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Nature Medicine：Notch信号通路控制CD4阳性记忆T细胞的存活

2015-01-19 佚名 生物谷

T细胞Notch信号通路
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为了保护机体免于遭受将来相同的病原体感染，CD4阳性T细胞能分化成记忆T细胞。于此相对的，还有一群名为自主活化的CD4阳性记忆T细胞会持续存在于组织中造成对身体的破坏。然而机体如何控制CD4阳性记忆T细胞种群稳定的详细机制还不清楚。 本文的研究者们发现Notch信号通路中的一个蛋白Rbpj（recombination signal biding protein for immunoglobuli

为了保护机体免于遭受将来相同的病原体感染，CD4阳性T细胞能分化成记忆T细胞。于此相对的，还有一群名为自主活化的CD4阳性记忆T细胞会持续存在于组织中造成对身体的破坏。然而机体如何控制CD4阳性记忆T细胞种群稳定的详细机制还不清楚。

本文的研究者们发现Notch信号通路中的一个蛋白Rbpj（recombination signal biding protein for immunoglobulin k J region）受损后CD4阳性记忆T细胞的生存能力也受到遏制。对小鼠使用Notch信号通路的抑制剂也能减少CD4阳性记忆T细胞的种群数量，并能够预防实验性自身免疫型脑脊髓炎的复发。Pbpj缺陷的CD4阳性记忆T细胞表现出葡萄糖摄取减少，而背后的分子机制是由于Akt磷酸化的降低导致葡萄糖转运蛋白Glut1低表达造成的。

而通过给予Pbpj敲除小鼠丙酮酸（能够绕过葡萄糖摄取而作为底物直接供给三羧酸循环），可以抑制自助活化的CD4阳性记忆T细胞，说明CD4阳性记忆T细胞的存活依赖于葡萄糖代谢。

总的来说，文章阐释了Notch信号通路通过调节葡萄糖摄取来维持CD4阳性记忆T细胞的功能。

原始出处

Yoichi Maekawa, Chieko Ishifune, Shin-ichi Tsukumo, Katsuto Hozumi, Hideo Yagita & Koji Yasutomo.Notch controls the survival of memory CD4+ T cells by regulating glucose uptake.Nature Medicine.2014

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    2015-05-13 qidongfanjian

    #CD4#

    0

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    2015-05-02 liye789132251

    #Nat#

    0

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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577416, encodeId=1b4215e741638, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Wed Jan 21 00:19:00 CST 2015, time=2015-01-21, status=1, ipAttribution=)]
    2015-07-03 xinmeili

    #Notch信号#

    0

  4. 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createdName=liye789132251, createdTime=Sat May 02 10:19:00 CST 2015, time=2015-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2068306, encodeId=1adf2068306f5, content=<a href='/topic/show?id=90b8129e7bd' target=_blank style='color:#2F92EE;'>#Notch信号#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12977, encryptionId=90b8129e7bd, topicName=Notch信号)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Fri Jul 03 02:19:00 CST 2015, time=2015-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1858597, encodeId=1b77185859e2c, content=<a href='/topic/show?id=e0a9593596' target=_blank style='color:#2F92EE;'>#DIC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5935, encryptionId=e0a9593596, topicName=DIC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Fri Oct 02 19:19:00 CST 2015, time=2015-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1773475, encodeId=58631e7347573, content=<a href='/topic/show?id=5f014e1852' target=_blank style='color:#2F92EE;'>#CIN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4718, encryptionId=5f014e1852, topicName=CIN)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a9a038523631, createdName=kalseyzl, createdTime=Mon Dec 21 15:19:00 CST 2015, time=2015-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1373753, encodeId=a9e013e375305, content=<a href='/topic/show?id=eb3b129e01d' target=_blank style='color:#2F92EE;'>#Notch#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12970, encryptionId=eb3b129e01d, topicName=Notch)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ece5364, createdName=karmond, createdTime=Wed Jan 21 00:19:00 CST 2015, time=2015-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1412304, encodeId=239f14123040e, content=<a href='/topic/show?id=0c31129e85f' target=_blank style='color:#2F92EE;'>#Notch信号通路#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12978, encryptionId=0c31129e85f, topicName=Notch信号通路)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3c472859403, createdName=gracezdd, createdTime=Wed Jan 21 00:19:00 CST 2015, time=2015-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1487435, encodeId=c922148e4354a, content=<a href='/topic/show?id=ba951352387' target=_blank style='color:#2F92EE;'>#OTC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13523, encryptionId=ba951352387, topicName=OTC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b36f8313624, createdName=ymljack, createdTime=Wed Jan 21 00:19:00 CST 2015, time=2015-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1539579, encodeId=5eec15395e9a8, content=<a href='/topic/show?id=c61a2e315da' target=_blank style='color:#2F92EE;'>#信号通路#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27315, encryptionId=c61a2e315da, topicName=信号通路)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b12d13147749, createdName=wgx310, createdTime=Wed Jan 21 00:19:00 CST 2015, time=2015-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577416, encodeId=1b4215e741638, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Wed Jan 21 00:19:00 CST 2015, time=2015-01-21, status=1, ipAttribution=)]
    2015-10-02 jeanqiuqiu

