Arthritis Rheumatol:肥胖、肌肉减少性肥胖和少肌症的膝部骨关节炎风险

2018-08-15 xiangting MedSci原创

在这个大型纵向队列中,基于身体成分的肥胖和肌肉减少性肥胖与膝部OA风险相关,而不是少肌症。

由身体测量学定义的肥胖是众所周知的膝部骨关节炎(OA)危险因素,但是关于身体成分(脂肪和肌肉质量)与膝部OA风险关联的数据相对较少。这项研究分析了基于脂肪和肌肉质量的身体成分类别与偶发性膝部OA风险之间的纵向关联。

纳入来自多中心骨关节炎(MOST)研究的参与者,这是一个膝关节OA患者或危险个体的纵向队列。根据全身双能X线(DXA)的身体成分(即脂肪和肌肉质量),受试者被分类为:1)肥胖;2)肌肉减少性肥胖;3)少肌症;4)非肌肉性非肥胖者。调整潜在混杂因素后,使用有效方差估计的二项式回归,分析了基线身体成分类别与60个月时影像学OA风险之间的关联。

基线时无影像学膝关节OA的1653名受试者中,肥胖(女性RR 2.29,95%CI 1.64-3.20;男性RR 1.73,95%CI 1.08-2.78)和肌肉减少性肥胖女性( RR 1.91,95%CI 1.17-3.11)发生偶发性影像学膝关节OA的风险显著增加,而男性无升高(RR 1.74,95%CI 0.68-4.46)。少肌症与膝部OA风险无关(女性RR 0.96,95%CI 0.62-1.49;男性RR 0.66;95%CI 0.34-1.30)。

研究发现在这个大型纵向队列中,基于身体成分的肥胖和肌肉减少性肥胖与膝部OA风险相关,而不是少肌症。膝部OA的减重策略应该集中在肥胖和肌肉减少性肥胖上。

原始出处:
Devyani Misra, et al. Risk of knee oa with obesity, sarcopenic obesity and sarcopenia. Arthritis Rheumatol. 14 August 2018.

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    2019-01-23 lisa438
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    2018-08-17 lmm397
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    2018-08-17 zhaojie88
  6. [GetPortalCommentsPageByObjectIdResponse(id=1972520, encodeId=781519e25203e, content=<a href='/topic/show?id=8a6a2e8839' target=_blank style='color:#2F92EE;'>#Arthritis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2788, encryptionId=8a6a2e8839, topicName=Arthritis)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIibticIBly5jCSic5ZElW4He3rO4DMpUHUFaFX57OicNMnzckWaicBNeStwugWHFCuOdicoakApM4HGmtw/132, createdBy=f8672500006, createdName=ms6390871039024434, createdTime=Wed Jun 12 06:37:00 CST 2019, time=2019-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1647090, encodeId=3d77164e090fb, content=<a href='/topic/show?id=fd6d809e535' target=_blank style='color:#2F92EE;'>#肌肉减少#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80975, encryptionId=fd6d809e535, topicName=肌肉减少)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d18723374958, createdName=shizhenshan, createdTime=Thu Feb 07 06:37:00 CST 2019, time=2019-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2026583, encodeId=166a2026583a5, content=<a href='/topic/show?id=e0b110159578' target=_blank style='color:#2F92EE;'>#骨关节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101595, encryptionId=e0b110159578, topicName=骨关节)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373b263, createdName=lisa438, createdTime=Wed Jan 23 17:37:00 CST 2019, time=2019-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1265777, encodeId=f9511265e77c7, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Fri Aug 17 01:37:00 CST 2018, time=2018-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356891, encodeId=e311135689122, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Aug 17 01:37:00 CST 2018, time=2018-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=338739, encodeId=4b77338e39de, content=好文,值得点赞!认真学习了,把经验应用于实践,为患者解除病痛。, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30251637888, createdName=lietome15, createdTime=Wed Aug 15 10:51:04 CST 2018, time=2018-08-15, status=1, ipAttribution=)]
    2018-08-15 lietome15

    好文,值得点赞!认真学习了,把经验应用于实践,为患者解除病痛。

    0

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