Lancet Diabetes Endo:BMI与疾病特异性死亡风险

2018-10-31 zhangfan MedSci原创

BMI

研究发现BMI与大多数疾病死亡风险呈J相关,而与精神、行为和神经疾病死亡风险呈负相关

近日研究人员就BMI 与特异性死亡风险之间的相关性进行了考察。

研究在英国开展,利用CPRD数据库资料,采用COX回归模型检验BMI与全因死亡率以及特定原因死亡率之间的关系。

总计3632674名16岁以上人群参与研究。在1969648名从不吸烟人群中,死亡188057人,BMI与全因死亡率呈J相关,与BMI=25 kg/m2人群相比,低于25 kg/m2人群的BMI每增加5 kg/m2,死亡风险增加0.81;高于25 kg/m2人群BMI每增加5 kg/m2,死亡风险增加1.21,除交通因素以外,包括肿瘤、血管疾病、呼吸系统疾病在内的大多数疾病符合该趋势,BMI保持在21-25范围内人群的死亡风险最低。对于精神、行为、神经系统和交通事故以外的意外,BMI在24-27范围内的人群其死亡风险最低,BMI与自残或人际暴力造成的死亡呈反向线性关联。相比于体重指数18.5-24.9人健康体重人群,对于40岁以上的肥胖人群(BMI≥30.0),男性平均寿命缩短4.2岁,女性缩短3.5岁;而对于40岁以上的低体重人群(BMI <8.5),男性平均寿命缩短4.3岁,女性缩短4.5岁。当考虑吸烟因素纳入考察范围后, BMI与死亡的相关性相近,但低体重者的相关性更为显著。

研究发现BMI与大多数疾病死亡风险呈J相关,而与精神、行为和神经疾病死亡风险呈负相关。

原始出处:


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    2019-08-25 howi
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