    #DIC#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1864207, encodeId=df46186420ed0, content=<a href='/topic/show?id=f930432538' target=_blank style='color:#2F92EE;'>#CD4#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4325, encryptionId=f930432538, topicName=CD4)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b09892, createdName=qidongfanjian, createdTime=Wed May 13 17:19:00 CST 2015, time=2015-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1880461, encodeId=5d2d1880461ee, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Sat May 02 10:19:00 CST 2015, time=2015-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2068306, encodeId=1adf2068306f5, content=<a href='/topic/show?id=90b8129e7bd' target=_blank style='color:#2F92EE;'>#Notch信号#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12977, encryptionId=90b8129e7bd, topicName=Notch信号)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Fri Jul 03 02:19:00 CST 2015, time=2015-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1858597, encodeId=1b77185859e2c, content=<a href='/topic/show?id=e0a9593596' target=_blank style='color:#2F92EE;'>#DIC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5935, 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channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12970, encryptionId=eb3b129e01d, topicName=Notch)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ece5364, createdName=karmond, createdTime=Wed Jan 21 00:19:00 CST 2015, time=2015-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1412304, encodeId=239f14123040e, content=<a href='/topic/show?id=0c31129e85f' target=_blank style='color:#2F92EE;'>#Notch信号通路#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12978, encryptionId=0c31129e85f, topicName=Notch信号通路)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3c472859403, createdName=gracezdd, createdTime=Wed Jan 21 00:19:00 CST 2015, time=2015-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1487435, encodeId=c922148e4354a, content=<a href='/topic/show?id=ba951352387' target=_blank style='color:#2F92EE;'>#OTC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13523, encryptionId=ba951352387, topicName=OTC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b36f8313624, createdName=ymljack, createdTime=Wed Jan 21 00:19:00 CST 2015, time=2015-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1539579, encodeId=5eec15395e9a8, content=<a href='/topic/show?id=c61a2e315da' target=_blank style='color:#2F92EE;'>#信号通路#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27315, encryptionId=c61a2e315da, topicName=信号通路)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b12d13147749, createdName=wgx310, createdTime=Wed Jan 21 00:19:00 CST 2015, time=2015-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577416, encodeId=1b4215e741638, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Wed Jan 21 00:19:00 CST 2015, time=2015-01-21, status=1, ipAttribution=)]
    2015-12-21 kalseyzl

    #CIN#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1864207, encodeId=df46186420ed0, content=<a href='/topic/show?id=f930432538' target=_blank style='color:#2F92EE;'>#CD4#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4325, encryptionId=f930432538, topicName=CD4)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b09892, createdName=qidongfanjian, createdTime=Wed May 13 17:19:00 CST 2015, time=2015-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1880461, encodeId=5d2d1880461ee, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, 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encryptionId=e0a9593596, topicName=DIC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Fri Oct 02 19:19:00 CST 2015, time=2015-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1773475, encodeId=58631e7347573, content=<a href='/topic/show?id=5f014e1852' target=_blank style='color:#2F92EE;'>#CIN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4718, encryptionId=5f014e1852, topicName=CIN)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a9a038523631, createdName=kalseyzl, createdTime=Mon Dec 21 15:19:00 CST 2015, time=2015-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1373753, encodeId=a9e013e375305, content=<a href='/topic/show?id=eb3b129e01d' target=_blank style='color:#2F92EE;'>#Notch#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12970, encryptionId=eb3b129e01d, topicName=Notch)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ece5364, createdName=karmond, createdTime=Wed Jan 21 00:19:00 CST 2015, time=2015-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1412304, encodeId=239f14123040e, content=<a href='/topic/show?id=0c31129e85f' target=_blank style='color:#2F92EE;'>#Notch信号通路#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12978, encryptionId=0c31129e85f, topicName=Notch信号通路)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3c472859403, createdName=gracezdd, createdTime=Wed Jan 21 00:19:00 CST 2015, time=2015-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1487435, encodeId=c922148e4354a, content=<a href='/topic/show?id=ba951352387' target=_blank style='color:#2F92EE;'>#OTC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13523, encryptionId=ba951352387, topicName=OTC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b36f8313624, createdName=ymljack, createdTime=Wed Jan 21 00:19:00 CST 2015, time=2015-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1539579, encodeId=5eec15395e9a8, content=<a href='/topic/show?id=c61a2e315da' target=_blank style='color:#2F92EE;'>#信号通路#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27315, encryptionId=c61a2e315da, topicName=信号通路)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b12d13147749, createdName=wgx310, createdTime=Wed Jan 21 00:19:00 CST 2015, time=2015-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577416, encodeId=1b4215e741638, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Wed Jan 21 00:19:00 CST 2015, time=2015-01-21, status=1, ipAttribution=)]
    2015-01-21 karmond

