JAMA Intern Med:老年人食盐过少或不降其死亡率和心血管疾病

2015-02-02 小田 译 医学论坛网

美国学者评估了老年人群盐摄入量和死亡、心血管疾病(CVD)和心力衰竭的相关性,结果该基于社区的前瞻性队列研究表明,老年人群摄入钠盐与10死亡、CVD或心衰不相关,摄入钠盐超过2.3 g/d与死亡率较高的相关性不显著。相关论文1月19日在线发表于《美国医学会杂志·内科学》(JAMA Intern Med)。 研究者们对2642例老年人(年龄范围71-80岁,平均年龄为73.6岁,女性51.2%,白

美国学者评估了老年人群盐摄入量和死亡、心血管疾病(CVD)和心力衰竭的相关性,结果该基于社区的前瞻性队列研究表明,老年人群摄入钠盐与10死亡、CVD或心衰不相关,摄入钠盐超过2.3 g/d与死亡率较高的相关性不显著。相关论文1月19日在线发表于《美国医学会杂志·内科学》(JAMA Intern Med)。

研究者们对2642例老年人(年龄范围71-80岁,平均年龄为73.6岁,女性51.2%,白种人61.7%,黑种人38.3%)的10年随访数据进行了分析。通过食物频次调查问卷形式评估其基线饮食钠盐摄入。将钠盐摄入量作为连续变量并进行以下分类:<1.5 g/d(291 例,11.0%),1.5—2.3 g/d(779 例,29.5%),>2.3 g/d(1572例,59.5%)。在10年随访期间评估受试者的死亡、CVD和心衰的发生率。CVD发生率的分析数据限定在基线无CVD的1981例受试者。

结果显示,10年随访结束后,死亡、发生CVD和心衰的患者例数分别为881例、572例和398例。在校正Cox比例风险回归模型中,钠盐摄入与死亡率不相关[每1 g的危险比(HR)为1.03 ;P= .27]。与摄入钠盐<1.5 g/d (33.8%)和>2.3 g/d(35.2%)的受试者相比,摄入钠盐1.5—2.3 g/d(30.7%)的受试者10年死亡率不显著降低(P=0.07)。摄入钠盐>2.3 g/d的受试者的死亡率升高不显著(HR vs 1.5-2.3g/d 1.15;P= 0.07)。

热量摄入和体质指数(BMI)加入到钠盐摄入索引中实质上并不影响结果。每1mg·千卡钠和每100 mg/kg/m2盐摄入的死亡率校正HR分别为1.20和 1.11。在校正死亡的竞争风险分析中,钠盐摄入与CVD或心衰风险不相关。

根据世界卫生组织发布的相关指南,成年人每天应摄入钠不超过2000mg,即每天不超过5克盐,钾每日至少3510mg。这项研究可谓是再掀起了限盐与否的波澜,到底限不限盐,且看·AHA主席回应到底该不该限盐

原始出处:

Kalogeropoulos AP1, Georgiopoulou VV1, Murphy RA2, Newman AB3, Bauer DC4, Harris TB2, Yang Z5, Applegate WB6, Kritchevsky SB6.Dietary Sodium Content, Mortality, and Risk for Cardiovascular Events in Older Adults: The Health, Aging, and Body Composition (Health ABC) Study.JAMA Intern Med. 2015 Jan 19. doi: 10.1001/jamainternmed.2014.6278. [Epub ahead of print]

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    2015-02-17 chinayinhan

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    2015-02-04 lingqf
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  5. [GetPortalCommentsPageByObjectIdResponse(id=16204, encodeId=12291620472, content=已阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=da6b7222, createdName=chinayinhan, createdTime=Tue Feb 17 00:55:00 CST 2015, time=2015-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1423673, encodeId=60c014236e3d0, content=<a href='/topic/show?id=cfd51010566b' target=_blank style='color:#2F92EE;'>#食盐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101056, encryptionId=cfd51010566b, topicName=食盐)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c1c53824481, createdName=lingqf, createdTime=Wed Feb 04 06:20:00 CST 2015, time=2015-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1497867, encodeId=1283149e86738, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Wed Feb 04 06:20:00 CST 2015, time=2015-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606390, encodeId=475216063908d, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Wed Feb 04 06:20:00 CST 2015, time=2015-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14985, encodeId=a22d14985a7, content=喜欢吃腌制食物的我放心了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=pangshiwei, createdTime=Mon Feb 02 19:40:00 CST 2015, time=2015-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14963, encodeId=8c41149639d, content=确实, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=116.231.231.**, createdTime=Mon Feb 02 17:13:00 CST 2015, time=2015-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14961, encodeId=9e6414961d3, content=我们自己都要坚强!, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=116.231.231.**, createdTime=Mon Feb 02 17:10:00 CST 2015, time=2015-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14960, encodeId=c5bb149605e, content=Jama !, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150824/IMG55DADEB16559C6117.jpg, createdBy=1aa21613630, createdName=ioslove, createdTime=Mon Feb 02 16:37:00 CST 2015, time=2015-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14955, encodeId=5a461495569, content=JAMA Intern Med !, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=116.231.231.**, createdTime=Mon Feb 02 16:10:00 CST 2015, time=2015-02-02, status=1, ipAttribution=)]
    2015-02-02 pangshiwei

