Cornea:深层前角膜层角膜移植术后大面积(9 mm)移植对各种基质疾病的免疫排斥

2018-03-16 cuiguizhong MedSci原创

意大利博洛尼亚大学眼科的Giannaccare G近日在Cornea杂志上发表了一篇文章,介绍了大深度前板层角膜移植术(DALK)后发生的免疫排斥反应的发生率和结果,并对潜在疾病在这个过程中的作用进行了分析。

意大利博洛尼亚大学眼科的Giannaccare G近日在Cornea杂志上发表了一篇文章,介绍了大深度前板层角膜移植术(DALK)后发生的免疫排斥反应的发生率和结果,并对潜在疾病在这个过程中的作用进行了分析。

他们回顾了Ospedali PrivatiForlì(意大利Forlì)进行的9毫米DALK所有眼睛的病例,并对相关图表进行分析。根据术前诊断,将眼睛分为,1-圆锥角膜,组2-排斥风险低的基质疾病,组3-排斥高风险的基质疾病。通过Kaplan-Meier分析,评估经历排斥反应的累积概率,并使用对数秩检验比较3组间的差异。比较排斥前和排斥后6个月时的校正距离视力、中央角膜厚度和内皮细胞密度。

分析发现,377只眼中有20只眼(5.3%)发生间质排斥反应。其中组1中265例中有17例,约占6.4%;组2中有2/71(2.8%),组3中有1/41(2.4%)。DALK和排斥发作之间的平均时间间隔为11.8个月,范围从1-24个月。排斥发作的累积概率在3组间没有显着差异。所有免疫排斥反应在发作后6个月内解决,同时矫正远视力、中央角膜厚度和内皮细胞密度的排斥前和排斥后6个月时没有显着差异。

因此,他们认为,大型9-mm DALK手术后的免疫排斥反应发生情况与文献报道的常规DALK手术之间没有显着差异,在其范围内。

原文出处:

Giannaccare, G., et al., Immunologic Stromal Rejection After Deep Anterior Lamellar Keratoplasty With Grafts of a Larger Size (9 mm) for Various Stromal Diseases. Cornea, 2018.

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  5. 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  6. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=297137, encodeId=818a29e1375d, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/01/15/8213228fe923915543544ad3da7e1c64.jpg, createdBy=6bd82014262, createdName=秀红, createdTime=Sat Mar 17 15:40:00 CST 2018, time=2018-03-17, status=1, ipAttribution=)]
    2018-03-18 snowpeakxu
  7. 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  8. 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  9. 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    2018-03-18 wzb521zf

    一起学习学习

    0

  10. 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    2018-03-17 秀红

    学习了

    0