食物上瘾?试试莫达非尼

2016-12-29 MedSci MedSci原创

近日,来自英国华威大学的商学院的一项新的研究发现表明,用于治疗发作性睡病等睡眠障碍处方药——莫达非尼,有助于治疗因食物上瘾而导致肥胖的人群,该研究结果已发表于Personality and Individual Differences。 莫达非尼是一种促醒剂用于治疗因发作性睡病、阻塞性睡眠呼吸暂停和轮班工作障碍所致的嗜睡。虽然目前尚未明确莫达非尼的作用,但是研究认为莫达非尼可改变大脑中调节睡

近日,来自英国华威大学的商学院的一项新的研究发现表明,用于治疗发作性睡病等睡眠障碍处方药——莫达非尼,有助于治疗因食物上瘾而导致肥胖的人群,该研究结果已发表于Personality and Individual Differences。

莫达非尼是一种促醒剂用于治疗因发作性睡病、阻塞性睡眠呼吸暂停和轮班工作障碍所致的嗜睡。虽然目前尚未明确莫达非尼的作用,但是研究认为莫达非尼可改变大脑中调节睡眠和觉醒的神经介质,如5-羟色胺,从而促进觉醒。

此外,研究表明,莫达非尼能增加大脑中参与奖赏和成瘾的神经介质——多巴胺的水平。

研究还表明,食物成瘾的人往往缺乏某些特定的多巴胺,因为食物可以引发多巴胺的释放,故研究人员推测,食品成瘾者或通过不断进食而升高多巴胺的水平。

此外,研究人员注意到莫达非尼似乎减少在各种疾病下的冲动,包括精神分裂症、注意缺陷多动障碍(ADHD),与酒精依赖。

因为冲动行为是食物成瘾的关键因素,所以研究人员推测莫达非尼或有益于因食物上瘾而导致的肥胖人群。

该研究中,研究人员开始进一步研究莫达非尼和冲动之间的联系。

研究共招募了60名健康男性,年龄为19-32岁,随机分为3组。一组给予莫达非尼,另一组用atomoxetine(一种用于治疗ADHD的药物),最后一组接受安慰剂。

结果发现,服用莫达非尼的男性其冲动性显著降低,而atomoxetine组与安慰剂组的冲动性并无明显差异。

基于此研究结果,研究人员认为,莫达非尼或是治疗因食物上瘾所致肥胖的一个可行的治疗策略。

原始出处:

[1] Honor Whiteman. Could a narcolepsy drug help combat food addiction? MNT, 28 December 2016.

[2] Ivo Vlaev et al., Pharmacological manipulation of impulsivity: A randomized controlled trial, Personality and Individual Differences, 26 November 2016.


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    2017-01-01 李东泽

    很好,不错,以后会多学习

    0

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    2016-12-31 yhy100201
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    2016-12-29 李东泽

    很好,不错,以后会多学习

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1649660, encodeId=bed11649660b7, content=<a href='/topic/show?id=411d20003f3' target=_blank style='color:#2F92EE;'>#上瘾#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20003, encryptionId=411d20003f3, topicName=上瘾)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a6523894616, createdName=wangyang7966, createdTime=Mon Jul 24 01:35:00 CST 2017, time=2017-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1744993, encodeId=7d561e4499390, content=<a href='/topic/show?id=7c248e99138' target=_blank style='color:#2F92EE;'>#莫达非尼#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87991, encryptionId=7c248e99138, topicName=莫达非尼)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a78b35493023, createdName=tulenzi, createdTime=Sat May 20 15:35:00 CST 2017, time=2017-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=167242, encodeId=175816e24289, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Jan 01 13:18:37 CST 2017, time=2017-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416751, encodeId=98e41416e51f8, content=<a href='/topic/show?id=27c710101804' target=_blank style='color:#2F92EE;'>#食物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101018, encryptionId=27c710101804, topicName=食物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3a33221853, createdName=yhy100201, createdTime=Sat Dec 31 10:35:00 CST 2016, time=2016-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=166658, encodeId=51c516665800, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Thu Dec 29 21:56:33 CST 2016, time=2016-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=166641, encodeId=f04416664115, content=厉害了!!我的教授, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151110/IMG5641A6F12C0732294.jpg, createdBy=2f901662448, createdName=乐奕11, createdTime=Thu Dec 29 19:59:55 CST 2016, time=2016-12-29, status=1, ipAttribution=)]
    2016-12-29 乐奕11

    厉害了!!我的教授

    0

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