    #Notch#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1864207, encodeId=df46186420ed0, content=<a href='/topic/show?id=f930432538' target=_blank style='color:#2F92EE;'>#CD4#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4325, encryptionId=f930432538, topicName=CD4)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b09892, createdName=qidongfanjian, createdTime=Wed May 13 17:19:00 CST 2015, time=2015-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1880461, encodeId=5d2d1880461ee, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, 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encryptionId=e0a9593596, topicName=DIC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Fri Oct 02 19:19:00 CST 2015, time=2015-10-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1773475, encodeId=58631e7347573, content=<a href='/topic/show?id=5f014e1852' target=_blank style='color:#2F92EE;'>#CIN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4718, encryptionId=5f014e1852, topicName=CIN)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a9a038523631, createdName=kalseyzl, createdTime=Mon Dec 21 15:19:00 CST 2015, time=2015-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1373753, encodeId=a9e013e375305, content=<a href='/topic/show?id=eb3b129e01d' target=_blank style='color:#2F92EE;'>#Notch#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12970, encryptionId=eb3b129e01d, topicName=Notch)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ece5364, createdName=karmond, createdTime=Wed Jan 21 00:19:00 CST 2015, time=2015-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1412304, encodeId=239f14123040e, content=<a href='/topic/show?id=0c31129e85f' target=_blank style='color:#2F92EE;'>#Notch信号通路#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12978, encryptionId=0c31129e85f, topicName=Notch信号通路)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3c472859403, createdName=gracezdd, createdTime=Wed Jan 21 00:19:00 CST 2015, time=2015-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1487435, encodeId=c922148e4354a, content=<a href='/topic/show?id=ba951352387' target=_blank style='color:#2F92EE;'>#OTC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13523, encryptionId=ba951352387, topicName=OTC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b36f8313624, createdName=ymljack, createdTime=Wed Jan 21 00:19:00 CST 2015, time=2015-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1539579, encodeId=5eec15395e9a8, content=<a href='/topic/show?id=c61a2e315da' target=_blank style='color:#2F92EE;'>#信号通路#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27315, encryptionId=c61a2e315da, topicName=信号通路)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b12d13147749, createdName=wgx310, createdTime=Wed Jan 21 00:19:00 CST 2015, time=2015-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577416, encodeId=1b4215e741638, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Wed Jan 21 00:19:00 CST 2015, time=2015-01-21, status=1, ipAttribution=)]
    2015-01-21 gracezdd

    #Notch信号通路#

    0

  8. 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channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12970, encryptionId=eb3b129e01d, topicName=Notch)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ece5364, createdName=karmond, createdTime=Wed Jan 21 00:19:00 CST 2015, time=2015-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1412304, encodeId=239f14123040e, content=<a href='/topic/show?id=0c31129e85f' target=_blank style='color:#2F92EE;'>#Notch信号通路#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12978, encryptionId=0c31129e85f, topicName=Notch信号通路)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3c472859403, createdName=gracezdd, createdTime=Wed Jan 21 00:19:00 CST 2015, time=2015-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1487435, encodeId=c922148e4354a, content=<a href='/topic/show?id=ba951352387' target=_blank style='color:#2F92EE;'>#OTC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13523, encryptionId=ba951352387, topicName=OTC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b36f8313624, createdName=ymljack, createdTime=Wed Jan 21 00:19:00 CST 2015, time=2015-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1539579, encodeId=5eec15395e9a8, content=<a href='/topic/show?id=c61a2e315da' target=_blank style='color:#2F92EE;'>#信号通路#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27315, encryptionId=c61a2e315da, topicName=信号通路)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b12d13147749, createdName=wgx310, createdTime=Wed Jan 21 00:19:00 CST 2015, time=2015-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577416, encodeId=1b4215e741638, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Wed Jan 21 00:19:00 CST 2015, time=2015-01-21, status=1, ipAttribution=)]
    2015-01-21 ymljack

