新版中国糖尿病防治指南发布:降压目标130/80 mmHg,不推荐HbA1c诊断糖尿病,中医药写入指南

2018-02-07 xujing 中国循环杂志

近期,中华医学会糖尿病学分会正式发布了《中国2型糖尿病防治指南(2017年版)》。


近期,中华医学会糖尿病学分会正式发布了《中国2型糖尿病防治指南(2017年版)》。
 
新指南纳入了最新的中国人群的研究结果,更新了高血糖的诊断流程,并首次将中医药写入指南。
 
糖尿病综合控制标准与国内相关学术机构保持一致,并由心血管专科医师撰写相应章节。
 
糖尿病年轻化
 
新指南引用CDC等机构于2017年发表于JAMA上的流行病学数据:我国成人2型糖尿病患病率10.9%,且男性高于女性。
 
我国糖尿病患病在年轻化,40岁以下糖尿病患病率为5.9%。



国人特有基因增加糖尿病风险
 
此外,指南增加了中国人的遗传易感性的内容。目前全球已经定位超过100个2型糖尿病易感位点,其中仅30%在中国人群中得到验证,另外在中国人中发现PAX4、NOS1AP等多个2型糖尿病易感基因,这些基因可增加中国人2型糖尿病发生风险达5%~25%。
 
与中国人2型糖尿病显著相关的40个易感位点构建的遗传评分模型可应用于预测中国人2型糖尿病的发生,且主要与胰岛β细胞功能衰退有关。
 
不推荐HbA1c诊断糖尿病
 
鉴于HbA1c检测在我国尚不普遍,检测方法的标准化程度不够,测定HbA1c的仪器和质量控制尚不能符合目前糖尿病诊断标准的要求,新指南仍不推荐在我国采用HbA1c诊断糖尿病。
 
变更降糖治疗路径
 
新指南的重要变更之一是对临床降糖治疗具有指导原则的降糖治疗路径图进行了更新。
 
将以往的一线、二线、三线和四线药物治疗改为了单药、二联、三联和胰岛素多次注射。突出了二甲双胍的重要地位。
 
指南将起始胰岛素治疗的时机由HbA1c>7.0%改为≥7.0%。同时启用胰岛素强化治疗的时间也提前了,由HbA1c>9.0%调整为≥9.0%。
 
降压治疗目标值降至130/80 mmHg
 
新指南中,2型糖尿病的血压目标值由2013年指南中的140/90 mmHg降至130/80 mmHg。
 
指南建议,从>120/80 mmHg启动生活方式干预。≥140/90 mmHg者可考虑开始药物降压治疗
 
老年或伴严重冠心病的糖尿病患者,可采取相对宽松的降压目标值。
 
对于糖尿病患者的调脂治疗,新指南推荐降低LDL-C作为首要目标,非-HDL-C作为次要目标;起始宜应用低-中度强度他汀。
 
重视传统医学
 
指南还重视传统医学的价值,增加《糖尿病与中医药》一章。首次纳入了符合证据级别要求的糖尿病与中医药治疗的相关内容。
 
指南指出,中医药治疗糖尿病已经有两千年的历史,通过大量的循证证据证实,中医药在糖尿病的三级预防中发挥着重要的作用,为糖尿病防治提供了更多的选择。
 
本指南“建议” 所选择证据的原则是,SCI发表中国原创论文;随机、对照、双盲、多中心大样本临床研究;临床医生可合理合法使用(经典方剂或中成药)。
 


新指南还对2013版“妊娠糖尿病与糖尿病合并妊娠”部分进行了更加清晰的定义和阐述,统一为“妊娠合并高血糖状态”。
 

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channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Wed Feb 07 23:33:00 CST 2018, time=2018-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286051, encodeId=62a3286051b5, content=是很好的学习材料.不错.以后会多学习., beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Wed Feb 07 22:47:55 CST 2018, time=2018-02-07, status=1, ipAttribution=), 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    2018-04-17 Smile2680
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  5. 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    2018-02-09 hb2008ye
  6. 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    2018-02-08 Y—xianghai

    学习了新知识

    0

  7. 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channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Wed Feb 07 23:33:00 CST 2018, time=2018-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286051, encodeId=62a3286051b5, content=是很好的学习材料.不错.以后会多学习., beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Wed Feb 07 22:47:55 CST 2018, time=2018-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286040, encodeId=a25028604013, content=新指南.新指导., beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Wed Feb 07 22:16:32 CST 2018, time=2018-02-07, status=1, ipAttribution=)]
    2018-02-08 秀红

    学习了

    0

  8. 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    2018-02-07 有备才能无患

    近期.中华医学会糖尿病学分会正式发布了<中国2型糖尿病防治指南(2017年版)>.?新指南纳入了最新的中国人群的研究结果.更新了高血糖的诊断流程.并首次将中医药写入指南.

    0

  9. 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channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Wed Feb 07 23:33:00 CST 2018, time=2018-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286051, encodeId=62a3286051b5, content=是很好的学习材料.不错.以后会多学习., beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Wed Feb 07 22:47:55 CST 2018, time=2018-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286040, encodeId=a25028604013, content=新指南.新指导., beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Wed Feb 07 22:16:32 CST 2018, time=2018-02-07, status=1, ipAttribution=)]
    2018-02-07 李东泽

    是很好的学习材料.不错.以后会多学习.

    0

  10. 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attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Thu Feb 08 22:50:24 CST 2018, time=2018-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286128, encodeId=437e28612866, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/01/15/8213228fe923915543544ad3da7e1c64.jpg, createdBy=6bd82014262, createdName=秀红, createdTime=Thu Feb 08 05:53:29 CST 2018, time=2018-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286070, encodeId=adab2860e058, content=近期.中华医学会糖尿病学分会正式发布了<中国2型糖尿病防治指南(2017年版)>.?新指南纳入了最新的中国人群的研究结果.更新了高血糖的诊断流程.并首次将中医药写入指南., beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Wed Feb 07 23:33:00 CST 2018, time=2018-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286051, encodeId=62a3286051b5, content=是很好的学习材料.不错.以后会多学习., beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Wed Feb 07 22:47:55 CST 2018, time=2018-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286040, encodeId=a25028604013, content=新指南.新指导., beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Wed Feb 07 22:16:32 CST 2018, time=2018-02-07, status=1, ipAttribution=)]
    2018-02-07 1e0f8808m18(暂无匿称)

    新指南.新指导.

    0