Prostate Cancer P D:总量和酒精饮料摄入与侵入性前列腺癌风险

2017-04-30 AlexYang MedSci原创

酒精饮料中的乙醇是知名的致癌物质,但是它与侵入性前列腺癌(APC)的关系却并不知晓。近期的一些研究指出,APC患病率的一定程度增加与大量酒精摄入有关系,但是对酒精饮料的类型仍旧不清楚。最近,研究人员利用案例-对照设计和自我陈述调查就APC与酒精摄入频率和量的关系进行了研究,酒精摄入超过两年的优先考虑,并且APC包括高级和晚期两种阶段。更多的是,研究人员描述了酒精饮料啤酒、红酒、白酒和烈酒与APC的

酒精饮料中的乙醇是知名的致癌物质,但是它与侵入性前列腺癌(APC)的关系却并不知晓。近期的一些研究指出,APC患病率的一定程度增加与大量酒精摄入有关系,但是对酒精饮料的类型仍旧不清楚。最近,研究人员利用案例-对照设计和自我陈述调查就APC与酒精摄入频率和量的关系进行了研究,酒精摄入超过两年的优先考虑,并且APC包括高级和晚期两种阶段。更多的是,研究人员描述了酒精饮料啤酒、红酒、白酒和烈酒与APC的关系。

该研究包括1282个APC病例和951名对照。研究发现,和没有啤酒摄入的对比,每周啤酒摄入频率不小于5天的APC风险增加(odds ratio=1.66, 95% confidence interval: 1.12-2.48),然而,和没有白酒摄入的对比,所有白酒消费频率都表现出保护性作用。对于每周从啤酒中摄入10g酒精的案例,晚期PC的患病率增加了3%(OR=1.03, 95% CI: 1.02-1.05)。而在红酒和白酒摄入中没有发现该情况,但是烈酒的摄入与APC患病率的增加有着边际剂量响应关系(OR=1.03, 95% CI: 0.99-1.07)。最后,研究人员指出,大量啤酒和烈酒的消费和APC患病率的赠酒有关系,但是在红酒和白酒中并未发现有类似关系。相反,和那些不饮用白酒的对比,白酒的饮用能够降低APC患病率。

原始出处:

N P Papa, R J MacInnis, H Jayasekara et al. Total and beverage-specific alcohol intake and the risk of aggressive prostate cancer: a case-control study. Prostate Cancer P D. 18 April 2017. doi:10.1038/pcan.2017.12.

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    2018-03-25 sjq027
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    2017-05-02 lsndxfj
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    2017-05-02 sunylz

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