Malar J:孕妇感染间日疟原虫会怎样?

2015-05-10 MedSci MedSci原创

疟疾是经按蚊叮咬或输入带疟原虫者的血液而感染疟原虫所引起的虫媒传染病。寄生于人体的疟原虫共有四种,即间日疟原虫,三日疟原虫,恶性疟原虫和卵形疟原虫。疟疾主要表 现为周期性规律发作,全身发冷、发热、多汗,长期多次发作后,可引起贫血和脾肿大。已有研究表明,怀孕期间女性体内恶性疟原虫诱发疟疾可能导致胎盘病变和宫内生长受限(IUGR)等不良妊娠结局。但是关于孕期间日疟原虫诱发疟疾的相关研究目前几乎还没有。

疟疾是经按蚊叮咬或输入带疟原虫者的血液而感染疟原虫所引起的虫媒传染病。寄生于人体的疟原虫共有四种,即间日疟原虫,三日疟原虫,恶性疟原虫和卵形疟原虫。疟疾主要表 现为周期性规律发作,全身发冷、发热、多汗,长期多次发作后,可引起贫血和脾肿大。

已有研究表明,怀孕期间女性体内恶性疟原虫诱发疟疾可能导致胎盘病变和宫内生长受限(IUGR)等不良妊娠结局。但是关于孕期间日疟原虫诱发疟疾的相关研究目前几乎还没有。因此Brock MF等人在西亚马逊州首府玛瑙斯市进行了一项研究,对一群间日疟原虫疟疾孕妇进行超声检查(B超是评估胎儿情况和胎盘功能的一种有效的方法),旨在调查该类特殊人群中胎盘厚度情况,胎儿生物统计学情况和羊水情况,以探究孕期间日疟原虫诱发疟疾对妊娠的影响。

该研究共纳入118名感染间日疟原虫孕妇,以及191名非疟疾孕妇作为对照。研究者通过B超检测获得胎儿、胎盘、羊水等相关数据。孕妇感染间日疟原虫后,每3个月测量胎儿的生物学指标并转换为z值。经过对两组间进行数据统计分析以得到结论。

研究结果显示,纳入的所有孕妇中,只在疟疾组B超发现10名孕妇的胎盘厚度增加(8.5 vs 0%; p <0.001)。无论是对对照组相比较,还是根据孕妇间日疟原虫感染时间,均没有发现胎儿B超检测下生物学指标的z值有任何差异。对118名感染间日疟原虫孕妇的超声检查提示,7(6%)名胎儿显示体重低,2(1.7%)名胎儿显示羊水过少和1(0.85%)名胎儿显示胎儿畸形。这些结果与对照组相比较,并没有发现统计学差异。

该研究结果虽然提示感染间日疟原虫孕妇的胎盘厚度会有增加,但是并没有对胎儿出生时产生不良影响。除了胎盘厚度,B超检查所提示的其他信息在两组间均没有发现显著差异。

原始出处:

Brock MF, Miranda AE, Botto-Menezes C, Leao JR, Martinez-Espinosa FE. Ultrasound findings in pregnant women with uncomplicated vivax malaria in the Brazilian Amazon: a cohort study. Malar J. 2015. 14(1): 144.

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    2017-03-01 superdove

    疟疾在孕妇上是个好的研究点

    0

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    2015-05-13 huaxipanxing

    看看

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    2015-05-11 lovejing

    对胎儿营养状况有干扰吗?出生体重会否有差异?

    0

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