Gut:持续病毒应答对HCV感染肝外表现的风险影响

2017-06-21 海北 MedSci原创

慢性HCV感染和几种肝外表现相关。但是目前,关于持续性病毒反应对于肝外表现风险的影响的数据十分有限。Parag Mahale团队对此进行了回顾性队列研究。

慢性HCV感染和几种肝外表现相关。但是目前,关于持续性病毒反应对于肝外表现风险的影响的数据十分有限。Parag Mahale团队对此进行了回顾性队列研究。他们使用了美国退伍军人事务HCV临床病例登记处的患者数据。接受了干扰素抗病毒治疗的患者被挑选了出来。持续病毒应答指的是,在干扰素治疗结束至少十二周后HCV RNA检测为阴性。 在该研究中,一共分析了160,875名退伍军人的数据,其中31,143名军人接受了干扰素治疗,10,575名军人出现了持续病毒应答。 结果显示,肝外表现风险在干扰素治疗的人群中得到了降低。肝外表现包括混合型冷血球蛋白血症,肾小球肾炎,非霍奇金淋巴瘤,糖尿病等。但是扁平苔藓和冠心病的风险没有降低。同时,在接受治疗的人群中,有持续病毒反应的患者的肝外表现风险也低于没有持续病毒反应的患者。 因此,如果HCV患者接受干扰素治疗,并出现了持续的病毒反应,那么该患者出现肝外表现的风险会降低。此外,早期的干扰素治疗对于降低肾小球性肾炎,非霍奇金淋巴瘤和中风的风险有帮助。原始出处:Parag Mahale et al. The effect of sustained virol

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    2017-06-23 ymljack
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    2017-06-22 stupidox

    学习了,很好。

    0

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    2017-06-21 杨利洪

    学习了,提高了

    0

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