J Periodontal Implant Sci:牙周和牙髓病变可影响拔牙窝的愈合

2017-07-10 MedSci MedSci原创

本研究目的是评估牙周病和牙髓病病史的患牙拔除后拔牙窝的愈合情况。选取5只成年比格犬,以其下颌第四前磨牙为实验部位。在第一磨牙部位使用钢丝结扎和牙髓暴露3个月诱导牙周牙髓病变(实验组)。健侧前磨牙部位为健康对照组。然后微创拔除下颌第四颗前磨牙,仔细清创。分别于术后1, 7, 30、60、90天处死动物,观察动物拔牙窝的愈合情况。使用 X光线照相术、扫描电子显微镜、组织学和histometry来对比健

本研究目的是评估牙周病和牙髓病病史的患牙拔除后拔牙窝的愈合情况。

选取5只成年比格犬,以其下颌第四前磨牙为实验部位。在第一磨牙部位使用钢丝结扎和牙髓暴露3个月诱导牙周牙髓病变(实验组)。健侧前磨牙部位为健康对照组。然后微创拔除下颌第四颗前磨牙,仔细清创。分别于术后1, 7, 30、60、90天处死动物,观察动物拔牙窝的愈合情况。使用 X光线照相术、扫描电子显微镜、组织学和histometry来对比健患侧。

结果,在愈合的前7天,实验组拔牙创部位存在明显的炎症。第1天可见拔牙窝内存在肉芽组织,第7天纤维蛋白凝块的分解速度略有加快。第30天,拔牙窝内骨纤维结缔组织增多,无骨髓形成。

相比之下,健康组拔牙窝在第30天显示骨髓形成的初步迹象,并在随后的60天和90天显着更大比例的成熟骨髓。X线片表现临近根尖牙髓病变部位出现硬化高密度影,扫描电镜显示拔牙窝区域突出倒塌的Volkmann管。此外,牙周韧带纤维与病变部位的牙槽窝壁平行排列,与健康部位的垂直排列相反。

总而言之,该研究发现,牙周和牙髓病病史可能严重影响骨的形成和成熟,导致拔牙窝延迟愈合。

原始出处:

Jung-Hoon Kim, Ki-Tae Koo, et al,. Wikesjö. Periodontal and endodontic pathology delays extraction socket healing in a canine model. J Periodontal Implant Sci. 2017 Jun; 47(3): 143–153. Published online 2017 Jun 28. doi: 10.5051/jpis.2017.47.3.143.

