Endocrine:活跃的Graves眼病患者的泪液中细胞因子图谱!

2017-12-27 cuiguizhong MedSci原创

新加坡国家眼科中心的Yang M近日在Endocrine发表了一项新的工作,他们从患格雷夫斯眼眶病(GO)患者的泪液中分离特异活性的细胞因子,并对其他感兴趣的细胞因子进行观察。

新加坡国家眼科中心的Yang M近日在Endocrine发表了一项新的工作,他们从患格雷夫斯眼眶病(GO)患者的泪液中分离特异活性的细胞因子,并对其他感兴趣的细胞因子进行观察。

他们的这项研究是在新加坡国家眼科中心进行的,是一项前瞻性的试验性研究。总共有10名格雷夫斯眼眶病(GO)患者和来自3个对照组的10名患者被招募。3个对照组设置如下:年龄相当的正常女性患者,临床诊断为潜在的GO患者和双侧病毒性结膜炎患者。来自对照组患者的眼泪是在一次访问中收集的。对于活跃的GO患者,分别在6个月、12个月和18个月的时候收集眼泪。

他们分析发现,在所有检查的细胞因子中,比较活跃GO患者组与所有对照组发现,只有IL-7具有显着的差异。这一差异在随访的18个月时最为显着。

因此,他们认为,泪液中低浓度的IL-7可以作为格雷夫斯眼眶病(GO)发病的特异性诊断指标,它可以比临床提早2年发现。使用泪液中的IL-7作为疾病活性的生物标志物可能因其晚期特征而受到限制,但使用IL-7靶向免疫治疗可能改善疾病。

原文出处:

Yang, M., et al. The tear cytokine profile in patients with active Graves' orbitopathy. Endocrine, 2017

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    2018-04-08 xinmeili
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    2017-12-30 李香香

    0

  4. 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topicName=Graves)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f49517, createdName=xinmeili, createdTime=Sun Apr 08 16:26:00 CST 2018, time=2018-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=273937, encodeId=8f1f2e3937b9, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/12/19/65b621d4a385e517982f632daf4124bb.jpg, createdBy=93302217036, createdName=李香香, createdTime=Sat Dec 30 21:08:26 CST 2017, time=2017-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=273628, encodeId=194e2e362846, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Fri Dec 29 21:48:35 CST 2017, time=2017-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1283587, encodeId=d6f5128358ec2, content=<a href='/topic/show?id=2c00e784416' target=_blank style='color:#2F92EE;'>#细胞因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77844, encryptionId=2c00e784416, topicName=细胞因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0ad8182, createdName=axin009, createdTime=Fri Dec 29 13:26:00 CST 2017, time=2017-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1331988, encodeId=8b13133198850, content=<a href='/topic/show?id=47efe7847a6' target=_blank style='color:#2F92EE;'>#细胞因子图谱#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, 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GetPortalCommentsPageByObjectIdResponse(id=1540504, encodeId=8495154050466, content=<a href='/topic/show?id=fbbce2786cc' target=_blank style='color:#2F92EE;'>#眼病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72786, encryptionId=fbbce2786cc, topicName=眼病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b85c13256921, createdName=pps20023, createdTime=Fri Dec 29 13:26:00 CST 2017, time=2017-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=273078, encodeId=aa712e307872, content=新加坡国家眼科中心的YangM近日在Endocrine发表了一项新的工作.他们从患格雷夫斯眼眶病(GO)患者的泪液中分离特异活性的细胞因子.并对其他感兴趣的细胞因子进行观察., beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Wed Dec 27 23:33:16 CST 2017, time=2017-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=273064, encodeId=520a2e30649f, content=谢谢.学习受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Wed Dec 27 22:53:53 CST 2017, time=2017-12-27, status=1, ipAttribution=)]
    2017-12-29 smartxiuxiu

    有用

    0

  5. 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createdBy=18741984753, createdName=smartxiuxiu, createdTime=Fri Dec 29 21:48:35 CST 2017, time=2017-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1283587, encodeId=d6f5128358ec2, content=<a href='/topic/show?id=2c00e784416' target=_blank style='color:#2F92EE;'>#细胞因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77844, encryptionId=2c00e784416, topicName=细胞因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0ad8182, createdName=axin009, createdTime=Fri Dec 29 13:26:00 CST 2017, time=2017-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1331988, encodeId=8b13133198850, content=<a href='/topic/show?id=47efe7847a6' target=_blank style='color:#2F92EE;'>#细胞因子图谱#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, 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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Wed Dec 27 23:33:16 CST 2017, time=2017-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=273064, encodeId=520a2e30649f, content=谢谢.学习受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Wed Dec 27 22:53:53 CST 2017, time=2017-12-27, status=1, ipAttribution=)]
  6. 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createdBy=18741984753, createdName=smartxiuxiu, createdTime=Fri Dec 29 21:48:35 CST 2017, time=2017-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1283587, encodeId=d6f5128358ec2, content=<a href='/topic/show?id=2c00e784416' target=_blank style='color:#2F92EE;'>#细胞因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77844, encryptionId=2c00e784416, topicName=细胞因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0ad8182, createdName=axin009, createdTime=Fri Dec 29 13:26:00 CST 2017, time=2017-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1331988, encodeId=8b13133198850, content=<a href='/topic/show?id=47efe7847a6' target=_blank style='color:#2F92EE;'>#细胞因子图谱#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, 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  7. 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createdBy=18741984753, createdName=smartxiuxiu, createdTime=Fri Dec 29 21:48:35 CST 2017, time=2017-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1283587, encodeId=d6f5128358ec2, content=<a href='/topic/show?id=2c00e784416' target=_blank style='color:#2F92EE;'>#细胞因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77844, encryptionId=2c00e784416, topicName=细胞因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0ad8182, createdName=axin009, createdTime=Fri Dec 29 13:26:00 CST 2017, time=2017-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1331988, encodeId=8b13133198850, content=<a href='/topic/show?id=47efe7847a6' target=_blank style='color:#2F92EE;'>#细胞因子图谱#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, 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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Wed Dec 27 23:33:16 CST 2017, time=2017-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=273064, encodeId=520a2e30649f, content=谢谢.学习受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Wed Dec 27 22:53:53 CST 2017, time=2017-12-27, status=1, ipAttribution=)]
  8. 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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Wed Dec 27 23:33:16 CST 2017, time=2017-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=273064, encodeId=520a2e30649f, content=谢谢.学习受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Wed Dec 27 22:53:53 CST 2017, time=2017-12-27, status=1, ipAttribution=)]
    2017-12-29 pps20023
  9. 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    2017-12-27 有备才能无患

    新加坡国家眼科中心的YangM近日在Endocrine发表了一项新的工作.他们从患格雷夫斯眼眶病(GO)患者的泪液中分离特异活性的细胞因子.并对其他感兴趣的细胞因子进行观察.

    0

  10. 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    2017-12-27 清风拂面

    谢谢.学习受益匪浅

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