Med Sci Monit:常规血液相关炎症指标或可作为乳腺癌诊断的辅助指标

2017-11-09 MedSci MedSci原创

目前已知,慢性炎症与癌症的发展密切相关。作为一项简单的无创血液检测,常规血液检查中的血液学参数可看做是炎症标志物。本研究旨在评估血小板计数(PC),红细胞分布宽度(RDW),白细胞计数(WBC),平均血小板体积(MPV),中性粒细胞/淋巴细胞比例(NLR)和血小板计数/淋巴细胞比率(PLR)作为乳腺癌(BC)患者的替代炎性标志物,然后将其与健康个体进行比较。2014年7月至2015年4月在武汉大学

目前已知,慢性炎症与癌症的发展密切相关。作为一项简单的无创血液检测,常规血液检查中的血液学参数可看做是炎症标志物。本研究旨在评估血小板计数(PC),红细胞分布宽度(RDW),白细胞计数(WBC),平均血小板体积(MPV),中性粒细胞/淋巴细胞比例(NLR)和血小板计数/淋巴细胞比率(PLR)作为乳腺癌(BC)患者的替代炎性标志物,然后将其与健康个体进行比较。

2014年7月至2015年4月在武汉大学中南医院进行此项回顾性研究分析,纳入了110例病理确诊的BC患者和78名健康女性。对两组参与者的血液学参数进行回顾性分析,以评估这些指标与110例乳腺癌患者临床病理特征的相关性。

结果显示,BC患者的RDW、MPv、NLR和PLR的平均值明显高于对照组。术前BCV患者的MPV水平与淋巴结转移及Ki67增殖指数呈正相关(P <0.05)。 Logistic回归分析进一步显示,MPV与BC淋巴结转移风险独立相关(P <0.05)。

结果表明,RDW、MPV、NLR和PLR的血液学参数可以作为BC诊断的辅助工具。更重要的是,MPV可以反映术前的Ki67增殖指数,并可鉴别淋巴结转移阳性的患者。

原始出处:

Hong Sun, Chang-qing Yin, et al., Clinical Significance of Routine Blood Test-Associated Inflammatory Index in Breast Cancer Patients. Med Sci Monit. 2017; 23: 5090–5095. Published online 2017 Oct 25. doi: 10.12659/MSM.906709

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    2018-05-28 2824896105_45376428

    学习了长知识了

    0

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    2017-11-12 jennyli5986

    学习了

    0

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