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    2018-04-29 xuyu
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    2018-03-01 xuyong536
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    2018-03-11 luwei00
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1789150, encodeId=831f1e891503f, content=<a href='/topic/show?id=0c8814344f5' target=_blank style='color:#2F92EE;'>#plant#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14344, encryptionId=0c8814344f5, topicName=plant)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f5b299, createdName=xuyu, createdTime=Sun Apr 29 21:32:00 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1773180, encodeId=55781e7318033, content=<a href='/topic/show?id=5298121e46e' target=_blank style='color:#2F92EE;'>#MPL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12174, encryptionId=5298121e46e, topicName=MPL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=10e638510530, createdName=xuyong536, createdTime=Thu Mar 01 22:32:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1953610, encodeId=ddd2195361015, content=<a href='/topic/show?id=86156e68526' target=_blank style='color:#2F92EE;'>#牙髓病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67685, encryptionId=86156e68526, topicName=牙髓病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e093393, createdName=luwei00, createdTime=Sun Mar 11 05:32:00 CST 2018, time=2018-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1994437, encodeId=1ff9199443e7c, content=<a href='/topic/show?id=a82156216d3' target=_blank style='color:#2F92EE;'>#拔牙窝#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56216, encryptionId=a82156216d3, topicName=拔牙窝)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=baf586, createdName=wangbingxhy, createdTime=Thu Mar 22 08:32:00 CST 2018, time=2018-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1669588, encodeId=3f3e166958870, content=<a href='/topic/show?id=c7ca6e660ab' target=_blank style='color:#2F92EE;'>#牙髓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67660, encryptionId=c7ca6e660ab, topicName=牙髓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5eeb26562774, createdName=jxrzshh, createdTime=Thu Nov 09 19:32:00 CST 2017, time=2017-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726567, encodeId=79a31e265670d, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Aug 06 09:32:00 CST 2017, time=2017-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450553, encodeId=76ab145055336, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Wed Jul 12 07:32:00 CST 2017, time=2017-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1574215, encodeId=e70815e4215be, content=<a href='/topic/show?id=36fc56212c6' target=_blank style='color:#2F92EE;'>#拔牙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56212, encryptionId=36fc56212c6, topicName=拔牙)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9c5216012416, createdName=xre2013, createdTime=Wed Jul 12 07:32:00 CST 2017, time=2017-07-12, status=1, ipAttribution=)]
    2017-11-09 jxrzshh
  6. [GetPortalCommentsPageByObjectIdResponse(id=1789150, encodeId=831f1e891503f, content=<a href='/topic/show?id=0c8814344f5' target=_blank style='color:#2F92EE;'>#plant#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14344, encryptionId=0c8814344f5, topicName=plant)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f5b299, createdName=xuyu, createdTime=Sun Apr 29 21:32:00 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1773180, encodeId=55781e7318033, content=<a href='/topic/show?id=5298121e46e' target=_blank style='color:#2F92EE;'>#MPL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12174, encryptionId=5298121e46e, topicName=MPL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=10e638510530, createdName=xuyong536, createdTime=Thu Mar 01 22:32:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1953610, encodeId=ddd2195361015, content=<a href='/topic/show?id=86156e68526' target=_blank style='color:#2F92EE;'>#牙髓病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67685, encryptionId=86156e68526, topicName=牙髓病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e093393, createdName=luwei00, createdTime=Sun Mar 11 05:32:00 CST 2018, time=2018-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1994437, encodeId=1ff9199443e7c, content=<a href='/topic/show?id=a82156216d3' target=_blank style='color:#2F92EE;'>#拔牙窝#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56216, encryptionId=a82156216d3, topicName=拔牙窝)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=baf586, createdName=wangbingxhy, createdTime=Thu Mar 22 08:32:00 CST 2018, time=2018-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1669588, encodeId=3f3e166958870, content=<a href='/topic/show?id=c7ca6e660ab' target=_blank style='color:#2F92EE;'>#牙髓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67660, encryptionId=c7ca6e660ab, topicName=牙髓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5eeb26562774, createdName=jxrzshh, createdTime=Thu Nov 09 19:32:00 CST 2017, time=2017-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726567, encodeId=79a31e265670d, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Aug 06 09:32:00 CST 2017, time=2017-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450553, encodeId=76ab145055336, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Wed Jul 12 07:32:00 CST 2017, time=2017-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1574215, encodeId=e70815e4215be, content=<a href='/topic/show?id=36fc56212c6' target=_blank style='color:#2F92EE;'>#拔牙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56212, encryptionId=36fc56212c6, topicName=拔牙)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9c5216012416, createdName=xre2013, createdTime=Wed Jul 12 07:32:00 CST 2017, time=2017-07-12, status=1, ipAttribution=)]
