STEM CELLS:增压干细胞创建新疗法

2015-07-08 佚名 生物谷

近日,发表在国际期刊Stem Cells上的一项研究指出,阿德莱德大学的研究人员发现了一种培养干细胞的新方法,该方法可使细胞生长的更快,更强壮。 Kisha Sivanathan博士说这在干细胞上是一个激动人心的突破性研究。“成人间充质干细胞可以从体内许多组织包括骨髓中获得,这种干细胞吸引着世界各地的科学家,因为它们易于培养、源于天然、治疗效果好。这些干细胞用于治疗许多种炎性疾病,研究人员一直在

近日,发表在国际期刊Stem Cells上的一项研究指出,阿德莱德大学的研究人员发现了一种培养干细胞的新方法,该方法可使细胞生长的更快,更强壮。

Kisha Sivanathan博士说这在干细胞上是一个激动人心的突破性研究。“成人间充质干细胞可以从体内许多组织包括骨髓中获得,这种干细胞吸引着世界各地的科学家,因为它们易于培养、源于天然、治疗效果好。这些干细胞用于治疗许多种炎性疾病,研究人员一直在寻找提高干细胞能效的方法。”Sivanathan博士说。

“我们的研究小组在世界上首次观察了间充质干细胞和IL-17之间的交互作用,在重度炎症期间(如在移植排斥反应)一种强效的蛋白质在体内自然发生。我们发现,经IL-17处理的间充质干细胞的生长速度是未经处理的干细胞生长速度的两倍,而且在调节人体的免疫反应时更有效。”她说。

干细胞疗法对移植患者显示出可喜的迹象,Sivanathan博士说,经IL-17处理的干细胞应该对移植受者预防和治疗炎症反应更有效,尤其是对受移植患者产生的排斥反应可以控制。

“当前药物(免疫抑制剂药物)用来帮助病人防止移植排斥而抑制整个免疫系统,但会产生严重副作用,如癌症。然而,当体内正在修复受损组织时干细胞疗法(用免疫抑制剂药物结合使用)会帮助病人“接受”移植体,从而会引起较少的副作用,”Sivanathan说。

“对于经IL-17处理的干细胞疗法我们还尚未进行临床试验,但我们预计这种会产生更多干细胞的疗法比未经处理的干细胞将会更加有前景。"她说。

原始出处:

Kisha Nandini Sivanathan1,2,4, Darling M. Rojas-Canales1,4, Christopher M. Hope1,4, Ravi Krishnan1, Robert P. Carroll4,5, Stan Gronthos2,3, Shane T. Grey6,* andPatrick T. Coates1,2,4,5,*.Interleukin-17A-Induced Human Mesenchymal Stem Cells Are Superior Modulators of Immunological Function.Stem Cell.June 23, 2015.

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    2016-03-09 智智灵药
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  6. [GetPortalCommentsPageByObjectIdResponse(id=1794846, encodeId=12631e94846dc, content=<a href='/topic/show?id=46e716e82a6' target=_blank style='color:#2F92EE;'>#stem cells#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16782, encryptionId=46e716e82a6, topicName=stem cells)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3883266, createdName=yykkxiaodou, createdTime=Thu Dec 31 01:09:00 CST 2015, time=2015-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1869157, encodeId=7163186915e4b, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Fri Apr 29 00:09:00 CST 2016, time=2016-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959411, encodeId=7735195941188, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Wed Mar 09 15:09:00 CST 2016, time=2016-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1794391, encodeId=0ab71e9439147, content=<a href='/topic/show?id=82b416e79f5' target=_blank style='color:#2F92EE;'>#stem cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16779, encryptionId=82b416e79f5, topicName=stem cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Mon Sep 28 07:09:00 CST 2015, time=2015-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481874, encodeId=467614818e41b, content=<a href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Fri Jul 10 00:09:00 CST 2015, time=2015-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1554452, encodeId=eb93155445295, content=<a href='/topic/show?id=74e458559f5' target=_blank style='color:#2F92EE;'>#新疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58559, encryptionId=74e458559f5, topicName=新疗法)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d03114536414, createdName=kcb074, createdTime=Fri Jul 10 00:09:00 CST 2015, time=2015-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614914, encodeId=59671614914ff, content=<a href='/topic/show?id=d74a44e2e7' target=_blank style='color:#2F92EE;'>#cells#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4472, encryptionId=d74a44e2e7, topicName=cells)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=659819575782, createdName=124988c7m101暂无昵称, createdTime=Fri Jul 10 00:09:00 CST 2015, time=2015-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31562, encodeId=7e363156231, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Wed Jul 08 12:09:00 CST 2015, time=2015-07-08, status=1, ipAttribution=)]
    2015-07-10 kcb074
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  8. [GetPortalCommentsPageByObjectIdResponse(id=1794846, encodeId=12631e94846dc, content=<a href='/topic/show?id=46e716e82a6' target=_blank style='color:#2F92EE;'>#stem cells#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16782, encryptionId=46e716e82a6, topicName=stem cells)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3883266, createdName=yykkxiaodou, createdTime=Thu Dec 31 01:09:00 CST 2015, time=2015-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1869157, encodeId=7163186915e4b, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Fri Apr 29 00:09:00 CST 2016, time=2016-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959411, encodeId=7735195941188, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Wed Mar 09 15:09:00 CST 2016, time=2016-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1794391, encodeId=0ab71e9439147, content=<a href='/topic/show?id=82b416e79f5' target=_blank style='color:#2F92EE;'>#stem cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16779, encryptionId=82b416e79f5, topicName=stem cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Mon Sep 28 07:09:00 CST 2015, time=2015-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1481874, encodeId=467614818e41b, content=<a href='/topic/show?id=8cc416e78f3' target=_blank style='color:#2F92EE;'>#STEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Fri Jul 10 00:09:00 CST 2015, time=2015-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1554452, encodeId=eb93155445295, content=<a href='/topic/show?id=74e458559f5' target=_blank style='color:#2F92EE;'>#新疗法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58559, encryptionId=74e458559f5, topicName=新疗法)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d03114536414, createdName=kcb074, createdTime=Fri Jul 10 00:09:00 CST 2015, time=2015-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614914, encodeId=59671614914ff, content=<a href='/topic/show?id=d74a44e2e7' target=_blank style='color:#2F92EE;'>#cells#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4472, encryptionId=d74a44e2e7, topicName=cells)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=659819575782, createdName=124988c7m101暂无昵称, createdTime=Fri Jul 10 00:09:00 CST 2015, time=2015-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31562, encodeId=7e363156231, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Wed Jul 08 12:09:00 CST 2015, time=2015-07-08, status=1, ipAttribution=)]
    2015-07-08 huaxipanxing

