J Periodontal Res:氧化锆和钛种植体的骨整合哪个好?

2019-08-12 不详 网络

本研究旨在对比含有氧化钇(M-Y-TZP)的机加工氧化锆植入物与机械加工(M-Ti)和可再吸收喷砂介质(RBM-Ti)钛植入物的骨整合。将M-Y-TZP,M-Ti和RBM-Ti植入物随机置于兔胫骨中。在不同时间段施用荧光染料骨标记物(四环素,茜素和钙黄绿素)。8周后,使用显微CT和组织形态学分析,评估骨与植入物接触(BIC),新骨面积(nBA),剩余皮质骨区域(rBA)和荧光染料的时间定量方面的骨

本研究旨在对比含有氧化钇(M-Y-TZP)的机加工氧化锆植入物与机械加工(M-Ti)和可再吸收喷砂介质(RBM-Ti)钛植入物的骨整合。

将M-Y-TZP,M-Ti和RBM-Ti植入物随机置于兔胫骨中。在不同时间段施用荧光染料骨标记物(四环素,茜素和钙黄绿素)。8周后,使用显微CT和组织形态学分析,评估骨与植入物接触(BIC),新骨面积(nBA),剩余皮质骨区域(rBA)和荧光染料的时间定量方面的骨整合。

结果,RBM-Ti植入物(rBA = 36.9%和nBA = 38.8%)显示出比M-Y-TZP植入物(rBA = 48%和nBA = 26.5%)更高的剩余皮质骨的再吸收和骨形成。BIC值显示皮质区域组之间无差异(平均值= 52.2%),但在髓质区域,RBM-Ti组(51.2%)比MY-TZP组高0.45倍(35.2%)。在所有组中,观察到四环素的高掺入(第2至第4周),然后是茜素红(第4至第6周)和钙黄绿素(第6至第8周)。在皮层区域,四环素的掺入在RBM-Ti(49.8%)和M-Y-TZP(35.9%)植入物之间相似,但高于M-Ti(28.2%)植入物。随后,RBM-Ti植入物中的茜素和钙黄绿素比其他植入物高1.1倍。在髓质区域,未观察到所有荧光染料的明显差异。

总之,所有植入物都有利于骨形成,因此促进了初期稳定性。在RBM-Ti和MY-TZP种植体中,线性骨形成比在M-Ti种植体中更快,但MY-TZP种植体随着时间的推移有限的骨重建会对二次稳定性产生显著影响,这表明其作为钛植入物替代方案使用时要谨慎。

原始出处:

Martins R, Cestari TM, et al., Osseointegration of zirconia and titanium implants in a rabbit tibiae model evaluated by microtomography, histomorphometry and fluorochrome labeling analyses. J Periodontal Res. 2018 Apr;53(2):210-221. doi: 10.1111/jre.12508. Epub 2017 Oct 17.

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    2019-11-18 30397613
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    2019-12-03 huangdf
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