    喜欢吃腌制食物的我放心了!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=16204, encodeId=12291620472, content=已阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=da6b7222, createdName=chinayinhan, createdTime=Tue Feb 17 00:55:00 CST 2015, time=2015-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1423673, encodeId=60c014236e3d0, content=<a href='/topic/show?id=cfd51010566b' target=_blank style='color:#2F92EE;'>#食盐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101056, encryptionId=cfd51010566b, topicName=食盐)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c1c53824481, createdName=lingqf, createdTime=Wed Feb 04 06:20:00 CST 2015, time=2015-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1497867, encodeId=1283149e86738, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Wed Feb 04 06:20:00 CST 2015, time=2015-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606390, encodeId=475216063908d, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Wed Feb 04 06:20:00 CST 2015, time=2015-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14985, encodeId=a22d14985a7, content=喜欢吃腌制食物的我放心了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=pangshiwei, createdTime=Mon Feb 02 19:40:00 CST 2015, time=2015-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14963, encodeId=8c41149639d, content=确实, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=116.231.231.**, createdTime=Mon Feb 02 17:13:00 CST 2015, time=2015-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14961, encodeId=9e6414961d3, content=我们自己都要坚强!, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=116.231.231.**, createdTime=Mon Feb 02 17:10:00 CST 2015, time=2015-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14960, encodeId=c5bb149605e, content=Jama !, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150824/IMG55DADEB16559C6117.jpg, createdBy=1aa21613630, createdName=ioslove, createdTime=Mon Feb 02 16:37:00 CST 2015, time=2015-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14955, encodeId=5a461495569, content=JAMA Intern Med !, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=116.231.231.**, createdTime=Mon Feb 02 16:10:00 CST 2015, time=2015-02-02, status=1, ipAttribution=)]
    2015-02-02 116.231.231.**

    确实

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=16204, encodeId=12291620472, content=已阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=da6b7222, createdName=chinayinhan, createdTime=Tue Feb 17 00:55:00 CST 2015, time=2015-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1423673, encodeId=60c014236e3d0, content=<a href='/topic/show?id=cfd51010566b' target=_blank style='color:#2F92EE;'>#食盐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101056, encryptionId=cfd51010566b, topicName=食盐)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c1c53824481, createdName=lingqf, createdTime=Wed Feb 04 06:20:00 CST 2015, time=2015-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1497867, encodeId=1283149e86738, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Wed Feb 04 06:20:00 CST 2015, time=2015-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606390, encodeId=475216063908d, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Wed Feb 04 06:20:00 CST 2015, time=2015-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14985, encodeId=a22d14985a7, content=喜欢吃腌制食物的我放心了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=pangshiwei, createdTime=Mon Feb 02 19:40:00 CST 2015, time=2015-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14963, encodeId=8c41149639d, content=确实, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=116.231.231.**, createdTime=Mon Feb 02 17:13:00 CST 2015, time=2015-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14961, encodeId=9e6414961d3, content=我们自己都要坚强!, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=116.231.231.**, createdTime=Mon Feb 02 17:10:00 CST 2015, time=2015-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14960, encodeId=c5bb149605e, content=Jama !, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150824/IMG55DADEB16559C6117.jpg, createdBy=1aa21613630, createdName=ioslove, createdTime=Mon Feb 02 16:37:00 CST 2015, time=2015-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14955, encodeId=5a461495569, content=JAMA Intern Med !, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=116.231.231.**, createdTime=Mon Feb 02 16:10:00 CST 2015, time=2015-02-02, status=1, ipAttribution=)]
    2015-02-02 116.231.231.**

    我们自己都要坚强!

    0

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    2015-02-02 ioslove

    Jama !

    0

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    2015-02-02 116.231.231.**

    JAMA Intern Med !

    0

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