然而,目前关于癫痫与aSDH关系的研究却少之又少。来自德国法兰克福歌德大学的Sae-Yeon Won等开展了一项回顾性临床研究,旨在探究aSDH患者癫痫的发生率和预测因子,并制定一个评分系统以指导预防性抗癫痫药物的使用,结果发表在2017年2月14日的World Neurosurgery在线。

回顾性分析作者所在单位2007-2015年所收治的年龄大于18岁的aSDH患者,记录并分析患者入院时年龄、性别、手术时间(发病至手术)、受伤原因、血肿部位(左侧、右侧或双侧)、血肿体积、中线移位情况、血肿厚度、入院时GCS评分、治疗方式(开颅去骨瓣、开颅但不去骨瓣、钻孔引流或保守治疗)、术后第24小时GCS评分、出院时GCS评分、术前和术后有无癫痫发作、脑电图痫样放电情况、卒中史、癫痫史、抗凝治疗史、再出血、出院时和第3个月时的GOS评分。通过多变量logistic回归分析探索发生癫痫的危险因素并制定一个评分系统。

最终,139例患者符合纳入标准,平均年龄为72.7±14.3岁,其中女性45人,男性96人,平均血肿体积96.6±51.5 ml,中线移位9.0±6.1 mm,88例(63.3%)患者接受了抗凝治疗。

53例(38.1%)患者发生了癫痫,其中21例(39.6%)为术前发生,34例(64.2%)为术后发生,2例(3.8%)术前术后都有发作。发生癫痫的独立危险因素为术后第24小时GCS评分<9分(OR值3.3),发病24小时后手术(OR 值2.0),接受抗凝治疗(OR值2.0)。发生癫痫的患者出院时和第3个月时功能预后更差(P=0.002)。此外,作者根据GSC评分、是否接受抗凝治疗和手术时间为发病24小时后制定了一套评分系统,小于24分者需使用预防性抗癫痫治疗。

表:GATE-24评分

综上所述,癫痫影响aSDH患者预后,因此,根据GATE-24评分系统,对于存在癫痫高风险的患者需使用预防性抗癫痫治疗。

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    2017-02-23 飛歌

    这个有点帮助,不错

    0