Eur Arch Otorhinolaryngol:耳硬化不同阶段的3D液体衰减反转恢复磁共振成像研究

2018-09-20 AlexYang MedSci原创

最近,有研究人员通过3D-FLAIR序列核磁共振成像(MRI)和钆给药或者不给药(-/+Gd)对耳硬化患者进行了研究,从而理解是否3D FLAIR MRI序列的放射学发现与耳硬化患者一些临床特性相关,比如感官神经参与、疾病持续时间、患者性别和其他因素。研究包括了38名受不同阶段单边或者双边耳硬化的患者,并且他们均经历了3D FLAIR MRI+/- Gd。11名听力正常,但因为其他小的疾病而参与了

最近,有研究人员通过3D-FLAIR序列核磁共振成像(MRI)和钆给药或者不给药(-/+Gd)对耳硬化患者进行了研究,从而理解是否3D FLAIR MRI序列的放射学发现与耳硬化患者一些临床特性相关,比如感官神经参与、疾病持续时间、患者性别和其他因素。

研究包括了38名受不同阶段单边或者双边耳硬化的患者,并且他们均经历了3D FLAIR MRI+/- Gd。11名听力正常,但因为其他小的疾病而参与了3T MRI,且与耳硬化无关。这些参与者作为研究的对照。研究发现,3D FLAIR MRI与耳硬化的一些临床特性显著相关,比如耳蜗损伤的严重度和疾病持续的时间。他们的发现表明了3D FLAIR MRI的不同模式可能依赖耳蜗中血迷路屏障的损伤情况,并且与耳硬化患者中不同阶段的耳蜗参与相关。

最后,研究人员指出,他们的发现能够为耳硬化患者中耳蜗损伤的致病机制提供理解,并且也许具有更深的预后价值。他们的结果使得使用 3D-FLAIR序列在任何耳硬化药物治疗中效果的评估中成为可能,并且还可以选择那些患者适合治疗。

原始出处:

Berrettini S, Lombardo F, Bruschini L et al. 3D fluid attenuated inversion recovery (FLAIR) magnetic resonance imaging at different stages of otosclerosis. Eur Arch Otorhinolaryngol. 06 Sep 2018.

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    2018-10-09 jambiya
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    2018-09-20 天地飞扬

    了解一下,谢谢分享!

    0

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