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ISSCR:国际干细胞研究学会年会发布两项重要成果

10多年来,干细胞疗法一直被认为能够给那些遭受遗传和退行性疾病折磨的人带来希望。而就在几天前,随着两个研究团队在于日本横滨召开的国际干细胞研究学会(ISSCR)年会上宣告了他们在人类临床研究中取得的成果——一项聚焦于罕见的遗传神经病,另一项则着眼于老年人的视力丧失,这一希望又朝着现实迈出了一步。 美国加利福尼亚州纽瓦克市干细胞公司报告了用人体神经干细胞治疗梅氏病(PMD)所取得的鼓舞人心的研究成

J Virol:干细胞疗法为治疗HIV感染另辟蹊径

近日,来自加利福尼亚大学戴维斯分校的研究者使用了一种创新的干细胞疗法来对抗引起AIDS的HIV病毒。研究者刊登在5月份的国际杂志Journal of Virology上的研究文章指出,安全有效的将抗HIV病毒的干细胞移植入小鼠体内可以描述病人感染的模型,这种新型技术是用一种携带有三倍结合的抗HIV的基因的工程干细胞来替代免疫系统,而且被证明是能够发挥正常功能的。 研究者Joseph Anders

Cell Transpl:干细胞疗法或可预防关节损伤后骨关节炎

近日,来自杜克大学的研究者发现了一种有潜力的干细胞疗法来预防关节损伤后的骨关节炎。 关节的损伤可产生称为创伤后关节炎(PTA)的骨关节炎,目前并没有有效的疗法来减缓或者治疗该病症。研究者通过研究发现了一种非常有前景的PTA治疗方法-干细胞疗法,这种干细胞称为间质干细胞(MSCs),这项研究发现将用于治疗关节损伤后的治疗。 研究者表示,干细胞可以通过改变膝关节炎症和再生之间的平衡来阻止关节炎的发

Stem Cell Rep:干细胞疗法或可靶向治疗骨关节炎

近日,发表在国际杂志Stem Cell Reports上的一篇研究论文中,来自约克大学的研究人员通过研究在开发治疗关节炎的新型疗法上取得了突破性的进展;文章中研究者鉴别出了可以进行组织、软骨及骨质再生的单一干细胞。 干细胞往往混合于人类的骨髓间质细胞(MSCs)中,但其在表象上却和MSCs非常相似,研究者一般很难将二者区分开来,这项研究中,研究者通过分离MSCs并且对其特性进行了分析,最终鉴

BMC Medicine:干细胞疗法有望治愈压力性尿失禁

压力性尿失禁(SUI)通常在打喷嚏、咳嗽、运动甚至大笑时等情况下发生,其发生的主要原因是因为盆底肌肉太弱,膀胱压力造成泄漏。一项新的发表在BMC Medicine的研究论文表明,一种使用从羊水中分离干细胞的新技术可以使得再生受损的尿道外括约肌的肌肉,以此来预防小鼠压力性尿失禁的发生。 SUI在怀孕期间以及怀孕之后、年龄在40岁后的妇女中比较常见,有三分之一的妇女在她们的生活中会经历SUI。男性也