CLIN CANCER RES：非霍奇金淋巴瘤和霍奇金淋巴瘤过表达BCLW

2017-11-30 MedSci MedSci原创

B细胞淋巴瘤在进展过程中必然会出现凋亡抵抗。最近的研究发现BCLW，一个抗凋亡BCL2家族成员，过去认为仅对精子生成过程有影响，在弥漫大B淋巴瘤和Burkitt淋巴瘤中过表达。CLIN CANCER RES近期发表了一篇文章，研究6种不同B细胞淋巴瘤BCLW和其他抗凋亡BCL2家族成员的表达，以进一步研究BCLW对B细胞淋巴瘤的作用以及其对BCL2抑制剂耐药的影响。

B细胞淋巴瘤在进展过程中必然会出现凋亡抵抗。最近的研究发现BCLW，一个抗凋亡BCL2家族成员，过去认为仅对精子生成过程有影响，在弥漫大B淋巴瘤和Burkitt淋巴瘤中过表达。CLIN CANCER RES近期发表了一篇文章，研究6种不同B细胞淋巴瘤BCLW和其他抗凋亡BCL2家族成员的表达，以进一步研究BCLW对B细胞淋巴瘤的作用以及其对BCL2抑制剂耐药的影响。

作者分析了约2300例患者标本的基因表达情况，包括非霍奇金和霍奇金淋巴瘤以及侵袭性强弱不同的淋巴瘤。使用qRT-PCR和免疫组化验证数据。研究结果表明在侵袭性强和侵袭弱的淋巴瘤中BCLW均显着过表达，包括弥漫大B细胞淋巴瘤，Burkitt，滤泡，套细胞和霍奇金淋巴瘤。值得注意的是，BCLW优先于BCL2过表达且在某些淋巴瘤中与BCL2负相关。在滤泡淋巴瘤中BCLW过表达频率与BCL2相同。在6类B细胞淋巴瘤中评估所有5种抗凋亡BCL2家族成员的结果表明BCL2，BCLW和BCLX持续过表达，而MCL1和A1不是。此外个体淋巴瘤经常出现超过1个BCL2家族成员过表达情况。

文章最后认为，B细胞淋巴瘤通常出现BCLW过表达联合或替代其他抗凋亡BCL2家族其他成员。在淋巴瘤生存过程中BCLW和BCL2可能具有同样重要的作用，应考虑靶向BCLW治疗淋巴瘤。

原始出处：

Clare M.Adams,Ramkrishna Mitra,et al.Non-Hodgkin and Hodgkin Lymphomas Select for Overexpression of BCLW.CLIN CANCER RES.November 2017 doi:10.1158/1078-0432.CCR-17-1144

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2018-05-19 lq1767

#过表达#

29 0
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2018-02-15 1e145228m78(暂无匿称)

学习了.谢谢作者分享!

73 0
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2017-11-30 1ddf0692m34(暂无匿称)

学习了.涨知识

77 0
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2017-11-30 xiaotao112411

学习学习学习

62 0
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2017-11-30 xiaotao112411

学习学习学习

82 0
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2017-11-30 xiaotao112411

学习学习学习

87 0
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2017-11-30 xiaotao112411

学习学习学习

20 0
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createdName=1e145228m78(暂无匿称), createdTime=Thu Feb 15 09:08:32 CST 2018, time=2018-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265705, encodeId=e00d265e0516, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Thu Nov 30 15:38:20 CST 2017, time=2017-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265670, encodeId=d0f82656e005, content= 学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Thu Nov 30 12:57:42 CST 2017, time=2017-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265669, encodeId=f32d2656693a, content= 学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Thu Nov 30 12:57:30 CST 2017, time=2017-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265668, encodeId=49d126566850, content= 学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Thu Nov 30 12:57:19 CST 2017, time=2017-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265665, encodeId=f85f265665b9, content= 学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Thu Nov 30 12:57:15 CST 2017, time=2017-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265664, encodeId=6f63265664c4, content= 学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Thu Nov 30 12:57:10 CST 2017, time=2017-11-30, status=1, ipAttribution=)]
2017-11-30 xiaotao112411

学习学习学习

18 0
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createdName=1e145228m78(暂无匿称), createdTime=Thu Feb 15 09:08:32 CST 2018, time=2018-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265705, encodeId=e00d265e0516, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Thu Nov 30 15:38:20 CST 2017, time=2017-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265670, encodeId=d0f82656e005, content= 学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Thu Nov 30 12:57:42 CST 2017, time=2017-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265669, encodeId=f32d2656693a, content= 学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Thu Nov 30 12:57:30 CST 2017, time=2017-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265668, encodeId=49d126566850, content= 学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Thu Nov 30 12:57:27 CST 2017, time=2017-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265667, encodeId=985126566ead, content= 学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Thu Nov 30 12:57:23 CST 2017, time=2017-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265666, encodeId=d5fa26566646, content= 学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Thu Nov 30 12:57:19 CST 2017, time=2017-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265665, encodeId=f85f265665b9, content= 学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Thu Nov 30 12:57:15 CST 2017, time=2017-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265664, encodeId=6f63265664c4, content= 学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Thu Nov 30 12:57:10 CST 2017, time=2017-11-30, status=1, ipAttribution=)]
2017-11-30 xiaotao112411

学习学习学习

20 0
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createdName=1e145228m78(暂无匿称), createdTime=Thu Feb 15 09:08:32 CST 2018, time=2018-02-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265705, encodeId=e00d265e0516, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Thu Nov 30 15:38:20 CST 2017, time=2017-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265670, encodeId=d0f82656e005, content= 学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Thu Nov 30 12:57:19 CST 2017, time=2017-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265665, encodeId=f85f265665b9, content= 学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Thu Nov 30 12:57:15 CST 2017, time=2017-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=265664, encodeId=6f63265664c4, content= 学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/05/dc628308c49d4aa82335673176ebb6d3.jpg, createdBy=153c1955083, createdName=xiaotao112411, createdTime=Thu Nov 30 12:57:10 CST 2017, time=2017-11-30, status=1, ipAttribution=)]
2017-11-30 xiaotao112411

学习学习学习

17 0

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