Oral Oncol:不刷牙,小心头颈癌找上你

2015-05-03 sunshine 译 MedSci原创

头颈癌(HNC)是指发生在口腔、咽喉、鼻窦、喉部、头骨基部以及头部的恶性肿瘤,是世界上第六好发癌症,其治疗难度较大。因此,了解HNC发生的任何有关因素都很重要,吸烟和喝酒是已确定的危险因素,而且是HNC发生的主要病因。其他的危险因素包括遗传因素、人类乳头瘤病毒(HPV)感染、牙周病、牙齿丧失、口腔卫生较差、较差的牙齿状态等在HNC的发生中也有作用。牙菌


头颈癌(HNC)是指发生在口腔、咽喉、鼻窦、喉部、头骨基部以及头部的恶性肿瘤,是世界上第六好发癌症,其治疗难度较大。因此,了解HNC发生的任何有关因素都很重要,吸烟和喝酒是已确定的危险因素,而且是HNC发生的主要病因。其他的危险因素包括遗传因素、人类乳头瘤病毒(HPV)感染、牙周病、牙齿丧失、口腔卫生较差、较差的牙齿状态等在HNC的发生中也有作用。

牙菌斑是龋病、牙龈炎、牙周病、牙齿丧失、口腔卫生差的原因。因此,去除牙菌斑在预防这些疾病的发生上具有重要的作用。现有的证据表明,刷牙是清除牙菌斑的有效方法,预防口腔疾病或可减少HNC的发生。

已有流行病学研究聚焦在刷牙与HNC之间的关系,然而,刷牙是否会降低头颈癌发生的风险尚未清楚。有由于目前还未有综述或meta分析来为此重要的临床问题提供定量的证据,因此我们做了此meta分析以调查刷牙与HNC发生风险之间的关系。

我们在PubMed 与 Embase上检索了截至2014年1月13日相关的文献,以明确观察刷牙与HNC之间的关系。经过研究筛选和数据提取,使用 RevMan 5.2进行此meta分析。

研究共纳入了18例病例对照研究,包含了7068个病例和9990个对照组。meta分析显示,与刷牙频率最高相比,刷牙频率最低的患HNC的风险显著提高了2.08倍(比值比 = 2.08, 95% 的可信区间 = 1.65–2.62)。校正了吸烟和喝酒因素后,其结果仍保持一致。

该meta分析表明,刷牙的频率与头HNC发生的风险显著相关。有效的刷牙可能是预防HNC的潜在措施,因此,我们建议刷牙的频率为每天两次(早上和晚上)。

原始出处:

Zeng XT, Leng WD, Zhang C, Liu J, Cao SY, Huang W.Meta-analysis on the association between toothbrushing and head and neck cancer.Oral Oncol. 2015 May;51(5):446-51. doi: 10.1016/j.oraloncology.2015.02.095. Epub 2015 Mar 6.

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    2016-09-13 1e10c84am36(暂无匿称)

    好文章,还会关注

    0

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    2015-05-28 minlingfeng
  3. [GetPortalCommentsPageByObjectIdResponse(id=125344, encodeId=594e125344be, content=好文章,还会关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Sep 13 14:27:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1864649, encodeId=9f14186464947, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Thu May 28 14:40:00 CST 2015, time=2015-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2020163, encodeId=7fb12020163c8, content=<a href='/topic/show?id=1584134451c' target=_blank style='color:#2F92EE;'>#Oral#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13445, encryptionId=1584134451c, topicName=Oral)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Mon Feb 22 21:40:00 CST 2016, time=2016-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1295867, encodeId=4a44129586ee2, content=<a href='/topic/show?id=f30a4441598' target=_blank style='color:#2F92EE;'>#头颈癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44415, encryptionId=f30a4441598, topicName=头颈癌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6c32257, createdName=DEXTER3139, createdTime=Tue May 05 07:40:00 CST 2015, time=2015-05-05, status=1, ipAttribution=)]
    2016-02-22 小几洁
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