Immunotherapy:哮喘及鼻炎患者中,IL-4, IL-31 和TLSP水平的意义

2017-04-07 AlexYang MedSci原创

最近,研究人员为了调查IL-4, IL-31 和胸腺基质淋巴细胞生成素(TLSP)水平在哮喘及鼻炎病人中的临床意义,在动物中进行了简单的查证。 研究人员利用ELISA技术和实时定量技术检测了IL-4, IL-31 和TLSP水平。病人群体为64位哮喘病人(sIgE[+]: 32 cases, sIgE[-]: 32 cases),64位鼻炎病人(sIgE[+]: 32 cases, sI

最近,研究人员为了调查IL-4, IL-31 和胸腺基质淋巴细胞生成素(TLSP)水平在哮喘及鼻炎病人中的临床意义,在动物中进行了简单的查证。

研究人员利用ELISA技术和实时定量技术检测了IL-4, IL-31 和TLSP水平。病人群体为64位哮喘病人(sIgE[+]: 32 cases, sIgE[-]: 32 cases),64位鼻炎病人(sIgE[+]: 32 cases, sIgE[-]: 32 cases),64位哮喘并发过敏性鼻炎病人(sIgE[+]: 32 cases, sIgE[-]: 32 cases)和32位健康对照。然后,研究人员还在致敏小鼠中检测了IL-4, IL-31 和TLSP水平。

研究结果展示了哮喘和鼻炎病人中IL-4, IL-31 和TLSP的水平,以及那些并发过敏性鼻炎的病人的IL-4, IL-31 和TLSP的水平。和对照组相比,IL-4, IL-31 和TLSP的水平具有显着的差异(p<0.05),并且在活体内实验中得到了同样的结论。

研究人员指出,IL-4, IL-31 和TLSP的水平也许参与了哮喘和鼻炎的发病机理。另外,尘螨和艾蒿过敏可以显着的提高IL-4, IL-31 和TLSP的水平。

原始出处:

Chai R, Liu B, Qi F. The significance of the levels of IL-4, IL-31 and TLSP in patients with asthma and/or rhinitis. Immunotherapy. March 2017. doi: 10.2217/imt-2016-0131

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    2017-08-19 仁心济世
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    2017-04-26 往日如昨

    学习了谢谢分享

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    2017-04-17 往日如昨

    学习了谢谢分享

    0

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    2017-04-08 wang_shengli

    讲的非常好非常棒

    0

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