J Periodontal:肥胖与牙周炎密切相关,但存在性别特异性

2019-07-27 不详 网络

相比之下,女性的牙周较男性更健康,但全身性炎症标志物的水平表现较高。本研究旨在评估这种悖论是否可以通过肥胖或体形的不同分层来解释。在来自波美拉尼亚健康研究的3,268名受试者中,我们确定了牙周参数,C-反应蛋白(CRP)和纤维蛋白原作为炎症的标志物。行为和环境风险因素以及手握力被评估为干扰相关结果的因素。我们评估了肥胖特征和牙周变量的性别特异性关联,例如探诊深度(PD)与CRP和纤维蛋白原。结果显

相比之下,女性的牙周较男性更健康,但全身性炎症标志物的水平表现较高。本研究旨在评估这种悖论是否可以通过肥胖或体形的不同分层来解释。

在来自波美拉尼亚健康研究的3,268名受试者中,我们确定了牙周参数,C-反应蛋白(CRP)和纤维蛋白原作为炎症的标志物。行为和环境风险因素以及手握力被评估为干扰相关结果的因素。我们评估了肥胖特征和牙周变量的性别特异性关联,例如探诊深度(PD)与CRP和纤维蛋白原。

结果显示,校正了年龄,腰臀比(WHR),糖化血红蛋白,吸烟,教育和握力,确定了牙周炎和肥胖对CRP水平的异性作用。男性和女性的WHR和BMI与CRP相关(p <0.001)。CRP与男性PD相关(p = 0.001),但与女性无关(p = 0.11)。当校正体重指数(BMI)时,这种关联在男性中减少了15%(p = 0.002),但在女性中减少了70%(p = 0.58)。PD与男性和女性(p = 0.026)和男性(p = 0.002)中的菌斑和探查出血有关(p <0.001)。BMI减弱了女性的这种关联,但男性却没有。HbA1c对女性的PD有明显影响(p = 0.013),但对男性没有(p = 0.76)。

总之,该研究结果表明,全身CRP浓度受男性牙周炎和肥胖的影响。女性肥胖比男性更重要,超越了牙周参数的影响。

原始出处:

Meisel P, Eremenko M, et al., The Sex paradox in the interplay between periodontitis, obesity, and serum C-reactive protein. data from a general population. J Periodontol. 2019 Jul 25. doi: 10.1002/JPER.18-0733.

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