J Clin Endocrinol Meta: 睾酮疗法有效地改善老年男性的性活动

2016-06-30 Mechront 译 MedSci原创

近期有研究表明,对有症状的低睾酮水平的老年男性,使用持续睾酮治疗,能改善大多数类型的性活动。贝勒医学院和休斯敦贝勒圣路加医疗中心的Glenn R. Cunningham博士和他的同事评估了470名年龄在65岁或以上的性欲低下、平均睾酮275 ng/dL、有愿意一个月至少两次性交的伴侣的男性进行了此项睾酮试验。参与者被随机分配到的睾酮凝胶(AndroGel 1%, AbbVie; n = 234)

近期有研究表明,对有症状的低睾酮水平的老年男性,使用持续睾酮治疗,能改善大多数类型的性活动。

贝勒医学院和休斯敦贝勒圣路加医疗中心的Glenn R. Cunningham博士和他的同事评估了470名年龄在65岁或以上的性欲低下、平均睾酮275 ng/dL、有愿意一个月至少两次性交的伴侣的男性进行了此项睾酮试验。参与者被随机分配到的睾酮凝胶(AndroGel 1%, AbbVie; n = 234) 或安慰剂组(n = 236)。初始剂量为每天5 mg。在1、2、3、6和9个月分别测量血清睾酮浓度,评估从基线到3、6、9、和12个月的性功能的变化。

使用包含12个性兴趣和活动的特异性问题的性心理问卷调查评估在7天时间内性活动的改变,作为主要结果。次要结果包括性欲、勃起和性高潮功能的测量。使用DISF评估性欲、IIEF-EFD评估勃起功能、IIEF-OFD评估高潮功能。DISF-SDD小于20分定义为性欲降低;小于22分表明勃起功能障碍。

在12项措施的性活动,只有“被别人调情”和“每天自发勃起”是与治疗无显著相关的。

酒精摄入影响了睾丸激素对性的欲望和性活动的影响;每周摄入更多的酒精,与睾丸激素对性欲望和活动分数有更大的影响有关。卒中史、更高的国际前列腺症状评分会削弱睾酮对性欲的影响。更高的正面和负面影响尺度分数和冠状动脉疾病的历史会削弱睾酮对勃起功能障碍的影响。

研究人员写道:“对睾酮水平低的老年男性,使用睾酮治疗能改善其性行为、性欲望和勃起功能。其改善与睾酮、游离睾酮和雌二醇水平的改变有关。”

原始出处:

Cunningham GR, et al. Testosterone Treatment and Sexual Function in Older Men with Low Testosterone Levels
.J Clin Endocrinol Metab. 2016;doi:10.1210/jc.2016-1645.

Testosterone therapy effectively improves sexual activity in older men.Healio.June 29, 2016

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    2017-05-11 一闲
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    2016-09-04 fyxzlh
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    2017-01-13 guojianrong
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    2016-09-16 ylzr123

    赞!好文章拜读了,认真学习了。

    0

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    2016-09-12 1e10c84am36(暂无匿称)

    文章不错

    0

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    2016-09-09 1e10c84am36(暂无匿称)

    赞!好文章,拜读,深入学习。

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    2016-08-28 ylzr123

    深度好文,值得学习,赞!

    0

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