    #OTC#

    0

  9. 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channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12970, encryptionId=eb3b129e01d, topicName=Notch)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ece5364, createdName=karmond, createdTime=Wed Jan 21 00:19:00 CST 2015, time=2015-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1412304, encodeId=239f14123040e, content=<a href='/topic/show?id=0c31129e85f' target=_blank style='color:#2F92EE;'>#Notch信号通路#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12978, encryptionId=0c31129e85f, topicName=Notch信号通路)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3c472859403, createdName=gracezdd, createdTime=Wed Jan 21 00:19:00 CST 2015, time=2015-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1487435, encodeId=c922148e4354a, content=<a href='/topic/show?id=ba951352387' target=_blank style='color:#2F92EE;'>#OTC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13523, encryptionId=ba951352387, topicName=OTC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b36f8313624, createdName=ymljack, createdTime=Wed Jan 21 00:19:00 CST 2015, time=2015-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1539579, encodeId=5eec15395e9a8, content=<a href='/topic/show?id=c61a2e315da' target=_blank style='color:#2F92EE;'>#信号通路#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27315, encryptionId=c61a2e315da, topicName=信号通路)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b12d13147749, createdName=wgx310, createdTime=Wed Jan 21 00:19:00 CST 2015, time=2015-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577416, encodeId=1b4215e741638, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Wed Jan 21 00:19:00 CST 2015, time=2015-01-21, status=1, ipAttribution=)]
    2015-01-21 wgx310

    #信号通路#

    0

  10. 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channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12970, encryptionId=eb3b129e01d, topicName=Notch)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ece5364, createdName=karmond, createdTime=Wed Jan 21 00:19:00 CST 2015, time=2015-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1412304, encodeId=239f14123040e, content=<a href='/topic/show?id=0c31129e85f' target=_blank style='color:#2F92EE;'>#Notch信号通路#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12978, encryptionId=0c31129e85f, topicName=Notch信号通路)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3c472859403, createdName=gracezdd, createdTime=Wed Jan 21 00:19:00 CST 2015, time=2015-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1487435, encodeId=c922148e4354a, content=<a href='/topic/show?id=ba951352387' target=_blank style='color:#2F92EE;'>#OTC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13523, encryptionId=ba951352387, topicName=OTC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b36f8313624, createdName=ymljack, createdTime=Wed Jan 21 00:19:00 CST 2015, time=2015-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1539579, encodeId=5eec15395e9a8, content=<a href='/topic/show?id=c61a2e315da' target=_blank style='color:#2F92EE;'>#信号通路#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27315, encryptionId=c61a2e315da, topicName=信号通路)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b12d13147749, createdName=wgx310, createdTime=Wed Jan 21 00:19:00 CST 2015, time=2015-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577416, encodeId=1b4215e741638, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Wed Jan 21 00:19:00 CST 2015, time=2015-01-21, status=1, ipAttribution=)]
    2015-01-21 ms1692212821629096

    #Medicine#

    0

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当免疫学家Michel Sadelain在2007年推出他的第一个由基因工程技术改造的抗癌T细胞试验时，很难找到愿意参与的病人。当时的小鼠研究表明，从患者体内分离出的T细胞经过基因工程改造后，再输回患者体内能够对癌细胞发挥作用。 当时，同行们都不支持在病人身上使用这种听起来像科幻小说一样的疗法。不过，Sadelain并不责怪他们；因为在他自己看来，这也是非常疯狂的。然而，经过了几年的

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目前治疗HIV/AIDS的主要屏障就是在慢性感染患者机体细胞中存在隐藏的HIV，近日，一项发表于国际杂志Nature上的研究论文中，来自耶鲁大学等处的研究人员开发出了一种可有效清除残留病毒的新型策略。 尽管目前可以用抗逆转录病毒疗法来治疗HIV的感染，但是在患者机体中仍然存在大量潜伏的HIV，文章中研究者就提出疑问，是否杀伤T细胞可以被刺激用来有效靶向作用并杀灭包含休眠病毒的免疫细胞，相关研

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