    2017-08-06 feather89
  7. [GetPortalCommentsPageByObjectIdResponse(id=1789150, encodeId=831f1e891503f, content=<a href='/topic/show?id=0c8814344f5' target=_blank style='color:#2F92EE;'>#plant#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14344, encryptionId=0c8814344f5, topicName=plant)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f5b299, createdName=xuyu, createdTime=Sun Apr 29 21:32:00 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1773180, encodeId=55781e7318033, content=<a href='/topic/show?id=5298121e46e' target=_blank style='color:#2F92EE;'>#MPL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12174, encryptionId=5298121e46e, topicName=MPL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=10e638510530, createdName=xuyong536, createdTime=Thu Mar 01 22:32:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1953610, encodeId=ddd2195361015, content=<a href='/topic/show?id=86156e68526' target=_blank style='color:#2F92EE;'>#牙髓病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67685, encryptionId=86156e68526, topicName=牙髓病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e093393, createdName=luwei00, createdTime=Sun Mar 11 05:32:00 CST 2018, time=2018-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1994437, encodeId=1ff9199443e7c, content=<a href='/topic/show?id=a82156216d3' target=_blank style='color:#2F92EE;'>#拔牙窝#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56216, encryptionId=a82156216d3, topicName=拔牙窝)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=baf586, createdName=wangbingxhy, createdTime=Thu Mar 22 08:32:00 CST 2018, time=2018-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1669588, encodeId=3f3e166958870, content=<a href='/topic/show?id=c7ca6e660ab' target=_blank style='color:#2F92EE;'>#牙髓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67660, encryptionId=c7ca6e660ab, topicName=牙髓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5eeb26562774, createdName=jxrzshh, createdTime=Thu Nov 09 19:32:00 CST 2017, time=2017-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726567, encodeId=79a31e265670d, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Aug 06 09:32:00 CST 2017, time=2017-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450553, encodeId=76ab145055336, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Wed Jul 12 07:32:00 CST 2017, time=2017-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1574215, encodeId=e70815e4215be, content=<a href='/topic/show?id=36fc56212c6' target=_blank style='color:#2F92EE;'>#拔牙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56212, encryptionId=36fc56212c6, topicName=拔牙)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9c5216012416, createdName=xre2013, createdTime=Wed Jul 12 07:32:00 CST 2017, time=2017-07-12, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1789150, encodeId=831f1e891503f, content=<a href='/topic/show?id=0c8814344f5' target=_blank style='color:#2F92EE;'>#plant#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14344, encryptionId=0c8814344f5, topicName=plant)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f5b299, createdName=xuyu, createdTime=Sun Apr 29 21:32:00 CST 2018, time=2018-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1773180, encodeId=55781e7318033, content=<a href='/topic/show?id=5298121e46e' target=_blank style='color:#2F92EE;'>#MPL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12174, encryptionId=5298121e46e, topicName=MPL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=10e638510530, createdName=xuyong536, createdTime=Thu Mar 01 22:32:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1953610, encodeId=ddd2195361015, content=<a href='/topic/show?id=86156e68526' target=_blank style='color:#2F92EE;'>#牙髓病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67685, encryptionId=86156e68526, topicName=牙髓病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e093393, createdName=luwei00, createdTime=Sun Mar 11 05:32:00 CST 2018, time=2018-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1994437, encodeId=1ff9199443e7c, content=<a href='/topic/show?id=a82156216d3' target=_blank style='color:#2F92EE;'>#拔牙窝#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56216, encryptionId=a82156216d3, topicName=拔牙窝)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=baf586, createdName=wangbingxhy, createdTime=Thu Mar 22 08:32:00 CST 2018, time=2018-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1669588, encodeId=3f3e166958870, content=<a href='/topic/show?id=c7ca6e660ab' target=_blank style='color:#2F92EE;'>#牙髓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67660, encryptionId=c7ca6e660ab, topicName=牙髓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5eeb26562774, createdName=jxrzshh, createdTime=Thu Nov 09 19:32:00 CST 2017, time=2017-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726567, encodeId=79a31e265670d, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Aug 06 09:32:00 CST 2017, time=2017-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450553, encodeId=76ab145055336, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Wed Jul 12 07:32:00 CST 2017, time=2017-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1574215, encodeId=e70815e4215be, content=<a href='/topic/show?id=36fc56212c6' target=_blank style='color:#2F92EE;'>#拔牙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56212, encryptionId=36fc56212c6, topicName=拔牙)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9c5216012416, createdName=xre2013, createdTime=Wed Jul 12 07:32:00 CST 2017, time=2017-07-12, status=1, ipAttribution=)]
    2017-07-12 xre2013

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